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Facing up to the global challenges of ageing

Author

Listed:
  • Linda Partridge

    (Max Planck Institute for Biology of Ageing
    Evolution and Environment, UCL)

  • Joris Deelen

    (Max Planck Institute for Biology of Ageing
    Leiden University Medical Center)

  • P. Eline Slagboom

    (Max Planck Institute for Biology of Ageing
    Leiden University Medical Center)

Abstract

Longer human lives have led to a global burden of late-life disease. However, some older people experience little ill health, a trait that should be extended to the general population. Interventions into lifestyle, including increased exercise and reduction in food intake and obesity, can help to maintain healthspan. Altered gut microbiota, removal of senescent cells, blood factors obtained from young individuals and drugs can all improve late-life health in animals. Application to humans will require better biomarkers of disease risk and responses to interventions, closer alignment of work in animals and humans, and increased use of electronic health records, biobank resources and cohort studies.

Suggested Citation

  • Linda Partridge & Joris Deelen & P. Eline Slagboom, 2018. "Facing up to the global challenges of ageing," Nature, Nature, vol. 561(7721), pages 45-56, September.
    • Handle: RePEc:nat:nature:v:561:y:2018:i:7721:d:10.1038_s41586-018-0457-8
    DOI: 10.1038/s41586-018-0457-8
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    Cited by:

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    2. Theng Choon Ooi & Devinder Kaur Ajit Singh & Suzana Shahar & Razinah Sharif & Nurul Fatin Malek Rivan & Asheila Meramat & Nor Fadilah Rajab, 2022. "Higher Lead and Lower Calcium Levels Are Associated with Increased Risk of Mortality in Malaysian Older Population: Findings from the LRGS-TUA Longitudinal Study," IJERPH, MDPI, vol. 19(12), pages 1-12, June.
    3. Tsu-Yi Su & Julia Hauenstein & Ece Somuncular & Özge Dumral & Elory Leonard & Charlotte Gustafsson & Efthymios Tzortzis & Aurora Forlani & Anne-Sofie Johansson & Hong Qian & Robert Månsson & Sidinh Lu, 2024. "Aging is associated with functional and molecular changes in distinct hematopoietic stem cell subsets," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    4. Hualong Chang & Mengxing Yao & Biao Chen & Yongle Qi & Jianli Zhang, 2022. "Effects of Blood Flow Restriction Combined with Low-Intensity Resistance Training on Lower-Limb Muscle Strength and Mass in Post-Middle-Aged Adults: A Systematic Review and Meta-Analysis," IJERPH, MDPI, vol. 19(23), pages 1-15, November.
    5. Audrius Dėdelė & Yevheniia Chebotarova & Ričardas Krikštolaitis & Auksė Miškinytė, 2024. "The Impact of Age, COVID-19 and Physical Activity on Life Satisfaction in the European Union: A Cross-Sectional Analysis," Applied Research in Quality of Life, Springer;International Society for Quality-of-Life Studies, vol. 19(5), pages 2617-2631, October.
    6. F. A. Bogaards & T. Gehrmann & M. Beekman & N. Lakenberg & H. E. D. Suchiman & C. P. G. M. Groot & M. J. T. Reinders & P. E. Slagboom, 2024. "Secondary integrated analysis of multi-tissue transcriptomic responses to a combined lifestyle intervention in older adults from the GOTO nonrandomized trial," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    7. Aleksic, Slavisa & Atanasov, Michael & Agius, Jean Calleja & Camilleri, Kenneth & Čartolovni, Anto & Climent-Pérez, Pau & Colantonio, Sara & Cristina, Stefania & Despotovic, Vladimir & Ekenel, Hazim K, 2022. "State of the Art of Audio- and Video-Based Solutions for AAL," EconStor Research Reports 251553, ZBW - Leibniz Information Centre for Economics.
    8. Claudia Giacomozzi & Luigi Palmieri & Lidia Gargiulo & Cinzia Lo Noce & Laura Iannucci & Anna Di Lonardo & Serena Vannucchi & Graziano Onder & Furio Colivicchi & Simona Giampaoli & Chiara Donfrancesco, 2020. "The Perceived Health Status from Young Adults to Elderly: Results of the MEHM Questionnaire within the CUORE Project Survey 2008–2012," IJERPH, MDPI, vol. 17(17), pages 1-17, August.
    9. Olga Tena-Bernal & Marta Sánchez-Peña & Alba Gómez-Cabello & Carlos Salavera & Pablo Usán & Estela Calatayud, 2021. "Cognitive and Functional Differences in Aging with and without Intellectual Disabilities: Observational Study," Sustainability, MDPI, vol. 13(19), pages 1-14, September.
    10. Eleni-Marina Ashikali & Catherine Ludwig & Laura Mastromauro & Samuel Périvier & Aude Tholomier & Irina Ionita & Christophe Graf & Catherine Busnel, 2023. "Intrinsic Capacities, Functional Ability, Physiological Systems, and Caregiver Support: A Targeted Synthesis of Effective Interventions and International Recommendations for Older Adults," IJERPH, MDPI, vol. 20(5), pages 1-26, March.
    11. Adrián Hernández-Vicente & Jorge Marín-Puyalto & Esther Pueyo & Germán Vicente-Rodríguez & Nuria Garatachea, 2022. "Physical Activity in Centenarians beyond Cut-Point-Based Accelerometer Metrics," IJERPH, MDPI, vol. 19(18), pages 1-13, September.
    12. Nor Hana Ahmad Bahuri & Hussein Rizal & Mas Ayu Said & Phyo Kyaw Myint & Tin Tin Su, 2022. "Active Ageing Awareness and Quality of Life among Pre-Elder Malaysian Public Employees," IJERPH, MDPI, vol. 19(15), pages 1-19, July.
    13. Manzoor Ahmad Malik & S. P. Singh & Jyoti Jyoti & Falguni Pattanaik, 2022. "Work stress, health and wellbeing: evidence from the older adults labor market in India," Palgrave Communications, Palgrave Macmillan, vol. 9(1), pages 1-8, December.
    14. Grant Stafford & Noemí Villén & Albert Roso-Llorach & Amelia Troncoso-Mariño & Mònica Monteagudo & Concepción Violán, 2021. "Combined Multimorbidity and Polypharmacy Patterns in the Elderly: A Cross-Sectional Study in Primary Health Care," IJERPH, MDPI, vol. 18(17), pages 1-22, September.
    15. Jorge Lindo & Patrícia Coelho & Catarina Gavinhos & Manuel Martins & Joana Liberal & António Jorge Ferreira & Teresa Gonçalves & Francisco Rodrigues, 2024. "Health Status and COVID-19 Epidemiology in an Inland Region of Portugal: A Retrospective Study," IJERPH, MDPI, vol. 21(8), pages 1-14, August.
    16. Clesyane Alves Figueiredo & Daniella Pires Nunes & Suzimar de Fátima Benato Fusco & Maria Giovana Borges Saidel, 2023. "Perspectives of Brazilian Primary Care Nurses on Mental Health Care for Hypertensive Older Adults: A Qualitative Study," IJERPH, MDPI, vol. 20(12), pages 1-11, June.
    17. Young-Myoung Lim & Kang-Hyun Park & Ji-Hyuk Park, 2023. "Development of Lifestyle Evaluation Tools Based on the Values of the Elderly: A Delphi Study," SAGE Open, , vol. 13(3), pages 21582440231, September.
    18. Wenru Shang & Liping Guo & Yujia Liu & Yanfei Li & Qian Wei & Ke Guo & Minyan Yang & Lili Wei & Zheng Xu & Junqiang Niu & Xiuxia Li & Kehu Yang, 2023. "PROTOCOL: Non‐pharmacological interventions for older people with a diagnosis of depression: An evidence and gap map," Campbell Systematic Reviews, John Wiley & Sons, vol. 19(4), December.

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