IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v19y2022i12p6955-d832915.html
   My bibliography  Save this article

Higher Lead and Lower Calcium Levels Are Associated with Increased Risk of Mortality in Malaysian Older Population: Findings from the LRGS-TUA Longitudinal Study

Author

Listed:
  • Theng Choon Ooi

    (Centre for Healthy Ageing and Wellness, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300, Malaysia)

  • Devinder Kaur Ajit Singh

    (Centre for Healthy Ageing and Wellness, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300, Malaysia)

  • Suzana Shahar

    (Centre for Healthy Ageing and Wellness, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300, Malaysia)

  • Razinah Sharif

    (Centre for Healthy Ageing and Wellness, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300, Malaysia)

  • Nurul Fatin Malek Rivan

    (Centre for Healthy Ageing and Wellness, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300, Malaysia)

  • Asheila Meramat

    (Faculty of Health Sciences, Gong Badak Campus, Universiti Sultan Zainal Abidin, Kuala Nerus 21300, Malaysia)

  • Nor Fadilah Rajab

    (Centre for Healthy Ageing and Wellness, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300, Malaysia)

Abstract

The main objective of this study is to determine the association of various trace elements’ status with the 5-year mortality rate among community-dwelling older adults in Malaysia. This study was part of the Long-term Research Grant Scheme—Towards Useful Ageing (LRGS-TUA). The participants were followed up for five years, and their mortality status was identified through the Mortality Data Matching Service provided by the National Registration Department, Malaysia. Of the 303 participants included in this study, 34 (11.2%) participants had died within five years after baseline data collection. As compared to the survivors, participants who died earlier were more likely ( p < 0.05) to be men, smokers, have a lower intake of total dietary fiber and molybdenum, higher intake of manganese, lower zinc levels in toenail samples, lower calcium and higher lead levels in hair samples during baseline. Following the multivariate Cox proportional hazard analysis, lower total dietary fiber intake (HR: 0.681; 0.532–0.871), lower calcium (HR: 0.999; 95% CI: 0.999–1.000) and higher lead (HR: 1.309; 95% CI: 1.061–1.616) levels in hair samples appeared as the predictors of mortality. In conclusion, higher lead and lower calcium levels are associated with higher risk of mortality among community-dwelling older adults in Malaysia. Our current findings provide a better understanding of how the trace elements’ status may affect older populations’ well-being and mortality rate.

Suggested Citation

  • Theng Choon Ooi & Devinder Kaur Ajit Singh & Suzana Shahar & Razinah Sharif & Nurul Fatin Malek Rivan & Asheila Meramat & Nor Fadilah Rajab, 2022. "Higher Lead and Lower Calcium Levels Are Associated with Increased Risk of Mortality in Malaysian Older Population: Findings from the LRGS-TUA Longitudinal Study," IJERPH, MDPI, vol. 19(12), pages 1-12, June.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:12:p:6955-:d:832915
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/19/12/6955/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/19/12/6955/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Garam Byun & Sera Kim & Soo-Yeon Kim & Dahyun Park & Min-Jeong Shin & Hannah Oh & Jong-Tae Lee, 2020. "Blood Lead Concentrations and Mortality in Korean Adults: the Korea National Health and Nutrition Examination Survey with Mortality Follow-Up," IJERPH, MDPI, vol. 17(18), pages 1-12, September.
    2. Anders Ledberg, 2020. "Exponential increase in mortality with age is a generic property of a simple model system of damage accumulation and death," PLOS ONE, Public Library of Science, vol. 15(6), pages 1-17, June.
    3. Linda Partridge & Joris Deelen & P. Eline Slagboom, 2018. "Facing up to the global challenges of ageing," Nature, Nature, vol. 561(7721), pages 45-56, September.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Claudia Giacomozzi & Luigi Palmieri & Lidia Gargiulo & Cinzia Lo Noce & Laura Iannucci & Anna Di Lonardo & Serena Vannucchi & Graziano Onder & Furio Colivicchi & Simona Giampaoli & Chiara Donfrancesco, 2020. "The Perceived Health Status from Young Adults to Elderly: Results of the MEHM Questionnaire within the CUORE Project Survey 2008–2012," IJERPH, MDPI, vol. 17(17), pages 1-17, August.
    2. Adrián Hernández-Vicente & Jorge Marín-Puyalto & Esther Pueyo & Germán Vicente-Rodríguez & Nuria Garatachea, 2022. "Physical Activity in Centenarians beyond Cut-Point-Based Accelerometer Metrics," IJERPH, MDPI, vol. 19(18), pages 1-13, September.
    3. Nor Hana Ahmad Bahuri & Hussein Rizal & Mas Ayu Said & Phyo Kyaw Myint & Tin Tin Su, 2022. "Active Ageing Awareness and Quality of Life among Pre-Elder Malaysian Public Employees," IJERPH, MDPI, vol. 19(15), pages 1-19, July.
    4. Young-Myoung Lim & Kang-Hyun Park & Ji-Hyuk Park, 2023. "Development of Lifestyle Evaluation Tools Based on the Values of the Elderly: A Delphi Study," SAGE Open, , vol. 13(3), pages 21582440231, September.
    5. Hualong Chang & Mengxing Yao & Biao Chen & Yongle Qi & Jianli Zhang, 2022. "Effects of Blood Flow Restriction Combined with Low-Intensity Resistance Training on Lower-Limb Muscle Strength and Mass in Post-Middle-Aged Adults: A Systematic Review and Meta-Analysis," IJERPH, MDPI, vol. 19(23), pages 1-15, November.
    6. Aleksic, Slavisa & Atanasov, Michael & Agius, Jean Calleja & Camilleri, Kenneth & Čartolovni, Anto & Climent-Pérez, Pau & Colantonio, Sara & Cristina, Stefania & Despotovic, Vladimir & Ekenel, Hazim K, 2022. "State of the Art of Audio- and Video-Based Solutions for AAL," EconStor Research Reports 251553, ZBW - Leibniz Information Centre for Economics.
    7. Sara Chimento-Díaz & Pablo Sánchez-García & Cristina Franco-Antonio & Esperanza Santano-Mogena & Isabel Espino-Tato & Sergio Cordovilla-Guardia, 2022. "Factors Associated with the Acceptance of New Technologies for Ageing in Place by People over 64 Years of Age," IJERPH, MDPI, vol. 19(5), pages 1-18, March.
    8. Olga Tena-Bernal & Marta Sánchez-Peña & Alba Gómez-Cabello & Carlos Salavera & Pablo Usán & Estela Calatayud, 2021. "Cognitive and Functional Differences in Aging with and without Intellectual Disabilities: Observational Study," Sustainability, MDPI, vol. 13(19), pages 1-14, September.
    9. Eleni-Marina Ashikali & Catherine Ludwig & Laura Mastromauro & Samuel Périvier & Aude Tholomier & Irina Ionita & Christophe Graf & Catherine Busnel, 2023. "Intrinsic Capacities, Functional Ability, Physiological Systems, and Caregiver Support: A Targeted Synthesis of Effective Interventions and International Recommendations for Older Adults," IJERPH, MDPI, vol. 20(5), pages 1-26, March.
    10. Clesyane Alves Figueiredo & Daniella Pires Nunes & Suzimar de Fátima Benato Fusco & Maria Giovana Borges Saidel, 2023. "Perspectives of Brazilian Primary Care Nurses on Mental Health Care for Hypertensive Older Adults: A Qualitative Study," IJERPH, MDPI, vol. 20(12), pages 1-11, June.
    11. Lok Ming Tam & Kristin Hocker & Tamala David & Edith Marie Williams, 2024. "The Influence of Social Dynamics on Biological Aging and the Health of Historically Marginalized Populations: A Biopsychosocial Model for Health Disparities," IJERPH, MDPI, vol. 21(5), pages 1-20, April.
    12. Tsu-Yi Su & Julia Hauenstein & Ece Somuncular & Özge Dumral & Elory Leonard & Charlotte Gustafsson & Efthymios Tzortzis & Aurora Forlani & Anne-Sofie Johansson & Hong Qian & Robert Månsson & Sidinh Lu, 2024. "Aging is associated with functional and molecular changes in distinct hematopoietic stem cell subsets," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    13. F. A. Bogaards & T. Gehrmann & M. Beekman & N. Lakenberg & H. E. D. Suchiman & C. P. G. M. Groot & M. J. T. Reinders & P. E. Slagboom, 2024. "Secondary integrated analysis of multi-tissue transcriptomic responses to a combined lifestyle intervention in older adults from the GOTO nonrandomized trial," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    14. Manzoor Ahmad Malik & S. P. Singh & Jyoti Jyoti & Falguni Pattanaik, 2022. "Work stress, health and wellbeing: evidence from the older adults labor market in India," Palgrave Communications, Palgrave Macmillan, vol. 9(1), pages 1-8, December.
    15. Wenru Shang & Liping Guo & Yujia Liu & Yanfei Li & Qian Wei & Ke Guo & Minyan Yang & Lili Wei & Zheng Xu & Junqiang Niu & Xiuxia Li & Kehu Yang, 2023. "PROTOCOL: Non‐pharmacological interventions for older people with a diagnosis of depression: An evidence and gap map," Campbell Systematic Reviews, John Wiley & Sons, vol. 19(4), December.
    16. Audrius Dėdelė & Yevheniia Chebotarova & Ričardas Krikštolaitis & Auksė Miškinytė, 2024. "The Impact of Age, COVID-19 and Physical Activity on Life Satisfaction in the European Union: A Cross-Sectional Analysis," Applied Research in Quality of Life, Springer;International Society for Quality-of-Life Studies, vol. 19(5), pages 2617-2631, October.
    17. Jorge Lindo & Patrícia Coelho & Catarina Gavinhos & Manuel Martins & Joana Liberal & António Jorge Ferreira & Teresa Gonçalves & Francisco Rodrigues, 2024. "Health Status and COVID-19 Epidemiology in an Inland Region of Portugal: A Retrospective Study," IJERPH, MDPI, vol. 21(8), pages 1-14, August.
    18. Grant Stafford & Noemí Villén & Albert Roso-Llorach & Amelia Troncoso-Mariño & Mònica Monteagudo & Concepción Violán, 2021. "Combined Multimorbidity and Polypharmacy Patterns in the Elderly: A Cross-Sectional Study in Primary Health Care," IJERPH, MDPI, vol. 18(17), pages 1-22, September.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:19:y:2022:i:12:p:6955-:d:832915. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.