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Encoding of danger by parabrachial CGRP neurons

Author

Listed:
  • Carlos A. Campos

    (University of Washington)

  • Anna J. Bowen

    (University of Washington)

  • Carolyn W. Roman

    (University of Washington)

  • Richard D. Palmiter

    (University of Washington)

Abstract

Animals must respond to various threats to survive. Neurons that express calcitonin gene-related peptide in the parabrachial nucleus (CGRPPBN neurons) relay sensory signals that contribute to satiation and pain-induced fear behaviour, but it is unclear how they encode these distinct processes. Here, by recording calcium transients in vivo from individual neurons in mice, we show that most CGRPPBN neurons are activated by noxious cutaneous (shock, heat, itch) and visceral stimuli (lipopolysaccharide). The same neurons are inhibited during feeding, but become activated during satiation, consistent with evidence that CGRPPBN neurons prevent overeating. CGRPPBN neurons are also activated during consumption of novel foods or by an auditory cue that has previously been paired with electrical footshocks. Correspondingly, silencing of CGRPPBN neurons attenuates the expression of food neophobia and conditioned fear responses. Therefore, in addition to transducing primary sensory danger signals, CGRPPBN neurons promote affective-behavioural states that limit harm in response to potential threats.

Suggested Citation

  • Carlos A. Campos & Anna J. Bowen & Carolyn W. Roman & Richard D. Palmiter, 2018. "Encoding of danger by parabrachial CGRP neurons," Nature, Nature, vol. 555(7698), pages 617-622, March.
    • Handle: RePEc:nat:nature:v:555:y:2018:i:7698:d:10.1038_nature25511
    DOI: 10.1038/nature25511
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    Cited by:

    1. Takashi Nagashima & Suguru Tohyama & Kaori Mikami & Masashi Nagase & Mieko Morishima & Atsushi Kasai & Hitoshi Hashimoto & Ayako M. Watabe, 2022. "Parabrachial-to-parasubthalamic nucleus pathway mediates fear-induced suppression of feeding in male mice," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    2. Stefano Nardone & Roberto Luca & Antonino Zito & Nataliya Klymko & Dimitris Nicoloutsopoulos & Oren Amsalem & Cory Brannigan & Jon M. Resch & Christopher L. Jacobs & Deepti Pant & Molly Veregge & Hari, 2024. "A spatially-resolved transcriptional atlas of the murine dorsal pons at single-cell resolution," Nature Communications, Nature, vol. 15(1), pages 1-21, December.
    3. Sekun Park & Anqi Zhu & Feng Cao & Richard D. Palmiter, 2024. "Parabrachial Calca neurons mediate second-order conditioning," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    4. Anna J. Bowen & Y. Waterlily Huang & Jane Y. Chen & Jordan L. Pauli & Carlos A. Campos & Richard D. Palmiter, 2023. "Topographic representation of current and future threats in the mouse nociceptive amygdala," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    5. Satvinder Kaur & Nicole Lynch & Yaniv Sela & Janayna D. Lima & Renner C. Thomas & Sathyajit S. Bandaru & Clifford B. Saper, 2024. "Lateral parabrachial FoxP2 neurons regulate respiratory responses to hypercapnia," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    6. Joseph W. Arthurs & Anna J. Bowen & Richard D. Palmiter & Nathan A. Baertsch, 2023. "Parabrachial tachykinin1-expressing neurons involved in state-dependent breathing control," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

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