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MEK drives BRAF activation through allosteric control of KSR proteins

Author

Listed:
  • Hugo Lavoie

    (Institute for Research in Immunology and Cancer Laboratory of Intracellular Signaling Université de Montréal C.P. 6128, Succursale Centre-Ville Montréal)

  • Malha Sahmi

    (Institute for Research in Immunology and Cancer Laboratory of Intracellular Signaling Université de Montréal C.P. 6128, Succursale Centre-Ville Montréal)

  • Pierre Maisonneuve

    (Lunenfeld-Tanenbaum Research Institute, Sinai Health System)

  • Sara A. Marullo

    (Institute for Research in Immunology and Cancer Laboratory of Intracellular Signaling Université de Montréal C.P. 6128, Succursale Centre-Ville Montréal)

  • Neroshan Thevakumaran

    (Lunenfeld-Tanenbaum Research Institute, Sinai Health System
    University of Toronto)

  • Ting Jin

    (Institute for Research in Immunology and Cancer Laboratory of Intracellular Signaling Université de Montréal C.P. 6128, Succursale Centre-Ville Montréal)

  • Igor Kurinov

    (NE-CAT APS, Building 436E, Argonne National Laboratory)

  • Frank Sicheri

    (Lunenfeld-Tanenbaum Research Institute, Sinai Health System
    University of Toronto
    University of Toronto)

  • Marc Therrien

    (Institute for Research in Immunology and Cancer Laboratory of Intracellular Signaling Université de Montréal C.P. 6128, Succursale Centre-Ville Montréal
    Université de Montréal)

Abstract

KSR–MEK complexes allosterically activate BRAF through the action of N-terminal regulatory region and kinase domain contacts, thus challenging the accepted role of KSR as a scaffold for MEK recruitment to RAF.

Suggested Citation

  • Hugo Lavoie & Malha Sahmi & Pierre Maisonneuve & Sara A. Marullo & Neroshan Thevakumaran & Ting Jin & Igor Kurinov & Frank Sicheri & Marc Therrien, 2018. "MEK drives BRAF activation through allosteric control of KSR proteins," Nature, Nature, vol. 554(7693), pages 549-553, February.
    • Handle: RePEc:nat:nature:v:554:y:2018:i:7693:d:10.1038_nature25478
    DOI: 10.1038/nature25478
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    Cited by:

    1. Aline Chessel & Noémie Crozé & Maria Dolores Molina & Laura Taberner & Philippe Dru & Luc Martin & Thierry Lepage, 2023. "RAS-independent ERK activation by constitutively active KSR3 in non-chordate metazoa," Nature Communications, Nature, vol. 14(1), pages 1-26, December.
    2. Eunyoung Park & Shaun Rawson & Anna Schmoker & Byeong-Won Kim & Sehee Oh & Kangkang Song & Hyesung Jeon & Michael J. Eck, 2023. "Cryo-EM structure of a RAS/RAF recruitment complex," Nature Communications, Nature, vol. 14(1), pages 1-11, December.

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