IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v554y2018i7690d10.1038_nature25455.html
   My bibliography  Save this article

Hierarchically related lineage-restricted fates of multipotent haematopoietic stem cells

Author

Listed:
  • Joana Carrelha

    (Haematopoietic Stem Cell Laboratory, MRC Weatherall Institute of Molecular Medicine, University of Oxford
    MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford)

  • Yiran Meng

    (Haematopoietic Stem Cell Laboratory, MRC Weatherall Institute of Molecular Medicine, University of Oxford
    MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford)

  • Laura M. Kettyle

    (Wallenberg Institute for Regenerative Medicine, Karolinska Institutet
    Karolinska Institutet, Center for Hematology and Regenerative Medicine, Karolinska Institutet)

  • Tiago C. Luis

    (Haematopoietic Stem Cell Laboratory, MRC Weatherall Institute of Molecular Medicine, University of Oxford
    MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford)

  • Ruggiero Norfo

    (Haematopoietic Stem Cell Laboratory, MRC Weatherall Institute of Molecular Medicine, University of Oxford
    MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford)

  • Verónica Alcolea

    (Haematopoietic Stem Cell Laboratory, MRC Weatherall Institute of Molecular Medicine, University of Oxford
    MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford)

  • Hanane Boukarabila

    (Haematopoietic Stem Cell Laboratory, MRC Weatherall Institute of Molecular Medicine, University of Oxford
    MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford
    Cincinnati Children's Hospital Medical Center and University of Cincinnati)

  • Francesca Grasso

    (Karolinska Institutet, Center for Hematology and Regenerative Medicine, Karolinska Institutet
    Karolinska University Hospital)

  • Adriana Gambardella

    (MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford)

  • Amit Grover

    (MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford)

  • Kari Högstrand

    (Wallenberg Institute for Regenerative Medicine, Karolinska Institutet
    Karolinska Institutet, Center for Hematology and Regenerative Medicine, Karolinska Institutet)

  • Allegra M. Lord

    (Wallenberg Institute for Regenerative Medicine, Karolinska Institutet
    Karolinska Institutet, Center for Hematology and Regenerative Medicine, Karolinska Institutet)

  • Alejandra Sanjuan-Pla

    (MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford
    Instituto de Investigación Sanitaria La Fe)

  • Petter S. Woll

    (Karolinska Institutet, Center for Hematology and Regenerative Medicine, Karolinska Institutet
    Karolinska University Hospital)

  • Claus Nerlov

    (MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford)

  • Sten Eirik W. Jacobsen

    (Haematopoietic Stem Cell Laboratory, MRC Weatherall Institute of Molecular Medicine, University of Oxford
    MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford
    Wallenberg Institute for Regenerative Medicine, Karolinska Institutet
    Karolinska Institutet, Center for Hematology and Regenerative Medicine, Karolinska Institutet)

Abstract

Analysis of transplantation of single haematopoietic stem cells in mice defines stable lineage-restricted fates in long-term self-renewing multipotent stem cells, including a class of multipotent stem cells that exclusively replenishes the megakaryocyte/platelet lineage.

Suggested Citation

  • Joana Carrelha & Yiran Meng & Laura M. Kettyle & Tiago C. Luis & Ruggiero Norfo & Verónica Alcolea & Hanane Boukarabila & Francesca Grasso & Adriana Gambardella & Amit Grover & Kari Högstrand & Allegr, 2018. "Hierarchically related lineage-restricted fates of multipotent haematopoietic stem cells," Nature, Nature, vol. 554(7690), pages 106-111, February.
    • Handle: RePEc:nat:nature:v:554:y:2018:i:7690:d:10.1038_nature25455
    DOI: 10.1038/nature25455
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature25455
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature25455?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Yinghui Li & Mei He & Wenshan Zhang & Wei Liu & Hui Xu & Ming Yang & Hexiao Zhang & Haiwei Liang & Wenjing Li & Zhaozhao Wu & Weichao Fu & Shiqi Xu & Xiaolei Liu & Sibin Fan & Liwei Zhou & Chaoqun Wan, 2023. "Expansion of human megakaryocyte-biased hematopoietic stem cells by biomimetic Microniche," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    2. Mina N. F. Morcos & Congxin Li & Clara M. Munz & Alessandro Greco & Nicole Dressel & Susanne Reinhardt & Katrin Sameith & Andreas Dahl & Nils B. Becker & Axel Roers & Thomas Höfer & Alexander Gerbaule, 2022. "Fate mapping of hematopoietic stem cells reveals two pathways of native thrombopoiesis," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    3. Reuben Franklin & Yiming Guo & Shiyang He & Meijuan Chen & Fei Ji & Xinyue Zhou & David Frankhouser & Brian T. Do & Carmen Chiem & Mihyun Jang & M. Andres Blanco & Matthew G. Vander Heiden & Russell C, 2022. "Regulation of chromatin accessibility by the histone chaperone CAF-1 sustains lineage fidelity," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    4. Taichi Nakatani & Tatsuki Sugiyama & Yoshiki Omatsu & Hitomi Watanabe & Gen Kondoh & Takashi Nagasawa, 2023. "Ebf3+ niche-derived CXCL12 is required for the localization and maintenance of hematopoietic stem cells," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    5. Brandon Hadland & Barbara Varnum-Finney & Stacey Dozono & Tessa Dignum & Cynthia Nourigat-McKay & Adam M. Heck & Takashi Ishida & Dana L. Jackson & Tomer Itkin & Jason M. Butler & Shahin Rafii & Cole , 2022. "Engineering a niche supporting hematopoietic stem cell development using integrated single-cell transcriptomics," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    6. Tiago C. Luis & Nikolaos Barkas & Joana Carrelha & Alice Giustacchini & Stefania Mazzi & Ruggiero Norfo & Bishan Wu & Affaf Aliouat & Jose A. Guerrero & Alba Rodriguez-Meira & Tiphaine Bouriez-Jones &, 2023. "Perivascular niche cells sense thrombocytopenia and activate hematopoietic stem cells in an IL-1 dependent manner," Nature Communications, Nature, vol. 14(1), pages 1-18, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:554:y:2018:i:7690:d:10.1038_nature25455. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.