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The biology and management of non-small cell lung cancer

Author

Listed:
  • Roy S. Herbst

    (Yale Cancer Center, Yale School of Medicine)

  • Daniel Morgensztern

    (Washington University School of Medicine)

  • Chris Boshoff

    (Yale Cancer Center, Yale School of Medicine
    Pfizer, Inc)

Abstract

Important advancements in the treatment of non-small cell lung cancer (NSCLC) have been achieved over the past two decades, increasing our understanding of the disease biology and mechanisms of tumour progression, and advancing early detection and multimodal care. The use of small molecule tyrosine kinase inhibitors and immunotherapy has led to unprecedented survival benefits in selected patients. However, the overall cure and survival rates for NSCLC remain low, particularly in metastatic disease. Therefore, continued research into new drugs and combination therapies is required to expand the clinical benefit to a broader patient population and to improve outcomes in NSCLC.

Suggested Citation

  • Roy S. Herbst & Daniel Morgensztern & Chris Boshoff, 2018. "The biology and management of non-small cell lung cancer," Nature, Nature, vol. 553(7689), pages 446-454, January.
    • Handle: RePEc:nat:nature:v:553:y:2018:i:7689:d:10.1038_nature25183
    DOI: 10.1038/nature25183
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    Citations

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    Cited by:

    1. Xiang Ge Luo & Jack Kuipers & Niko Beerenwinkel, 2023. "Joint inference of exclusivity patterns and recurrent trajectories from tumor mutation trees," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    2. Michael J. P. Crowley & Bhavneet Bhinder & Geoffrey J. Markowitz & Mitchell Martin & Akanksha Verma & Tito A. Sandoval & Chang-Suk Chae & Shira Yomtoubian & Yang Hu & Sahil Chopra & Diamile A. Tavarez, 2023. "Tumor-intrinsic IRE1α signaling controls protective immunity in lung cancer," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    3. Wei Jiang & Qitao Yu, 2019. "LKB1, a Key Driver Gene of Human Lung Squamous Cell Carcinoma," Biomedical Journal of Scientific & Technical Research, Biomedical Research Network+, LLC, vol. 19(3), pages 14335-14336, July.
    4. Meng Nie & Ke Yao & Xinsheng Zhu & Na Chen & Nan Xiao & Yi Wang & Bo Peng & LiAng Yao & Peng Li & Peng Zhang & Zeping Hu, 2021. "Evolutionary metabolic landscape from preneoplasia to invasive lung adenocarcinoma," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    5. Chen Ni & Xiaohan Lou & Xiaohan Yao & Linlin Wang & Jiajia Wan & Xixi Duan & Jialu Liang & Kaili Zhang & Yuanyuan Yang & Li Zhang & Chanjun Sun & Zhenzhen Li & Ming Wang & Linyu Zhu & Dekang Lv & Zhih, 2022. "ZIP1+ fibroblasts protect lung cancer against chemotherapy via connexin-43 mediated intercellular Zn2+ transfer," Nature Communications, Nature, vol. 13(1), pages 1-20, December.
    6. Xiaobo Yang & Zhilong Mi & Qingcai He & Binghui Guo & Zhiming Zheng, 2023. "Identification of Vital Genes for NSCLC Integrating Mutual Information and Synergy," Mathematics, MDPI, vol. 11(6), pages 1-15, March.
    7. Yu-Yang Bi & Qiu Chen & Ming-Yuan Yang & Lei Xing & Hu-Lin Jiang, 2024. "Nanoparticles targeting mutant p53 overcome chemoresistance and tumor recurrence in non-small cell lung cancer," Nature Communications, Nature, vol. 15(1), pages 1-18, December.

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