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Selective silencing of euchromatic L1s revealed by genome-wide screens for L1 regulators

Author

Listed:
  • Nian Liu

    (Stanford School of Medicine, Stanford University)

  • Cameron H. Lee

    (Stanford School of Medicine, Stanford University)

  • Tomek Swigut

    (Stanford School of Medicine, Stanford University)

  • Edward Grow

    (Stanford School of Medicine, Stanford University
    Huntsman Cancer Institute, University of Utah)

  • Bo Gu

    (Stanford School of Medicine, Stanford University)

  • Michael C. Bassik

    (Stanford School of Medicine, Stanford University
    Stanford University Chemistry, Engineering, and Medicine for Human Health (ChEM-H), Stanford School of Medicine, Stanford University)

  • Joanna Wysocka

    (Stanford School of Medicine, Stanford University
    Institute of Stem Cell Biology and Regenerative Medicine, Stanford School of Medicine, Stanford University
    Stanford School of Medicine, Stanford University
    Howard Hughes Medical Institute, Stanford School of Medicine, Stanford University)

Abstract

The retrotransposition of L1 is controlled by functionally diverse genes at the transcriptional or post-transcriptional levels, and its silencing can lead to the downregulation of host gene expression.

Suggested Citation

  • Nian Liu & Cameron H. Lee & Tomek Swigut & Edward Grow & Bo Gu & Michael C. Bassik & Joanna Wysocka, 2018. "Selective silencing of euchromatic L1s revealed by genome-wide screens for L1 regulators," Nature, Nature, vol. 553(7687), pages 228-232, January.
    • Handle: RePEc:nat:nature:v:553:y:2018:i:7687:d:10.1038_nature25179
    DOI: 10.1038/nature25179
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    Cited by:

    1. Zena D. Jensvold & Julia R. Flood & Anna E. Christenson & Peter W. Lewis, 2024. "Interplay between Two Paralogous Human Silencing Hub (HuSH) Complexes in Regulating LINE-1 Element Silencing," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    2. Ninoslav Pandiloski & Vivien Horváth & Ofelia Karlsson & Symela Koutounidou & Fereshteh Dorazehi & Georgia Christoforidou & Jon Matas-Fuentes & Patricia Gerdes & Raquel Garza & Marie E. Jönsson & Anit, 2024. "DNA methylation governs the sensitivity of repeats to restriction by the HUSH-MORC2 corepressor," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    3. Maya Ron & Igor Ulitsky, 2022. "Context-specific effects of sequence elements on subcellular localization of linear and circular RNAs," Nature Communications, Nature, vol. 13(1), pages 1-13, December.

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