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A metabolic function of FGFR3-TACC3 gene fusions in cancer

Author

Listed:
  • Véronique Frattini

    (Institute for Cancer Genetics, Columbia University Medical Center)

  • Stefano M. Pagnotta

    (Institute for Cancer Genetics, Columbia University Medical Center
    Universita’ degli Studi del Sannio)

  • Tala

    (Institute for Cancer Genetics, Columbia University Medical Center)

  • Jerry J. Fan

    (The Arthur and Sonia Labatt Brain Tumour Research Centre, Program in Developmental and Stem Cell Biology, The Hospital for Sick Children
    University of Toronto, Toronto)

  • Marco V. Russo

    (Institute for Cancer Genetics, Columbia University Medical Center)

  • Sang Bae Lee

    (Institute for Cancer Genetics, Columbia University Medical Center)

  • Luciano Garofano

    (Institute for Cancer Genetics, Columbia University Medical Center
    Universita’ degli Studi del Sannio
    BIOGEM Istituto di Ricerche Genetiche ‘G. Salvatore’, Campo Reale)

  • Jing Zhang

    (Institute for Cancer Genetics, Columbia University Medical Center)

  • Peiguo Shi

    (Institute for Cancer Genetics, Columbia University Medical Center)

  • Genevieve Lewis

    (Institute for Cancer Genetics, Columbia University Medical Center)

  • Heloise Sanson

    (Institute for Cancer Genetics, Columbia University Medical Center)

  • Vanessa Frederick

    (Institute for Cancer Genetics, Columbia University Medical Center)

  • Angelica M. Castano

    (Institute for Cancer Genetics, Columbia University Medical Center)

  • Luigi Cerulo

    (Universita’ degli Studi del Sannio
    BIOGEM Istituto di Ricerche Genetiche ‘G. Salvatore’, Campo Reale)

  • Delphine C. M. Rolland

    (Perelman School of Medicine at University of Pennsylvania)

  • Raghvendra Mall

    (Qatar Computing Research Institute (QCRI), Hamad Bin Khalifa University)

  • Karima Mokhtari

    (Sorbonne Universités UPMC Univ Paris 06, UMR S 1127, Inserm U 1127, CNRS UMR 7225, ICM
    AP-HP, Groupe Hospitalier Pitié Salpêtrière, Laboratoire de Neuropathologie R Escourolle
    Onconeurotek, AP-HP)

  • Kojo S. J. Elenitoba-Johnson

    (Perelman School of Medicine at University of Pennsylvania)

  • Marc Sanson

    (Sorbonne Universités UPMC Univ Paris 06, UMR S 1127, Inserm U 1127, CNRS UMR 7225, ICM
    Onconeurotek, AP-HP
    AP-HP, Hôpital de la Pitié-Salpêtrière)

  • Xi Huang

    (The Arthur and Sonia Labatt Brain Tumour Research Centre, Program in Developmental and Stem Cell Biology, The Hospital for Sick Children
    University of Toronto, Toronto)

  • Michele Ceccarelli

    (Universita’ degli Studi del Sannio
    BIOGEM Istituto di Ricerche Genetiche ‘G. Salvatore’, Campo Reale)

  • Anna Lasorella

    (Institute for Cancer Genetics, Columbia University Medical Center
    Columbia University Medical Center
    Columbia University Medical Center)

  • Antonio Iavarone

    (Institute for Cancer Genetics, Columbia University Medical Center
    Columbia University Medical Center
    Columbia University Medical Center)

Abstract

Oncogenic FGFR3–TACC3 gene fusions signal through phosphorylated PIN4 to trigger biogenesis of peroxisomes and synthesis of new proteins, enabling mitochondrial respiration and tumour growth.

Suggested Citation

  • Véronique Frattini & Stefano M. Pagnotta & Tala & Jerry J. Fan & Marco V. Russo & Sang Bae Lee & Luciano Garofano & Jing Zhang & Peiguo Shi & Genevieve Lewis & Heloise Sanson & Vanessa Frederick & Ang, 2018. "A metabolic function of FGFR3-TACC3 gene fusions in cancer," Nature, Nature, vol. 553(7687), pages 222-227, January.
    • Handle: RePEc:nat:nature:v:553:y:2018:i:7687:d:10.1038_nature25171
    DOI: 10.1038/nature25171
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    Citations

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    Cited by:

    1. Teresa Maria Rosaria Noviello & Anna Maria Giacomo & Francesca Pia Caruso & Alessia Covre & Roberta Mortarini & Giovanni Scala & Maria Claudia Costa & Sandra Coral & Wolf H. Fridman & Catherine Sautès, 2023. "Guadecitabine plus ipilimumab in unresectable melanoma: five-year follow-up and integrated multi-omic analysis in the phase 1b NIBIT-M4 trial," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    2. Sang Bae Lee & Luciano Garofano & Aram Ko & Fulvio D’Angelo & Brulinda Frangaj & Danika Sommer & Qiwen Gan & KyeongJin Kim & Timothy Cardozo & Antonio Iavarone & Anna Lasorella, 2022. "Regulated interaction of ID2 with the anaphase-promoting complex links progression through mitosis with reactivation of cell-type-specific transcription," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    3. Antonio De Falco & Francesca Caruso & Xiao-Dong Su & Antonio Iavarone & Michele Ceccarelli, 2023. "A variational algorithm to detect the clonal copy number substructure of tumors from scRNA-seq data," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    4. Leland S. Hu & Fulvio D’Angelo & Taylor M. Weiskittel & Francesca P. Caruso & Shannon P. Fortin Ensign & Mylan R. Blomquist & Matthew J. Flick & Lujia Wang & Christopher P. Sereduk & Kevin Meng-Lin & , 2023. "Integrated molecular and multiparametric MRI mapping of high-grade glioma identifies regional biologic signatures," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    5. Yuanli Zhen & Kai Liu & Lei Shi & Simran Shah & Qin Xu & Haley Ellis & Eranga R. Balasooriya & Johannes Kreuzer & Robert Morris & Albert S. Baldwin & Dejan Juric & Wilhelm Haas & Nabeel Bardeesy, 2024. "FGFR inhibition blocks NF-ĸB-dependent glucose metabolism and confers metabolic vulnerabilities in cholangiocarcinoma," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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