IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v553y2018i7686d10.1038_nature25167.html
   My bibliography  Save this article

Senescence-associated reprogramming promotes cancer stemness

Author

Listed:
  • Maja Milanovic

    (Charité – Universitätsmedizin Berlin, Oncology and Tumor Immunology, and Molekulares Krebsforschungszentrum – MKFZ, Virchow Campus)

  • Dorothy N. Y. Fan

    (Charité – Universitätsmedizin Berlin, Oncology and Tumor Immunology, and Molekulares Krebsforschungszentrum – MKFZ, Virchow Campus
    Deutsches Konsortium für Translationale Krebsforschung (German Cancer Consortium)
    German Cancer Research Center (Deutsches Krebsforschungszentrum – DKFZ)
    Deutsches Konsortium für Translationale Krebsforschung (German Cancer Consortium), Partner site Berlin)

  • Dimitri Belenki

    (Charité – Universitätsmedizin Berlin, Oncology and Tumor Immunology, and Molekulares Krebsforschungszentrum – MKFZ, Virchow Campus)

  • J. Henry M. Däbritz

    (Charité – Universitätsmedizin Berlin, Oncology and Tumor Immunology, and Molekulares Krebsforschungszentrum – MKFZ, Virchow Campus)

  • Zhen Zhao

    (Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center)

  • Yong Yu

    (Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association)

  • Jan R. Dörr

    (Charité – Universitätsmedizin Berlin, Oncology and Tumor Immunology, and Molekulares Krebsforschungszentrum – MKFZ, Virchow Campus)

  • Lora Dimitrova

    (Charité – Universitätsmedizin Berlin)

  • Dido Lenze

    (Charité – Universitätsmedizin Berlin)

  • Ines A. Monteiro Barbosa

    (Institute of Molecular Pathology (IMP), Vienna Biocenter)

  • Marco A. Mendoza-Parra

    (Equipe Labellisée Ligue Contre le Cancer, Institut de Génétique et de Biologie Moléculaire et Cellulaire, Centre National de la Recherche Scientifique, UMR7104, Institut National de la Santé et de la Recherche Médicale, U964, Université de Strasbourg)

  • Tamara Kanashova

    (Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association)

  • Marlen Metzner

    (Charité – Universitätsmedizin Berlin, Oncology and Tumor Immunology, and Molekulares Krebsforschungszentrum – MKFZ, Virchow Campus)

  • Katharina Pardon

    (Charité – Universitätsmedizin Berlin, Oncology and Tumor Immunology, and Molekulares Krebsforschungszentrum – MKFZ, Virchow Campus)

  • Maurice Reimann

    (Charité – Universitätsmedizin Berlin, Oncology and Tumor Immunology, and Molekulares Krebsforschungszentrum – MKFZ, Virchow Campus)

  • Andreas Trumpp

    (Deutsches Konsortium für Translationale Krebsforschung (German Cancer Consortium)
    German Cancer Research Center (Deutsches Krebsforschungszentrum – DKFZ)
    Deutsches Konsortium für Translationale Krebsforschung (German Cancer Consortium), Partner site Berlin
    Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH))

  • Bernd Dörken

    (Charité – Universitätsmedizin Berlin, Oncology and Tumor Immunology, and Molekulares Krebsforschungszentrum – MKFZ, Virchow Campus
    Deutsches Konsortium für Translationale Krebsforschung (German Cancer Consortium)
    Deutsches Konsortium für Translationale Krebsforschung (German Cancer Consortium), Partner site Berlin
    Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association)

  • Johannes Zuber

    (Institute of Molecular Pathology (IMP), Vienna Biocenter)

  • Hinrich Gronemeyer

    (Equipe Labellisée Ligue Contre le Cancer, Institut de Génétique et de Biologie Moléculaire et Cellulaire, Centre National de la Recherche Scientifique, UMR7104, Institut National de la Santé et de la Recherche Médicale, U964, Université de Strasbourg)

  • Michael Hummel

    (Deutsches Konsortium für Translationale Krebsforschung (German Cancer Consortium)
    Deutsches Konsortium für Translationale Krebsforschung (German Cancer Consortium), Partner site Berlin
    Charité – Universitätsmedizin Berlin
    Berlin Institute of Health)

  • Gunnar Dittmar

    (Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association
    Luxembourg Institute of Health)

  • Soyoung Lee

    (Charité – Universitätsmedizin Berlin, Oncology and Tumor Immunology, and Molekulares Krebsforschungszentrum – MKFZ, Virchow Campus
    Deutsches Konsortium für Translationale Krebsforschung (German Cancer Consortium)
    Deutsches Konsortium für Translationale Krebsforschung (German Cancer Consortium), Partner site Berlin
    Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association)

  • Clemens A. Schmitt

    (Charité – Universitätsmedizin Berlin, Oncology and Tumor Immunology, and Molekulares Krebsforschungszentrum – MKFZ, Virchow Campus
    Deutsches Konsortium für Translationale Krebsforschung (German Cancer Consortium)
    Deutsches Konsortium für Translationale Krebsforschung (German Cancer Consortium), Partner site Berlin
    Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association)

Abstract

Cellular senescence induced by chemotherapy leads to the acquisition of stemness in cancer cells, which results in enhanced tumour-promoting capacity after forced release or spontaneous escape from the senescent cell-cycle arrest.

Suggested Citation

  • Maja Milanovic & Dorothy N. Y. Fan & Dimitri Belenki & J. Henry M. Däbritz & Zhen Zhao & Yong Yu & Jan R. Dörr & Lora Dimitrova & Dido Lenze & Ines A. Monteiro Barbosa & Marco A. Mendoza-Parra & Tamar, 2018. "Senescence-associated reprogramming promotes cancer stemness," Nature, Nature, vol. 553(7686), pages 96-100, January.
    • Handle: RePEc:nat:nature:v:553:y:2018:i:7686:d:10.1038_nature25167
    DOI: 10.1038/nature25167
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature25167
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature25167?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Laura Solé & Teresa Lobo-Jarne & Daniel Álvarez-Villanueva & Josune Alonso-Marañón & Yolanda Guillén & Marta Guix & Irene Sangrador & Catalina Rozalén & Anna Vert & Antonio Barbachano & Joan Lop & Mar, 2022. "p53 wild-type colorectal cancer cells that express a fetal gene signature are associated with metastasis and poor prognosis," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    2. Matteo Maria Naldini & Gabriele Casirati & Matteo Barcella & Paola Maria Vittoria Rancoita & Andrea Cosentino & Carolina Caserta & Francesca Pavesi & Erika Zonari & Giacomo Desantis & Diego Gilioli & , 2023. "Longitudinal single-cell profiling of chemotherapy response in acute myeloid leukemia," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    3. Humza M. Ashraf & Brianna Fernandez & Sabrina L. Spencer, 2023. "The intensities of canonical senescence biomarkers integrate the duration of cell-cycle withdrawal," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    4. Huiru Bai & Xiaoqin Liu & Meizhen Lin & Yuan Meng & Ruolan Tang & Yajing Guo & Nan Li & Michael F. Clarke & Shang Cai, 2024. "Progressive senescence programs induce intrinsic vulnerability to aging-related female breast cancer," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    5. Cathy Pichol-Thievend & Oceane Anezo & Aafrin M. Pettiwala & Guillaume Bourmeau & Remi Montagne & Anne-Marie Lyne & Pierre-Olivier Guichet & Pauline Deshors & Alberto Ballestín & Benjamin Blanchard & , 2024. "VC-resist glioblastoma cell state: vessel co-option as a key driver of chemoradiation resistance," Nature Communications, Nature, vol. 15(1), pages 1-27, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:553:y:2018:i:7686:d:10.1038_nature25167. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.