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Structure of the complement C5a receptor bound to the extra-helical antagonist NDT9513727

Author

Listed:
  • Nathan Robertson

    (Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City)

  • Mathieu Rappas

    (Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City)

  • Andrew S. Doré

    (Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City)

  • Jason Brown

    (Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City)

  • Giovanni Bottegoni

    (Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City)

  • Markus Koglin

    (Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City)

  • Julie Cansfield

    (Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City)

  • Ali Jazayeri

    (Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City)

  • Robert M. Cooke

    (Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City)

  • Fiona H. Marshall

    (Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City)

Abstract

The crystal structure of the complement receptor C5aR1 bound to a small-molecule antagonist provides insights into this receptor class and how they could be better targeted therapeutically.

Suggested Citation

  • Nathan Robertson & Mathieu Rappas & Andrew S. Doré & Jason Brown & Giovanni Bottegoni & Markus Koglin & Julie Cansfield & Ali Jazayeri & Robert M. Cooke & Fiona H. Marshall, 2018. "Structure of the complement C5a receptor bound to the extra-helical antagonist NDT9513727," Nature, Nature, vol. 553(7686), pages 111-114, January.
    • Handle: RePEc:nat:nature:v:553:y:2018:i:7686:d:10.1038_nature25025
    DOI: 10.1038/nature25025
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    Cited by:

    1. Otavio Cabral-Marques & Gilad Halpert & Lena F. Schimke & Yuri Ostrinski & Aristo Vojdani & Gabriela Crispim Baiocchi & Paula Paccielli Freire & Igor Salerno Filgueiras & Israel Zyskind & Miriam T. La, 2022. "Autoantibodies targeting GPCRs and RAS-related molecules associate with COVID-19 severity," Nature Communications, Nature, vol. 13(1), pages 1-12, December.

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