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Cyclin D–CDK4 kinase destabilizes PD-L1 via cullin 3–SPOP to control cancer immune surveillance

Author

Listed:
  • Jinfang Zhang

    (Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Xia Bu

    (Dana-Farber Cancer Institute, Harvard Medical School)

  • Haizhen Wang

    (Harvard Medical School)

  • Yasheng Zhu

    (Shanghai Changhai Hospital, Second Military Medical University)

  • Yan Geng

    (Harvard Medical School)

  • Naoe Taira Nihira

    (Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Yuyong Tan

    (Beth Israel Deaconess Medical Center, Harvard Medical School
    the Second Xiangya Hospital of Central South University)

  • Yanpeng Ci

    (Beth Israel Deaconess Medical Center, Harvard Medical School
    School of Life Science and Technology, Harbin Institute of Technology)

  • Fei Wu

    (Beth Israel Deaconess Medical Center, Harvard Medical School
    Huashan Hospital, Fudan University)

  • Xiangpeng Dai

    (Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Jianping Guo

    (Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Yu-Han Huang

    (Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Caoqi Fan

    (Harvard Medical School
    Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, School of Life Sciences, Peking University)

  • Shancheng Ren

    (Shanghai Changhai Hospital, Second Military Medical University)

  • Yinghao Sun

    (Shanghai Changhai Hospital, Second Military Medical University)

  • Gordon J. Freeman

    (Dana-Farber Cancer Institute, Harvard Medical School)

  • Piotr Sicinski

    (Harvard Medical School)

  • Wenyi Wei

    (Beth Israel Deaconess Medical Center, Harvard Medical School)

Abstract

Abundance of PD-L1, the ligand of the anti-cancer immunotherapy target PD-1, is negatively regulated by poly-ubiquitination via the cyclin D–CDK4/cullin 3–SPOP axis and PD-1 blockade treatment in mice improved survival when combined with CDK4/6 inhibitors.

Suggested Citation

  • Jinfang Zhang & Xia Bu & Haizhen Wang & Yasheng Zhu & Yan Geng & Naoe Taira Nihira & Yuyong Tan & Yanpeng Ci & Fei Wu & Xiangpeng Dai & Jianping Guo & Yu-Han Huang & Caoqi Fan & Shancheng Ren & Yingha, 2018. "Cyclin D–CDK4 kinase destabilizes PD-L1 via cullin 3–SPOP to control cancer immune surveillance," Nature, Nature, vol. 553(7686), pages 91-95, January.
    • Handle: RePEc:nat:nature:v:553:y:2018:i:7686:d:10.1038_nature25015
    DOI: 10.1038/nature25015
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    Cited by:

    1. Qing Li & Liren Zhang & Wenhua You & Jiali Xu & Jingjing Dai & Dongxu Hua & Ruizhi Zhang & Feifan Yao & Suiqing Zhou & Wei Huang & Yongjiu Dai & Yu Zhang & Tasiken Baheti & Xiaofeng Qian & Liyong Pu &, 2022. "PRDM1/BLIMP1 induces cancer immune evasion by modulating the USP22-SPI1-PD-L1 axis in hepatocellular carcinoma cells," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    2. Zhen Shu & Bhakti Dwivedi & Jeffrey M. Switchenko & David S. Yu & Xingming Deng, 2024. "PD-L1 deglycosylation promotes its nuclear translocation and accelerates DNA double-strand-break repair in cancer," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    3. Chandrani Mukhopadhyay & Chenyi Yang & Limei Xu & Deli Liu & Yu Wang & Dennis Huang & Lesa Dayal Deonarine & Joanna Cyrta & Elai Davicioni & Andrea Sboner & Brian. D. Robinson & Arul M. Chinnaiyan & M, 2021. "G3BP1 inhibits Cul3SPOP to amplify AR signaling and promote prostate cancer," Nature Communications, Nature, vol. 12(1), pages 1-18, December.
    4. Wenjun Xiong & Xueliang Gao & Tiantian Zhang & Baishan Jiang & Ming-Ming Hu & Xia Bu & Yang Gao & Lin-Zhou Zhang & Bo-Lin Xiao & Chuan He & Yishuang Sun & Haiou Li & Jie Shi & Xiangling Xiao & Bolin X, 2022. "USP8 inhibition reshapes an inflamed tumor microenvironment that potentiates the immunotherapy," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    5. Di Wu & Haomin Li & Mingwei Liu & Jun Qin & Yi Sun, 2022. "The Ube2m-Rbx1 neddylation-Cullin-RING-Ligase proteins are essential for the maintenance of Regulatory T cell fitness," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    6. Quanyuan Wan & Leah Tavakoli & Ting-Yu Wang & Andrew J. Tucker & Ruiting Zhou & Qizhi Liu & Shu Feng & Dongwon Choi & Zhiheng He & Michaela U. Gack & Jun Zhao, 2024. "Hijacking of nucleotide biosynthesis and deamidation-mediated glycolysis by an oncogenic herpesvirus," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    7. Wenfeng Ren & Zilong Xu & Yating Chang & Fei Ju & Hongning Wu & Zhiqi Liang & Min Zhao & Naizhen Wang & Yanhua Lin & Chenhang Xu & Shengming Chen & Yipeng Rao & Chaolong Lin & Jianxin Yang & Pingguo L, 2024. "Pharmaceutical targeting of OTUB2 sensitizes tumors to cytotoxic T cells via degradation of PD-L1," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    8. Qiwei Jiang & Xiaomei Zhang & Xiaoming Dai & Shiyao Han & Xueji Wu & Lei Wang & Wenyi Wei & Ning Zhang & Wei Xie & Jianping Guo, 2022. "S6K1-mediated phosphorylation of PDK1 impairs AKT kinase activity and oncogenic functions," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    9. Yue Wang & Dhamotharan Pattarayan & Haozhe Huang & Yueshan Zhao & Sihan Li & Yifei Wang & Min Zhang & Song Li & Da Yang, 2024. "Systematic investigation of chemo-immunotherapy synergism to shift anti-PD-1 resistance in cancer," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    10. Jingjie Yi & Omid Tavana & Huan Li & Donglai Wang & Richard J. Baer & Wei Gu, 2023. "Targeting USP2 regulation of VPRBP-mediated degradation of p53 and PD-L1 for cancer therapy," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    11. Moataz Reda & Worapol Ngamcherdtrakul & Molly A. Nelson & Natnaree Siriwon & Ruijie Wang & Husam Y. Zaidan & Daniel S. Bejan & Sherif Reda & Ngoc Ha Hoang & Noah A. Crumrine & Justin P. C. Rehwaldt & , 2022. "Development of a nanoparticle-based immunotherapy targeting PD-L1 and PLK1 for lung cancer treatment," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    12. Jing Liu & Xia Bu & Chen Chu & Xiaoming Dai & John M. Asara & Piotr Sicinski & Gordon J. Freeman & Wenyi Wei, 2023. "PRMT1 mediated methylation of cGAS suppresses anti-tumor immunity," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

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