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Pluripotent state transitions coordinate morphogenesis in mouse and human embryos

Author

Listed:
  • Marta N. Shahbazi

    (Mammalian Embryo and Stem Cell Group, University of Cambridge, Development and Neuroscience, Downing Street)

  • Antonio Scialdone

    (EMBL-European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus
    Institute of Epigenetics and Stem Cells, Helmholtz Zentrum München)

  • Natalia Skorupska

    (Mammalian Embryo and Stem Cell Group, University of Cambridge, Development and Neuroscience, Downing Street)

  • Antonia Weberling

    (Mammalian Embryo and Stem Cell Group, University of Cambridge, Development and Neuroscience, Downing Street)

  • Gaelle Recher

    (Mammalian Embryo and Stem Cell Group, University of Cambridge, Development and Neuroscience, Downing Street
    IOGS, CNRS & University of Bordeaux, Rue Francois Mitterrand)

  • Meng Zhu

    (Mammalian Embryo and Stem Cell Group, University of Cambridge, Development and Neuroscience, Downing Street)

  • Agnieszka Jedrusik

    (Mammalian Embryo and Stem Cell Group, University of Cambridge, Development and Neuroscience, Downing Street)

  • Liani G. Devito

    (Faculty of Life Sciences and Medicine, King’s College London, Women’s Health Academic Centre, Assisted Conception Unit, Guy’s Hospital, Great Maze Pond)

  • Laila Noli

    (Faculty of Life Sciences and Medicine, King’s College London, Women’s Health Academic Centre, Assisted Conception Unit, Guy’s Hospital, Great Maze Pond)

  • Iain C. Macaulay

    (Wellcome Trust Sanger Institute, Wellcome Genome Campus
    Earlham Institute, Norwich Research Park)

  • Christa Buecker

    (Stanford University School of Medicine, Stanford
    Max F. Perutz Laboratories, Vienna Biocenter (VBC))

  • Yakoub Khalaf

    (Faculty of Life Sciences and Medicine, King’s College London, Women’s Health Academic Centre, Assisted Conception Unit, Guy’s Hospital, Great Maze Pond)

  • Dusko Ilic

    (Faculty of Life Sciences and Medicine, King’s College London, Women’s Health Academic Centre, Assisted Conception Unit, Guy’s Hospital, Great Maze Pond)

  • Thierry Voet

    (Wellcome Trust Sanger Institute, Wellcome Genome Campus
    Laboratory of Reproductive Genomics, KU Leuven)

  • John C. Marioni

    (EMBL-European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus
    Wellcome Trust Sanger Institute, Wellcome Genome Campus
    Cancer Research UK Cambridge Institute, University of Cambridge)

  • Magdalena Zernicka-Goetz

    (Mammalian Embryo and Stem Cell Group, University of Cambridge, Development and Neuroscience, Downing Street)

Abstract

Exit of epiblasts from an unrestricted naive pluripotent state is required for epithelialization and generation of the pro-amniotic cavity in mouse embryos and for amniotic cavity formation in human embryos and human embryonic stem cells.

Suggested Citation

  • Marta N. Shahbazi & Antonio Scialdone & Natalia Skorupska & Antonia Weberling & Gaelle Recher & Meng Zhu & Agnieszka Jedrusik & Liani G. Devito & Laila Noli & Iain C. Macaulay & Christa Buecker & Yako, 2017. "Pluripotent state transitions coordinate morphogenesis in mouse and human embryos," Nature, Nature, vol. 552(7684), pages 239-243, December.
    • Handle: RePEc:nat:nature:v:552:y:2017:i:7684:d:10.1038_nature24675
    DOI: 10.1038/nature24675
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    Citations

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    Cited by:

    1. King Hang Tommy Mau & Donja Karimlou & David Barneda & Vincent Brochard & Christophe Royer & Bryony Leeke & Roshni A. Souza & Mélanie Pailles & Michelle Percharde & Shankar Srinivas & Alice Jouneau & , 2022. "Dynamic enlargement and mobilization of lipid droplets in pluripotent cells coordinate morphogenesis during mouse peri-implantation development," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    2. Céline Labouesse & Bao Xiu Tan & Chibeza C. Agley & Moritz Hofer & Alexander K. Winkel & Giuliano G. Stirparo & Hannah T. Stuart & Christophe M. Verstreken & Carla Mulas & William Mansfield & Paul Ber, 2021. "StemBond hydrogels control the mechanical microenvironment for pluripotent stem cells," Nature Communications, Nature, vol. 12(1), pages 1-17, December.
    3. Woranop Sukparangsi & Elena Morganti & Molly Lowndes & Hélène Mayeur & Melanie Weisser & Fella Hammachi & Hanna Peradziryi & Fabian Roske & Jurriaan Hölzenspies & Alessandra Livigni & Benoit Gilbert G, 2022. "Evolutionary origin of vertebrate OCT4/POU5 functions in supporting pluripotency," Nature Communications, Nature, vol. 13(1), pages 1-21, December.
    4. Anna Malkowska & Christopher Penfold & Sophie Bergmann & Thorsten E. Boroviak, 2022. "A hexa-species transcriptome atlas of mammalian embryogenesis delineates metabolic regulation across three different implantation modes," Nature Communications, Nature, vol. 13(1), pages 1-12, December.

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