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Force loading explains spatial sensing of ligands by cells

Author

Listed:
  • Roger Oria

    (Institute for Bioengineering of Catalonia (IBEC), the Barcelona Institute of Technology (BIST)
    University of Barcelona)

  • Tina Wiegand

    (Max Planck Institute for Medical Research
    Heidelberg University)

  • Jorge Escribano

    (Aragon Institute of Engineering Research (I3A), University of Zaragoza)

  • Alberto Elosegui-Artola

    (Institute for Bioengineering of Catalonia (IBEC), the Barcelona Institute of Technology (BIST))

  • Juan Jose Uriarte

    (University of Barcelona)

  • Cristian Moreno-Pulido

    (Institute for Bioengineering of Catalonia (IBEC), the Barcelona Institute of Technology (BIST))

  • Ilia Platzman

    (Max Planck Institute for Medical Research
    Heidelberg University)

  • Pietro Delcanale

    (Institute for Bioengineering of Catalonia (IBEC), the Barcelona Institute of Technology (BIST))

  • Lorenzo Albertazzi

    (Institute for Bioengineering of Catalonia (IBEC), the Barcelona Institute of Technology (BIST))

  • Daniel Navajas

    (Institute for Bioengineering of Catalonia (IBEC), the Barcelona Institute of Technology (BIST)
    University of Barcelona
    Centro de Investigación Biomédica en Red en Enfermedades Respiratorias, Instituto de Salud Carlos III)

  • Xavier Trepat

    (Institute for Bioengineering of Catalonia (IBEC), the Barcelona Institute of Technology (BIST)
    University of Barcelona
    Institució Catalana de Recerca i Estudis Avançats
    Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina)

  • José Manuel García-Aznar

    (Aragon Institute of Engineering Research (I3A), University of Zaragoza)

  • Elisabetta Ada Cavalcanti-Adam

    (Max Planck Institute for Medical Research
    Heidelberg University)

  • Pere Roca-Cusachs

    (Institute for Bioengineering of Catalonia (IBEC), the Barcelona Institute of Technology (BIST)
    University of Barcelona)

Abstract

The formation of cellular adhesion complexes is important in normal and pathological cell activity, and is determined by the force imposed by the combined effect of the distribution of extracellular matrix molecules and substrate rigidity.

Suggested Citation

  • Roger Oria & Tina Wiegand & Jorge Escribano & Alberto Elosegui-Artola & Juan Jose Uriarte & Cristian Moreno-Pulido & Ilia Platzman & Pietro Delcanale & Lorenzo Albertazzi & Daniel Navajas & Xavier Tre, 2017. "Force loading explains spatial sensing of ligands by cells," Nature, Nature, vol. 552(7684), pages 219-224, December.
    • Handle: RePEc:nat:nature:v:552:y:2017:i:7684:d:10.1038_nature24662
    DOI: 10.1038/nature24662
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    Cited by:

    1. Tianchi Chen & Cecilia H. Fernández-Espartero & Abigail Illand & Ching-Ting Tsai & Yang Yang & Benjamin Klapholz & Pierre Jouchet & Mélanie Fabre & Olivier Rossier & Bianxiao Cui & Sandrine Lévêque-Fo, 2024. "Actin-driven nanotopography promotes stable integrin adhesion formation in developing tissue," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

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