IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v552y2017i7683d10.1038_nature24678.html
   My bibliography  Save this article

Promoter-bound METTL3 maintains myeloid leukaemia by m6A-dependent translation control

Author

Listed:
  • Isaia Barbieri

    (University of Cambridge)

  • Konstantinos Tzelepis

    (Haematological Cancer Genetics, Wellcome Trust Sanger Institute)

  • Luca Pandolfini

    (University of Cambridge)

  • Junwei Shi

    (Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor
    University of Pennsylvania)

  • Gonzalo Millán-Zambrano

    (University of Cambridge)

  • Samuel C. Robson

    (University of Cambridge
    University of Portsmouth)

  • Demetrios Aspris

    (Haematological Cancer Genetics, Wellcome Trust Sanger Institute)

  • Valentina Migliori

    (University of Cambridge)

  • Andrew J. Bannister

    (University of Cambridge)

  • Namshik Han

    (University of Cambridge)

  • Etienne De Braekeleer

    (Haematological Cancer Genetics, Wellcome Trust Sanger Institute)

  • Hannes Ponstingl

    (Haematological Cancer Genetics, Wellcome Trust Sanger Institute)

  • Alan Hendrick

    (Storm Therapeutics Ltd, Moneta Building (B280), Babraham Research Campus)

  • Christopher R. Vakoc

    (Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor)

  • George S. Vassiliou

    (Haematological Cancer Genetics, Wellcome Trust Sanger Institute
    Wellcome Trust–MRC Cambridge Stem Cell Institute, University of Cambridge
    Cambridge University Hospitals NHS Trust)

  • Tony Kouzarides

    (University of Cambridge)

Abstract

The methyltransferase METTL3 promotes the leukaemic state in acute myeloid leukaemia (AML) by catalysing the m6A RNA modification through its recruitment on the transcription start sites of AML-associated genes.

Suggested Citation

  • Isaia Barbieri & Konstantinos Tzelepis & Luca Pandolfini & Junwei Shi & Gonzalo Millán-Zambrano & Samuel C. Robson & Demetrios Aspris & Valentina Migliori & Andrew J. Bannister & Namshik Han & Etienne, 2017. "Promoter-bound METTL3 maintains myeloid leukaemia by m6A-dependent translation control," Nature, Nature, vol. 552(7683), pages 126-131, December.
    • Handle: RePEc:nat:nature:v:552:y:2017:i:7683:d:10.1038_nature24678
    DOI: 10.1038/nature24678
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature24678
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature24678?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Yuanpei Li & Xiaoniu He & Xiao Lu & Zhicheng Gong & Qing Li & Lei Zhang & Ronghui Yang & Chengyi Wu & Jialiang Huang & Jiancheng Ding & Yaohui He & Wen Liu & Ceshi Chen & Bin Cao & Dawang Zhou & Yufen, 2022. "METTL3 acetylation impedes cancer metastasis via fine-tuning its nuclear and cytosolic functions," Nature Communications, Nature, vol. 13(1), pages 1-23, December.
    2. Shujie Chen, & Lu Zhang & Mengjie Li & Ying Zhang & Meng Sun & Lingfang Wang & Jiebo Lin & Yun Cui & Qian Chen & Chenqi Jin & Xiang Li & Boya Wang & Hao Chen & Tianhua Zhou & Liangjing Wang & Chih-Hun, 2022. "Fusobacterium nucleatum reduces METTL3-mediated m6A modification and contributes to colorectal cancer metastasis," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    3. Xin Yang & Robinson Triboulet & Qi Liu & Erdem Sendinc & Richard I. Gregory, 2022. "Exon junction complex shapes the m6A epitranscriptome," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    4. Xinzhi Li & Bingchuan Yuan & Min Lu & Yuqin Wang & Na Ding & Chunhong Liu & Ming Gao & Zhicheng Yao & Shiyan Zhang & Yujun Zhao & Liwei Xie & Zheng Chen, 2021. "The methyltransferase METTL3 negatively regulates nonalcoholic steatohepatitis (NASH) progression," Nature Communications, Nature, vol. 12(1), pages 1-17, December.
    5. Adrien Leger & Paulo P. Amaral & Luca Pandolfini & Charlotte Capitanchik & Federica Capraro & Valentina Miano & Valentina Migliori & Patrick Toolan-Kerr & Theodora Sideri & Anton J. Enright & Konstant, 2021. "RNA modifications detection by comparative Nanopore direct RNA sequencing," Nature Communications, Nature, vol. 12(1), pages 1-17, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:552:y:2017:i:7683:d:10.1038_nature24678. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.