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IL-11 is a crucial determinant of cardiovascular fibrosis

Author

Listed:
  • Sebastian Schafer

    (National Heart Centre Singapore
    Duke–National University of Singapore Medical School)

  • Sivakumar Viswanathan

    (Duke–National University of Singapore Medical School)

  • Anissa A. Widjaja

    (Duke–National University of Singapore Medical School)

  • Wei-Wen Lim

    (National Heart Centre Singapore)

  • Aida Moreno-Moral

    (Duke–National University of Singapore Medical School)

  • Daniel M. DeLaughter

    (Harvard Medical School)

  • Benjamin Ng

    (National Heart Centre Singapore)

  • Giannino Patone

    (Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC))

  • Kingsley Chow

    (National Heart Centre Singapore)

  • Ester Khin

    (Duke–National University of Singapore Medical School)

  • Jessie Tan

    (National Heart Centre Singapore)

  • Sonia P. Chothani

    (Duke–National University of Singapore Medical School)

  • Lei Ye

    (National Heart Centre Singapore)

  • Owen J. L. Rackham

    (Duke–National University of Singapore Medical School)

  • Nicole S. J. Ko

    (Duke–National University of Singapore Medical School)

  • Norliza E. Sahib

    (Duke–National University of Singapore Medical School)

  • Chee Jian Pua

    (National Heart Centre Singapore)

  • Nicole T. G. Zhen

    (National Heart Centre Singapore)

  • Chen Xie

    (National Heart Centre Singapore)

  • Mao Wang

    (Duke–National University of Singapore Medical School)

  • Henrike Maatz

    (Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC))

  • Shiqi Lim

    (National Heart Centre Singapore)

  • Kathrin Saar

    (Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC))

  • Susanne Blachut

    (Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC))

  • Enrico Petretto

    (Duke–National University of Singapore Medical School)

  • Sabine Schmidt

    (Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC))

  • Tracy Putoczki

    (Walter and Eliza Hall Institute of Medical Research
    The University of Melbourne)

  • Nuno Guimarães-Camboa

    (Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego)

  • Hiroko Wakimoto

    (Harvard Medical School)

  • Sebastiaan van Heesch

    (Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC))

  • Kristmundur Sigmundsson

    (Duke–National University of Singapore Medical School)

  • See L. Lim

    (National Heart Centre Singapore)

  • Jia L. Soon

    (National Heart Centre Singapore
    Duke–National University of Singapore Medical School)

  • Victor T. T. Chao

    (National Heart Centre Singapore
    Duke–National University of Singapore Medical School)

  • Yeow L. Chua

    (National Heart Centre Singapore)

  • Teing E. Tan

    (National Heart Centre Singapore)

  • Sylvia M. Evans

    (Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego
    University of California at San Diego
    University of California at San Diego)

  • Yee J. Loh

    (National Heart Centre Singapore
    Kandang Kerbau Women’s and Children’s Hospital)

  • Muhammad H. Jamal

    (National Heart Centre Singapore)

  • Kim K. Ong

    (National Heart Centre Singapore
    Kandang Kerbau Women’s and Children’s Hospital)

  • Kim C. Chua

    (National Heart Centre Singapore)

  • Boon-Hean Ong

    (National Heart Centre Singapore)

  • Mathew J. Chakaramakkil

    (National Heart Centre Singapore)

  • Jonathan G. Seidman

    (Harvard Medical School)

  • Christine E. Seidman

    (Harvard Medical School
    Brigham and Women’s Hospital
    Howard Hughes Medical Institute)

  • Norbert Hubner

    (Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC)
    DZHK (German Centre for Cardiovascular Research)
    Charité-Universitätsmedizin
    Berlin Institute of Health (BIH))

  • Kenny Y. K. Sin

    (National Heart Centre Singapore
    Duke–National University of Singapore Medical School)

  • Stuart A. Cook

    (National Heart Centre Singapore
    Duke–National University of Singapore Medical School
    National Heart and Lung Institute, Imperial College London
    MRC-London Institute of Medical Sciences, Hammersmith Hospital Campus)

Abstract

Fibroblast-specific Il-11 expression causes heart and kidney fibrosis and organ failure, whereas IL-11 inhibition prevents fibroblast activation and organ fibrosis, indicating that IL-11 inhibition is a potential therapeutic strategy to treat fibrotic diseases.

Suggested Citation

  • Sebastian Schafer & Sivakumar Viswanathan & Anissa A. Widjaja & Wei-Wen Lim & Aida Moreno-Moral & Daniel M. DeLaughter & Benjamin Ng & Giannino Patone & Kingsley Chow & Ester Khin & Jessie Tan & Sonia, 2017. "IL-11 is a crucial determinant of cardiovascular fibrosis," Nature, Nature, vol. 552(7683), pages 110-115, December.
    • Handle: RePEc:nat:nature:v:552:y:2017:i:7683:d:10.1038_nature24676
    DOI: 10.1038/nature24676
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    Citations

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    Cited by:

    1. Tao Zhuang & Mei-Hua Chen & Ruo-Xi Wu & Jing Wang & Xi-De Hu & Ting Meng & Ai-Hua Wu & Yan Li & Yong-Feng Yang & Yu Lei & Dong-Hua Hu & Yan-Xiu Li & Li Zhang & Ai-Jun Sun & Wei Lu & Guan-Nan Zhang & J, 2024. "ALKBH5-mediated m6A modification of IL-11 drives macrophage-to-myofibroblast transition and pathological cardiac fibrosis in mice," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    2. Qian-Qian Chen & Kang Liu & Ning Shi & Gaoxiang Ma & Peipei Wang & Hua-Mei Xie & Si-Jia Jin & Ting-Ting Wei & Xiang-Yu Yu & Yi Wang & Jun-Yuan Zhang & Ping Li & Lian-Wen Qi & Lei Zhang, 2023. "Neuraminidase 1 promotes renal fibrosis development in male mice," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    3. Shirong Cao & Yu Pan & Andrew S. Terker & Juan Pablo Arroyo Ornelas & Yinqiu Wang & Jiaqi Tang & Aolei Niu & Sarah Abu Kar & Mengdi Jiang & Wentian Luo & Xinyu Dong & Xiaofeng Fan & Suwan Wang & Matth, 2023. "Epidermal growth factor receptor activation is essential for kidney fibrosis development," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    4. Riley D. Metcalfe & Eric Hanssen & Ka Yee Fung & Kaheina Aizel & Clara C. Kosasih & Courtney O. Zlatic & Larissa Doughty & Craig J. Morton & Andrew P. Leis & Michael W. Parker & Paul R. Gooley & Tracy, 2023. "Structures of the interleukin 11 signalling complex reveal gp130 dynamics and the inhibitory mechanism of a cytokine variant," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    5. Jenniffer Linares & Anna Sallent-Aragay & Jordi Badia-Ramentol & Alba Recort-Bascuas & Ana Méndez & Noemí Manero-Rupérez & Daniele Lo Re & Elisa I. Rivas & Marc Guiu & Melissa Zwick & Mar Iglesias & C, 2023. "Long-term platinum-based drug accumulation in cancer-associated fibroblasts promotes colorectal cancer progression and resistance to therapy," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    6. Jack S. Gisby & Norzawani B. Buang & Artemis Papadaki & Candice L. Clarke & Talat H. Malik & Nicholas Medjeral-Thomas & Damiola Pinheiro & Paige M. Mortimer & Shanice Lewis & Eleanor Sandhu & Stephen , 2022. "Multi-omics identify falling LRRC15 as a COVID-19 severity marker and persistent pro-thrombotic signals in convalescence," Nature Communications, Nature, vol. 13(1), pages 1-21, December.
    7. Benjamin Ng & Kevin Y. Huang & Chee Jian Pua & Sivakumar Viswanathan & Wei-Wen Lim & Fathima F. Kuthubudeen & Yu-Ning Liu & An An Hii & Benjamin L. George & Anissa A. Widjaja & Enrico Petretto & Stuar, 2024. "Interleukin-11 causes alveolar type 2 cell dysfunction and prevents alveolar regeneration," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    8. Yasufumi Katanasaka & Harumi Yabe & Noriyuki Murata & Minori Sobukawa & Yuga Sugiyama & Hikaru Sato & Hiroki Honda & Yoichi Sunagawa & Masafumi Funamoto & Satoshi Shimizu & Kana Shimizu & Toshihide Ha, 2024. "Fibroblast-specific PRMT5 deficiency suppresses cardiac fibrosis and left ventricular dysfunction in male mice," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    9. Anissa A. Widjaja & Sivakumar Viswanathan & Shamini G. Shekeran & Eleonora Adami & Wei-Wen Lim & Sonia Chothani & Jessie Tan & Joyce Wei Ting Goh & Hui Mei Chen & Sze Yun Lim & Carine M. Boustany-Kari, 2022. "Targeting endogenous kidney regeneration using anti-IL11 therapy in acute and chronic models of kidney disease," Nature Communications, Nature, vol. 13(1), pages 1-18, December.

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