IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v552y2017i7683d10.1038_nature24676.html
   My bibliography  Save this article

IL-11 is a crucial determinant of cardiovascular fibrosis

Author

Listed:
  • Sebastian Schafer

    (National Heart Centre Singapore
    Duke–National University of Singapore Medical School)

  • Sivakumar Viswanathan

    (Duke–National University of Singapore Medical School)

  • Anissa A. Widjaja

    (Duke–National University of Singapore Medical School)

  • Wei-Wen Lim

    (National Heart Centre Singapore)

  • Aida Moreno-Moral

    (Duke–National University of Singapore Medical School)

  • Daniel M. DeLaughter

    (Harvard Medical School)

  • Benjamin Ng

    (National Heart Centre Singapore)

  • Giannino Patone

    (Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC))

  • Kingsley Chow

    (National Heart Centre Singapore)

  • Ester Khin

    (Duke–National University of Singapore Medical School)

  • Jessie Tan

    (National Heart Centre Singapore)

  • Sonia P. Chothani

    (Duke–National University of Singapore Medical School)

  • Lei Ye

    (National Heart Centre Singapore)

  • Owen J. L. Rackham

    (Duke–National University of Singapore Medical School)

  • Nicole S. J. Ko

    (Duke–National University of Singapore Medical School)

  • Norliza E. Sahib

    (Duke–National University of Singapore Medical School)

  • Chee Jian Pua

    (National Heart Centre Singapore)

  • Nicole T. G. Zhen

    (National Heart Centre Singapore)

  • Chen Xie

    (National Heart Centre Singapore)

  • Mao Wang

    (Duke–National University of Singapore Medical School)

  • Henrike Maatz

    (Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC))

  • Shiqi Lim

    (National Heart Centre Singapore)

  • Kathrin Saar

    (Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC))

  • Susanne Blachut

    (Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC))

  • Enrico Petretto

    (Duke–National University of Singapore Medical School)

  • Sabine Schmidt

    (Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC))

  • Tracy Putoczki

    (Walter and Eliza Hall Institute of Medical Research
    The University of Melbourne)

  • Nuno Guimarães-Camboa

    (Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego)

  • Hiroko Wakimoto

    (Harvard Medical School)

  • Sebastiaan van Heesch

    (Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC))

  • Kristmundur Sigmundsson

    (Duke–National University of Singapore Medical School)

  • See L. Lim

    (National Heart Centre Singapore)

  • Jia L. Soon

    (National Heart Centre Singapore
    Duke–National University of Singapore Medical School)

  • Victor T. T. Chao

    (National Heart Centre Singapore
    Duke–National University of Singapore Medical School)

  • Yeow L. Chua

    (National Heart Centre Singapore)

  • Teing E. Tan

    (National Heart Centre Singapore)

  • Sylvia M. Evans

    (Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego
    University of California at San Diego
    University of California at San Diego)

  • Yee J. Loh

    (National Heart Centre Singapore
    Kandang Kerbau Women’s and Children’s Hospital)

  • Muhammad H. Jamal

    (National Heart Centre Singapore)

  • Kim K. Ong

    (National Heart Centre Singapore
    Kandang Kerbau Women’s and Children’s Hospital)

  • Kim C. Chua

    (National Heart Centre Singapore)

  • Boon-Hean Ong

    (National Heart Centre Singapore)

  • Mathew J. Chakaramakkil

    (National Heart Centre Singapore)

  • Jonathan G. Seidman

    (Harvard Medical School)

  • Christine E. Seidman

    (Harvard Medical School
    Brigham and Women’s Hospital
    Howard Hughes Medical Institute)

  • Norbert Hubner

    (Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC)
    DZHK (German Centre for Cardiovascular Research)
    Charité-Universitätsmedizin
    Berlin Institute of Health (BIH))

  • Kenny Y. K. Sin

    (National Heart Centre Singapore
    Duke–National University of Singapore Medical School)

  • Stuart A. Cook

    (National Heart Centre Singapore
    Duke–National University of Singapore Medical School
    National Heart and Lung Institute, Imperial College London
    MRC-London Institute of Medical Sciences, Hammersmith Hospital Campus)

Abstract

Fibroblast-specific Il-11 expression causes heart and kidney fibrosis and organ failure, whereas IL-11 inhibition prevents fibroblast activation and organ fibrosis, indicating that IL-11 inhibition is a potential therapeutic strategy to treat fibrotic diseases.

Suggested Citation

  • Sebastian Schafer & Sivakumar Viswanathan & Anissa A. Widjaja & Wei-Wen Lim & Aida Moreno-Moral & Daniel M. DeLaughter & Benjamin Ng & Giannino Patone & Kingsley Chow & Ester Khin & Jessie Tan & Sonia, 2017. "IL-11 is a crucial determinant of cardiovascular fibrosis," Nature, Nature, vol. 552(7683), pages 110-115, December.
  • Handle: RePEc:nat:nature:v:552:y:2017:i:7683:d:10.1038_nature24676
    DOI: 10.1038/nature24676
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature24676
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.

    File URL: https://libkey.io/10.1038/nature24676?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Qian-Qian Chen & Kang Liu & Ning Shi & Gaoxiang Ma & Peipei Wang & Hua-Mei Xie & Si-Jia Jin & Ting-Ting Wei & Xiang-Yu Yu & Yi Wang & Jun-Yuan Zhang & Ping Li & Lian-Wen Qi & Lei Zhang, 2023. "Neuraminidase 1 promotes renal fibrosis development in male mice," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    2. Shirong Cao & Yu Pan & Andrew S. Terker & Juan Pablo Arroyo Ornelas & Yinqiu Wang & Jiaqi Tang & Aolei Niu & Sarah Abu Kar & Mengdi Jiang & Wentian Luo & Xinyu Dong & Xiaofeng Fan & Suwan Wang & Matth, 2023. "Epidermal growth factor receptor activation is essential for kidney fibrosis development," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    3. Jack S. Gisby & Norzawani B. Buang & Artemis Papadaki & Candice L. Clarke & Talat H. Malik & Nicholas Medjeral-Thomas & Damiola Pinheiro & Paige M. Mortimer & Shanice Lewis & Eleanor Sandhu & Stephen , 2022. "Multi-omics identify falling LRRC15 as a COVID-19 severity marker and persistent pro-thrombotic signals in convalescence," Nature Communications, Nature, vol. 13(1), pages 1-21, December.
    4. Yasufumi Katanasaka & Harumi Yabe & Noriyuki Murata & Minori Sobukawa & Yuga Sugiyama & Hikaru Sato & Hiroki Honda & Yoichi Sunagawa & Masafumi Funamoto & Satoshi Shimizu & Kana Shimizu & Toshihide Ha, 2024. "Fibroblast-specific PRMT5 deficiency suppresses cardiac fibrosis and left ventricular dysfunction in male mice," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    5. Tao Zhuang & Mei-Hua Chen & Ruo-Xi Wu & Jing Wang & Xi-De Hu & Ting Meng & Ai-Hua Wu & Yan Li & Yong-Feng Yang & Yu Lei & Dong-Hua Hu & Yan-Xiu Li & Li Zhang & Ai-Jun Sun & Wei Lu & Guan-Nan Zhang & J, 2024. "ALKBH5-mediated m6A modification of IL-11 drives macrophage-to-myofibroblast transition and pathological cardiac fibrosis in mice," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    6. Riley D. Metcalfe & Eric Hanssen & Ka Yee Fung & Kaheina Aizel & Clara C. Kosasih & Courtney O. Zlatic & Larissa Doughty & Craig J. Morton & Andrew P. Leis & Michael W. Parker & Paul R. Gooley & Tracy, 2023. "Structures of the interleukin 11 signalling complex reveal gp130 dynamics and the inhibitory mechanism of a cytokine variant," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    7. Jenniffer Linares & Anna Sallent-Aragay & Jordi Badia-Ramentol & Alba Recort-Bascuas & Ana Méndez & Noemí Manero-Rupérez & Daniele Lo Re & Elisa I. Rivas & Marc Guiu & Melissa Zwick & Mar Iglesias & C, 2023. "Long-term platinum-based drug accumulation in cancer-associated fibroblasts promotes colorectal cancer progression and resistance to therapy," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    8. Benjamin Ng & Kevin Y. Huang & Chee Jian Pua & Sivakumar Viswanathan & Wei-Wen Lim & Fathima F. Kuthubudeen & Yu-Ning Liu & An An Hii & Benjamin L. George & Anissa A. Widjaja & Enrico Petretto & Stuar, 2024. "Interleukin-11 causes alveolar type 2 cell dysfunction and prevents alveolar regeneration," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    9. Anissa A. Widjaja & Sivakumar Viswanathan & Shamini G. Shekeran & Eleonora Adami & Wei-Wen Lim & Sonia Chothani & Jessie Tan & Joyce Wei Ting Goh & Hui Mei Chen & Sze Yun Lim & Carine M. Boustany-Kari, 2022. "Targeting endogenous kidney regeneration using anti-IL11 therapy in acute and chronic models of kidney disease," Nature Communications, Nature, vol. 13(1), pages 1-18, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:552:y:2017:i:7683:d:10.1038_nature24676. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.