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Structure of the human MHC-I peptide-loading complex

Author

Listed:
  • Andreas Blees

    (Institute of Biochemistry, Biocenter, Goethe University Frankfurt)

  • Dovile Januliene

    (Max Planck Institute of Biophysics)

  • Tommy Hofmann

    (Interdisciplinary Research Center HALOmen, Martin Luther University Halle-Wittenberg)

  • Nicole Koller

    (Institute of Biochemistry, Biocenter, Goethe University Frankfurt)

  • Carla Schmidt

    (Interdisciplinary Research Center HALOmen, Martin Luther University Halle-Wittenberg)

  • Simon Trowitzsch

    (Institute of Biochemistry, Biocenter, Goethe University Frankfurt)

  • Arne Moeller

    (Max Planck Institute of Biophysics)

  • Robert Tampé

    (Institute of Biochemistry, Biocenter, Goethe University Frankfurt)

Abstract

Electron cryo-microscopy structures of the human peptide-loading complex shed light on its operation and on the onset of adaptive immune responses.

Suggested Citation

  • Andreas Blees & Dovile Januliene & Tommy Hofmann & Nicole Koller & Carla Schmidt & Simon Trowitzsch & Arne Moeller & Robert Tampé, 2017. "Structure of the human MHC-I peptide-loading complex," Nature, Nature, vol. 551(7681), pages 525-528, November.
    • Handle: RePEc:nat:nature:v:551:y:2017:i:7681:d:10.1038_nature24627
    DOI: 10.1038/nature24627
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    Citations

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    Cited by:

    1. Alexander Domnick & Christian Winter & Lukas Sušac & Leon Hennecke & Mario Hensen & Nicole Zitzmann & Simon Trowitzsch & Christoph Thomas & Robert Tampé, 2022. "Molecular basis of MHC I quality control in the peptide loading complex," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    2. Xin Lei & Indu Khatri & Tom Wit & Iris Rink & Marja Nieuwland & Ron Kerkhoven & Hans Eenennaam & Chong Sun & Abhishek D. Garg & Jannie Borst & Yanling Xiao, 2023. "CD4+ helper T cells endow cDC1 with cancer-impeding functions in the human tumor micro-environment," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    3. Lenong Li & Xubiao Peng & Mansoor Batliwala & Marlene Bouvier, 2023. "Crystal structures of MHC class I complexes reveal the elusive intermediate conformations explored during peptide editing," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    4. Jiansheng Jiang & Daniel K. Taylor & Ellen J. Kim & Lisa F. Boyd & Javeed Ahmad & Michael G. Mage & Hau V. Truong & Claire H. Woodward & Nikolaos G. Sgourakis & Peter Cresswell & David H. Margulies & , 2022. "Structural mechanism of tapasin-mediated MHC-I peptide loading in antigen presentation," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    5. Ines Katharina Müller & Christian Winter & Christoph Thomas & Robbert M. Spaapen & Simon Trowitzsch & Robert Tampé, 2022. "Structure of an MHC I–tapasin–ERp57 editing complex defines chaperone promiscuity," Nature Communications, Nature, vol. 13(1), pages 1-10, December.

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