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Identification of unique neoantigen qualities in long-term survivors of pancreatic cancer

Author

Listed:
  • Vinod P. Balachandran

    (Memorial Sloan Kettering Cancer Center
    David M. Rubenstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center
    Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center)

  • Marta Łuksza

    (The Simons Center for Systems Biology, Institute for Advanced Study)

  • Julia N. Zhao

    (Memorial Sloan Kettering Cancer Center
    David M. Rubenstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center
    Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center)

  • Vladimir Makarov

    (Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center
    Immunogenomics and Precision Oncology Platform, Memorial Sloan Kettering Cancer Center)

  • John Alec Moral

    (Memorial Sloan Kettering Cancer Center
    David M. Rubenstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center
    Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center)

  • Romain Remark

    (Tisch Cancer Institute, Immunology Institute, Icahn School of Medicine at Mount Sinai)

  • Brian Herbst

    (David M. Rubenstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center)

  • Gokce Askan

    (David M. Rubenstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center
    Memorial Sloan Kettering Cancer Center)

  • Umesh Bhanot

    (Memorial Sloan Kettering Cancer Center)

  • Yasin Senbabaoglu

    (Swim Across America/Ludwig Collaborative Laboratory)

  • Daniel K. Wells

    (Parker Institute for Cancer Immunotherapy)

  • Charles Ian Ormsby Cary

    (Parker Institute for Cancer Immunotherapy)

  • Olivera Grbovic-Huezo

    (David M. Rubenstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center)

  • Marc Attiyeh

    (Memorial Sloan Kettering Cancer Center
    David M. Rubenstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center)

  • Benjamin Medina

    (Memorial Sloan Kettering Cancer Center)

  • Jennifer Zhang

    (Memorial Sloan Kettering Cancer Center)

  • Jennifer Loo

    (Memorial Sloan Kettering Cancer Center)

  • Joseph Saglimbeni

    (David M. Rubenstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center)

  • Mohsen Abu-Akeel

    (Swim Across America/Ludwig Collaborative Laboratory)

  • Roberta Zappasodi

    (Swim Across America/Ludwig Collaborative Laboratory)

  • Nadeem Riaz

    (Immunogenomics and Precision Oncology Platform, Memorial Sloan Kettering Cancer Center
    Memorial Sloan Kettering Cancer Center)

  • Martin Smoragiewicz

    (Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre)

  • Z. Larkin Kelley

    (Cold Spring Harbor Laboratory
    Weill Cornell Medical School)

  • Olca Basturk

    (Memorial Sloan Kettering Cancer Center)

  • Mithat Gönen

    (Memorial Sloan Kettering Cancer Center)

  • Arnold J. Levine

    (The Simons Center for Systems Biology, Institute for Advanced Study)

  • Peter J. Allen

    (Memorial Sloan Kettering Cancer Center
    David M. Rubenstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center)

  • Douglas T. Fearon

    (Cold Spring Harbor Laboratory
    Weill Cornell Medical School)

  • Miriam Merad

    (Tisch Cancer Institute, Immunology Institute, Icahn School of Medicine at Mount Sinai)

  • Sacha Gnjatic

    (Tisch Cancer Institute, Immunology Institute, Icahn School of Medicine at Mount Sinai)

  • Christine A. Iacobuzio-Donahue

    (David M. Rubenstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center
    Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center
    Memorial Sloan Kettering Cancer Center)

  • Jedd D. Wolchok

    (Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center
    Swim Across America/Ludwig Collaborative Laboratory
    Melanoma and Immunotherapeutics Service, Memorial Sloan Kettering Cancer Center
    Weill Cornell Medical College, Cornell University)

  • Ronald P. DeMatteo

    (Memorial Sloan Kettering Cancer Center
    David M. Rubenstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center)

  • Timothy A. Chan

    (Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center
    Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center
    Immunogenomics and Precision Oncology Platform, Memorial Sloan Kettering Cancer Center
    Memorial Sloan Kettering Cancer Center)

  • Benjamin D. Greenbaum

    (Tisch Cancer Institute, Hematology and Medical Oncology, Oncological Sciences, and Pathology, Icahn School of Medicine at Mount Sinai)

  • Taha Merghoub

    (Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center
    Swim Across America/Ludwig Collaborative Laboratory
    Memorial Sloan Kettering Cancer Center)

  • Steven D. Leach

    (Memorial Sloan Kettering Cancer Center
    David M. Rubenstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center
    Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center
    Dartmouth Norris Cotton Cancer Center, Lebanon)

Abstract

The analysis of T-cell antigens in long-term survivors of pancreatic ductal adenocarcinoma suggests that neoantigen immunogenicity and quality, not purely quantity, correlate with survival.

Suggested Citation

  • Vinod P. Balachandran & Marta Łuksza & Julia N. Zhao & Vladimir Makarov & John Alec Moral & Romain Remark & Brian Herbst & Gokce Askan & Umesh Bhanot & Yasin Senbabaoglu & Daniel K. Wells & Charles Ia, 2017. "Identification of unique neoantigen qualities in long-term survivors of pancreatic cancer," Nature, Nature, vol. 551(7681), pages 512-516, November.
    • Handle: RePEc:nat:nature:v:551:y:2017:i:7681:d:10.1038_nature24462
    DOI: 10.1038/nature24462
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    Cited by:

    1. Jeppe Sejerø Holm & Samuel A. Funt & Annie Borch & Kamilla Kjærgaard Munk & Anne-Mette Bjerregaard & James L. Reading & Colleen Maher & Ashley Regazzi & Phillip Wong & Hikmat Al-Ahmadie & Gopa Iyer & , 2022. "Neoantigen-specific CD8 T cell responses in the peripheral blood following PD-L1 blockade might predict therapy outcome in metastatic urothelial carcinoma," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    2. Julien Schmidt & Johanna Chiffelle & Marta A. S. Perez & Morgane Magnin & Sara Bobisse & Marion Arnaud & Raphael Genolet & Julien Cesbron & David Barras & Blanca Navarro Rodrigo & Fabrizio Benedetti &, 2023. "Neoantigen-specific CD8 T cells with high structural avidity preferentially reside in and eliminate tumors," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    3. Haodong Xu & Ruifeng Hu & Xianjun Dong & Lan Kuang & Wenchao Zhang & Chao Tu & Zhihong Li & Zhongming Zhao, 2024. "ImmuneApp for HLA-I epitope prediction and immunopeptidome analysis," Nature Communications, Nature, vol. 15(1), pages 1-15, December.

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