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Glucose feeds the TCA cycle via circulating lactate

Author

Listed:
  • Sheng Hui

    (Lewis-Sigler Institute for Integrative Genomics, Princeton University
    Princeton University)

  • Jonathan M. Ghergurovich

    (Lewis-Sigler Institute for Integrative Genomics, Princeton University
    Princeton University)

  • Raphael J. Morscher

    (Lewis-Sigler Institute for Integrative Genomics, Princeton University
    Princeton University)

  • Cholsoon Jang

    (Lewis-Sigler Institute for Integrative Genomics, Princeton University
    Princeton University)

  • Xin Teng

    (Lewis-Sigler Institute for Integrative Genomics, Princeton University
    Princeton University)

  • Wenyun Lu

    (Lewis-Sigler Institute for Integrative Genomics, Princeton University
    Princeton University)

  • Lourdes A. Esparza

    (Moores Cancer Center, University of California San Diego School of Medicine)

  • Tannishtha Reya

    (Moores Cancer Center, University of California San Diego School of Medicine)

  • Le Zhan

    (Rutgers Cancer Institute of New Jersey
    Rutgers University)

  • Jessie Yanxiang Guo

    (Rutgers Cancer Institute of New Jersey
    Rutgers Robert Wood Johnson Medical School
    Rutgers Ernest Mario School of Pharmacy)

  • Eileen White

    (Rutgers Cancer Institute of New Jersey
    Rutgers University)

  • Joshua D. Rabinowitz

    (Lewis-Sigler Institute for Integrative Genomics, Princeton University
    Princeton University
    Rutgers Cancer Institute of New Jersey)

Abstract

Metabolic flux analysis in mice reveals that lactate often acts as the primary carbon source for the tricarboxylic acid cycle both in normal tissues and in tumour microenvironments.

Suggested Citation

  • Sheng Hui & Jonathan M. Ghergurovich & Raphael J. Morscher & Cholsoon Jang & Xin Teng & Wenyun Lu & Lourdes A. Esparza & Tannishtha Reya & Le Zhan & Jessie Yanxiang Guo & Eileen White & Joshua D. Rabi, 2017. "Glucose feeds the TCA cycle via circulating lactate," Nature, Nature, vol. 551(7678), pages 115-118, November.
    • Handle: RePEc:nat:nature:v:551:y:2017:i:7678:d:10.1038_nature24057
    DOI: 10.1038/nature24057
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    Cited by:

    1. Qiang Feng & Zhida Liu & Xuexin Yu & Tongyi Huang & Jiahui Chen & Jian Wang & Jonathan Wilhelm & Suxin Li & Jiwon Song & Wei Li & Zhichen Sun & Baran D. Sumer & Bo Li & Yang-Xin Fu & Jinming Gao, 2022. "Lactate increases stemness of CD8 + T cells to augment anti-tumor immunity," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    2. Guihong Lu & Xiaojun Wang & Feng Li & Shuang Wang & Jiawei Zhao & Jinyi Wang & Jing Liu & Chengliang Lyu & Peng Ye & Hui Tan & Weiping Li & Guanghui Ma & Wei Wei, 2022. "Engineered biomimetic nanoparticles achieve targeted delivery and efficient metabolism-based synergistic therapy against glioblastoma," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    3. Charlotte M. François & Thomas Pihl & Marion Dunoyer de Segonzac & Chloé Hérault & Bruno Hudry, 2023. "Metabolic regulation of proteome stability via N-terminal acetylation controls male germline stem cell differentiation and reproduction," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    4. Ali Vaziri-Gohar & Jonathan J. Hue & Ata Abbas & Hallie J. Graor & Omid Hajihassani & Mehrdad Zarei & George Titomihelakis & John Feczko & Moeez Rathore & Sylwia Chelstowska & Alexander W. Loftus & Ru, 2023. "Increased glucose availability sensitizes pancreatic cancer to chemotherapy," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    5. Katia Monsorno & Kyllian Ginggen & Andranik Ivanov & An Buckinx & Arnaud L. Lalive & Anna Tchenio & Sam Benson & Marc Vendrell & Angelo D’Alessandro & Dieter Beule & Luc Pellerin & Manuel Mameli & Ros, 2023. "Loss of microglial MCT4 leads to defective synaptic pruning and anxiety-like behavior in mice," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    6. Xueman Chen & Rong Luo & Yunmei Zhang & Shuying Ye & Xin Zeng & Jiang Liu & Di Huang & Yujie Liu & Qiang Liu & Man-Li Luo & Erwei Song, 2022. "Long noncoding RNA DIO3OS induces glycolytic-dominant metabolic reprogramming to promote aromatase inhibitor resistance in breast cancer," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    7. Dorothy Koveal & Paul C. Rosen & Dylan J. Meyer & Carlos Manlio Díaz-García & Yongcheng Wang & Li-Heng Cai & Peter J. Chou & David A. Weitz & Gary Yellen, 2022. "A high-throughput multiparameter screen for accelerated development and optimization of soluble genetically encoded fluorescent biosensors," Nature Communications, Nature, vol. 13(1), pages 1-14, December.

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