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Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15

Author

Listed:
  • Jer-Yuan Hsu

    (NGM Biopharmaceuticals)

  • Suzanne Crawley

    (NGM Biopharmaceuticals)

  • Michael Chen

    (NGM Biopharmaceuticals)

  • Dina A. Ayupova

    (NGM Biopharmaceuticals)

  • Darrin A. Lindhout

    (NGM Biopharmaceuticals)

  • Jared Higbee

    (NGM Biopharmaceuticals)

  • Alan Kutach

    (NGM Biopharmaceuticals)

  • William Joo

    (NGM Biopharmaceuticals
    Harvard University)

  • Zhengyu Gao

    (NGM Biopharmaceuticals)

  • Diana Fu

    (NGM Biopharmaceuticals)

  • Carmen To

    (NGM Biopharmaceuticals)

  • Kalyani Mondal

    (NGM Biopharmaceuticals)

  • Betty Li

    (NGM Biopharmaceuticals)

  • Avantika Kekatpure

    (NGM Biopharmaceuticals)

  • Marilyn Wang

    (NGM Biopharmaceuticals)

  • Teresa Laird

    (NGM Biopharmaceuticals)

  • Geoffrey Horner

    (NGM Biopharmaceuticals)

  • Jackie Chan

    (NGM Biopharmaceuticals)

  • Michele McEntee

    (NGM Biopharmaceuticals)

  • Manuel Lopez

    (NGM Biopharmaceuticals
    BioMarin Pharmaceuticals Inc.)

  • Damodharan Lakshminarasimhan

    (XTAL Biostructures)

  • Andre White

    (XTAL Biostructures)

  • Sheng-Ping Wang

    (Merck Research Labs)

  • Jun Yao

    (Merck Research Labs)

  • Junming Yie

    (Merck Research Labs)

  • Hugo Matern

    (NGM Biopharmaceuticals)

  • Mark Solloway

    (NGM Biopharmaceuticals)

  • Raj Haldankar

    (NGM Biopharmaceuticals)

  • Thomas Parsons

    (NGM Biopharmaceuticals)

  • Jie Tang

    (NGM Biopharmaceuticals)

  • Wenyan D. Shen

    (NGM Biopharmaceuticals)

  • Yu Alice Chen

    (NGM Biopharmaceuticals
    23andMe, Inc.)

  • Hui Tian

    (NGM Biopharmaceuticals)

  • Bernard B. Allan

    (NGM Biopharmaceuticals)

Abstract

GDNF receptor alpha-like is a brainstem-restricted receptor for growth and differentiation factor 15, regulating appetite and body weight in non-homeostatic conditions by activating the emergency circuit response to disease and toxin stresses.

Suggested Citation

  • Jer-Yuan Hsu & Suzanne Crawley & Michael Chen & Dina A. Ayupova & Darrin A. Lindhout & Jared Higbee & Alan Kutach & William Joo & Zhengyu Gao & Diana Fu & Carmen To & Kalyani Mondal & Betty Li & Avant, 2017. "Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15," Nature, Nature, vol. 550(7675), pages 255-259, October.
    • Handle: RePEc:nat:nature:v:550:y:2017:i:7675:d:10.1038_nature24042
    DOI: 10.1038/nature24042
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    Citations

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    Cited by:

    1. Xuanming Guo & Pallavi Asthana & Lixiang Zhai & Ka Wing Cheng & Susma Gurung & Jiangang Huang & Jiayan Wu & Yijing Zhang & Arun Kumar Mahato & Mart Saarma & Mart Ustav & Hiu Yee Kwan & Aiping Lyu & Ku, 2024. "Artesunate treats obesity in male mice and non-human primates through GDF15/GFRAL signalling axis," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    2. F. M. Houghton & S. E. Adams & A. S. Ríos & L. Masino & A. G. Purkiss & D. C. Briggs & F. Ledda & N. Q. McDonald, 2023. "Architecture and regulation of a GDNF-GFRα1 synaptic adhesion assembly," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    3. Laurent L’homme & Benan Pelin Sermikli & Joel T. Haas & Sébastien Fleury & Sandrine Quemener & Valentine Guinot & Emelie Barreby & Nathalie Esser & Robert Caiazzo & Hélène Verkindt & Benjamin Legendre, 2024. "Adipose tissue macrophage infiltration and hepatocyte stress increase GDF-15 throughout development of obesity to MASH," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    4. Qingtao Sun & Daniëlle Lisdonk & Miriam Ferrer & Bruno Gegenhuber & Melody Wu & Youngkyu Park & David A. Tuveson & Jessica Tollkuhn & Tobias Janowitz & Bo Li, 2024. "Area postrema neurons mediate interleukin-6 function in cancer cachexia," Nature Communications, Nature, vol. 15(1), pages 1-19, December.

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