IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v550y2017i7675d10.1038_nature24042.html
   My bibliography  Save this article

Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15

Author

Listed:
  • Jer-Yuan Hsu

    (NGM Biopharmaceuticals)

  • Suzanne Crawley

    (NGM Biopharmaceuticals)

  • Michael Chen

    (NGM Biopharmaceuticals)

  • Dina A. Ayupova

    (NGM Biopharmaceuticals)

  • Darrin A. Lindhout

    (NGM Biopharmaceuticals)

  • Jared Higbee

    (NGM Biopharmaceuticals)

  • Alan Kutach

    (NGM Biopharmaceuticals)

  • William Joo

    (NGM Biopharmaceuticals
    Harvard University)

  • Zhengyu Gao

    (NGM Biopharmaceuticals)

  • Diana Fu

    (NGM Biopharmaceuticals)

  • Carmen To

    (NGM Biopharmaceuticals)

  • Kalyani Mondal

    (NGM Biopharmaceuticals)

  • Betty Li

    (NGM Biopharmaceuticals)

  • Avantika Kekatpure

    (NGM Biopharmaceuticals)

  • Marilyn Wang

    (NGM Biopharmaceuticals)

  • Teresa Laird

    (NGM Biopharmaceuticals)

  • Geoffrey Horner

    (NGM Biopharmaceuticals)

  • Jackie Chan

    (NGM Biopharmaceuticals)

  • Michele McEntee

    (NGM Biopharmaceuticals)

  • Manuel Lopez

    (NGM Biopharmaceuticals
    BioMarin Pharmaceuticals Inc.)

  • Damodharan Lakshminarasimhan

    (XTAL Biostructures)

  • Andre White

    (XTAL Biostructures)

  • Sheng-Ping Wang

    (Merck Research Labs)

  • Jun Yao

    (Merck Research Labs)

  • Junming Yie

    (Merck Research Labs)

  • Hugo Matern

    (NGM Biopharmaceuticals)

  • Mark Solloway

    (NGM Biopharmaceuticals)

  • Raj Haldankar

    (NGM Biopharmaceuticals)

  • Thomas Parsons

    (NGM Biopharmaceuticals)

  • Jie Tang

    (NGM Biopharmaceuticals)

  • Wenyan D. Shen

    (NGM Biopharmaceuticals)

  • Yu Alice Chen

    (NGM Biopharmaceuticals
    23andMe, Inc.)

  • Hui Tian

    (NGM Biopharmaceuticals)

  • Bernard B. Allan

    (NGM Biopharmaceuticals)

Abstract

GDNF receptor alpha-like is a brainstem-restricted receptor for growth and differentiation factor 15, regulating appetite and body weight in non-homeostatic conditions by activating the emergency circuit response to disease and toxin stresses.

Suggested Citation

  • Jer-Yuan Hsu & Suzanne Crawley & Michael Chen & Dina A. Ayupova & Darrin A. Lindhout & Jared Higbee & Alan Kutach & William Joo & Zhengyu Gao & Diana Fu & Carmen To & Kalyani Mondal & Betty Li & Avant, 2017. "Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15," Nature, Nature, vol. 550(7675), pages 255-259, October.
    • Handle: RePEc:nat:nature:v:550:y:2017:i:7675:d:10.1038_nature24042
    DOI: 10.1038/nature24042
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature24042
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature24042?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. F. M. Houghton & S. E. Adams & A. S. Ríos & L. Masino & A. G. Purkiss & D. C. Briggs & F. Ledda & N. Q. McDonald, 2023. "Architecture and regulation of a GDNF-GFRα1 synaptic adhesion assembly," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    2. Xuanming Guo & Pallavi Asthana & Lixiang Zhai & Ka Wing Cheng & Susma Gurung & Jiangang Huang & Jiayan Wu & Yijing Zhang & Arun Kumar Mahato & Mart Saarma & Mart Ustav & Hiu Yee Kwan & Aiping Lyu & Ku, 2024. "Artesunate treats obesity in male mice and non-human primates through GDF15/GFRAL signalling axis," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    3. Laurent L’homme & Benan Pelin Sermikli & Joel T. Haas & Sébastien Fleury & Sandrine Quemener & Valentine Guinot & Emelie Barreby & Nathalie Esser & Robert Caiazzo & Hélène Verkindt & Benjamin Legendre, 2024. "Adipose tissue macrophage infiltration and hepatocyte stress increase GDF-15 throughout development of obesity to MASH," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    4. Qingtao Sun & Daniëlle Lisdonk & Miriam Ferrer & Bruno Gegenhuber & Melody Wu & Youngkyu Park & David A. Tuveson & Jessica Tollkuhn & Tobias Janowitz & Bo Li, 2024. "Area postrema neurons mediate interleukin-6 function in cancer cachexia," Nature Communications, Nature, vol. 15(1), pages 1-19, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:550:y:2017:i:7675:d:10.1038_nature24042. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.