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Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours

Author

Listed:
  • Loren M. Lasko

    (Discovery, Global Pharmaceutical Research and Development)

  • Clarissa G. Jakob

    (Discovery, Global Pharmaceutical Research and Development)

  • Rohinton P. Edalji

    (Discovery, Global Pharmaceutical Research and Development)

  • Wei Qiu

    (Discovery, Global Pharmaceutical Research and Development)

  • Debra Montgomery

    (Discovery, Global Pharmaceutical Research and Development)

  • Enrico L. Digiammarino

    (Discovery, Global Pharmaceutical Research and Development)

  • T. Matt Hansen

    (Discovery, Global Pharmaceutical Research and Development)

  • Roberto M. Risi

    (Discovery, Global Pharmaceutical Research and Development)

  • Robin Frey

    (Discovery, Global Pharmaceutical Research and Development)

  • Vlasios Manaves

    (Discovery, Global Pharmaceutical Research and Development)

  • Bailin Shaw

    (Discovery, Global Pharmaceutical Research and Development)

  • Mikkel Algire

    (Discovery, Global Pharmaceutical Research and Development)

  • Paul Hessler

    (Discovery, Global Pharmaceutical Research and Development)

  • Lloyd T. Lam

    (Discovery, Global Pharmaceutical Research and Development)

  • Tamar Uziel

    (Discovery, Global Pharmaceutical Research and Development)

  • Emily Faivre

    (Discovery, Global Pharmaceutical Research and Development)

  • Debra Ferguson

    (Discovery, Global Pharmaceutical Research and Development)

  • Fritz G. Buchanan

    (Discovery, Global Pharmaceutical Research and Development)

  • Ruth L. Martin

    (Discovery, Global Pharmaceutical Research and Development)

  • Maricel Torrent

    (Discovery, Global Pharmaceutical Research and Development)

  • Gary G. Chiang

    (Discovery, Global Pharmaceutical Research and Development
    eFFECTOR Therapeutics)

  • Kannan Karukurichi

    (Petra Pharma Corporation)

  • J. William Langston

    (Faraday Pharmaceuticals, 1616 Eastlake Ave E.)

  • Brian T. Weinert

    (the Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen)

  • Chunaram Choudhary

    (the Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen)

  • Peter de Vries

    (Cascadian Therapeutics, Inc., 2601 Fourth Avenue)

  • Arthur F. Kluge

    (I-to-D, Inc.)

  • Michael A. Patane

    (Mitobridge, Inc.)

  • John H. Van Drie

    (Van Drie Research, 109 Millpond)

  • Ce Wang

    (China Novartis In stitutes for BioMedical Research)

  • David McElligott

    (Accelerator Corporation)

  • Ed Kesicki

    (Petra Pharma Corporation)

  • Ronen Marmorstein

    (Perelman School of Medicine, University of Pennsylvania)

  • Chaohong Sun

    (Discovery, Global Pharmaceutical Research and Development)

  • Philip A. Cole

    (Johns Hopkins University)

  • Saul H. Rosenberg

    (Discovery, Global Pharmaceutical Research and Development)

  • Michael R. Michaelides

    (Discovery, Global Pharmaceutical Research and Development)

  • Albert Lai

    (Discovery, Global Pharmaceutical Research and Development)

  • Kenneth D. Bromberg

    (Discovery, Global Pharmaceutical Research and Development)

Abstract

A potent and selective catalytic inhibitor of p300/CBP histone acetyltransferases suppresses tumour proliferation across multiple cell lineages, illustrating the therapeutic potential of drug-like small molecules that target histone acetyltransferases.

Suggested Citation

  • Loren M. Lasko & Clarissa G. Jakob & Rohinton P. Edalji & Wei Qiu & Debra Montgomery & Enrico L. Digiammarino & T. Matt Hansen & Roberto M. Risi & Robin Frey & Vlasios Manaves & Bailin Shaw & Mikkel A, 2017. "Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours," Nature, Nature, vol. 550(7674), pages 128-132, October.
    • Handle: RePEc:nat:nature:v:550:y:2017:i:7674:d:10.1038_nature24028
    DOI: 10.1038/nature24028
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    Citations

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    Cited by:

    1. Mariko Sasaki & Daiki Kato & Karin Murakami & Hiroshi Yoshida & Shohei Takase & Tsuguteru Otsubo & Hideaki Ogiwara, 2024. "Targeting dependency on a paralog pair of CBP/p300 against de-repression of KREMEN2 in SMARCB1-deficient cancers," Nature Communications, Nature, vol. 15(1), pages 1-24, December.
    2. Cheng Zeng & Jiwei Chen & Emmalee W. Cooke & Arijita Subuddhi & Eliana T. Roodman & Fei Xavier Chen & Kaixiang Cao, 2023. "Demethylase-independent roles of LSD1 in regulating enhancers and cell fate transition," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    3. Noha A. M. Shendy & Melissa Bikowitz & Logan H. Sigua & Yang Zhang & Audrey Mercier & Yousef Khashana & Stephanie Nance & Qi Liu & Ian M. Delahunty & Sarah Robinson & Vanshita Goel & Matthew G. Rees &, 2024. "Group 3 medulloblastoma transcriptional networks collapse under domain specific EP300/CBP inhibition," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    4. Elizabeth A. R. Garfinkle & Pratima Nallagatla & Binay Sahoo & Jinjun Dang & Mohammad Balood & Anitria Cotton & Camryn Franke & Sharnise Mitchell & Taylor Wilson & Tanja A. Gruber, 2024. "CBFA2T3-GLIS2 mediates transcriptional regulation of developmental pathways through a gene regulatory network," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

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