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How type II CRISPR–Cas establish immunity through Cas1–Cas2-mediated spacer integration

Author

Listed:
  • Yibei Xiao

    (Cornell University)

  • Sherwin Ng

    (Cornell University)

  • Ki Hyun Nam

    (Pohang Accelerator Laboratory, Pohang University of Science and Technology)

  • Ailong Ke

    (Cornell University)

Abstract

Several structures of the Enteroccocus faecalis Cas1–Cas2 proteins are solved, and help to define the spacer integration mechanisms of type II CRISPR systems.

Suggested Citation

  • Yibei Xiao & Sherwin Ng & Ki Hyun Nam & Ailong Ke, 2017. "How type II CRISPR–Cas establish immunity through Cas1–Cas2-mediated spacer integration," Nature, Nature, vol. 550(7674), pages 137-141, October.
    • Handle: RePEc:nat:nature:v:550:y:2017:i:7674:d:10.1038_nature24020
    DOI: 10.1038/nature24020
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    Cited by:

    1. Julia Koehler Leman & Pawel Szczerbiak & P. Douglas Renfrew & Vladimir Gligorijevic & Daniel Berenberg & Tommi Vatanen & Bryn C. Taylor & Chris Chandler & Stefan Janssen & Andras Pataki & Nick Carrier, 2023. "Sequence-structure-function relationships in the microbial protein universe," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    2. Mingfang Bi & Wenjing Su & Jiafu Li & Xiaobing Mo, 2024. "Insights into the inhibition of protospacer integration via direct interaction between Cas2 and AcrVA5," Nature Communications, Nature, vol. 15(1), pages 1-12, December.

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