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cGAS senses long and HMGB/TFAM-bound U-turn DNA by forming protein–DNA ladders

Author

Listed:
  • Liudmila Andreeva

    (Ludwig-Maximilians-Universität München
    Gene Center, Ludwig-Maximilians-Universität München)

  • Björn Hiller

    (Ludwig-Maximilians-Universität München
    Gene Center, Ludwig-Maximilians-Universität München)

  • Dirk Kostrewa

    (Ludwig-Maximilians-Universität München
    Gene Center, Ludwig-Maximilians-Universität München)

  • Charlotte Lässig

    (Ludwig-Maximilians-Universität München
    Gene Center, Ludwig-Maximilians-Universität München)

  • Carina C. de Oliveira Mann

    (Ludwig-Maximilians-Universität München
    Gene Center, Ludwig-Maximilians-Universität München
    Dana-Farber Cancer Institute, Harvard Medical School)

  • David Jan Drexler

    (Ludwig-Maximilians-Universität München
    Gene Center, Ludwig-Maximilians-Universität München)

  • Andreas Maiser

    (Ludwig-Maximilians-Universität München)

  • Moritz Gaidt

    (Ludwig-Maximilians-Universität München
    Gene Center, Ludwig-Maximilians-Universität München)

  • Heinrich Leonhardt

    (Ludwig-Maximilians-Universität München
    Center for Integrated Protein Science Munich)

  • Veit Hornung

    (Ludwig-Maximilians-Universität München
    Gene Center, Ludwig-Maximilians-Universität München
    Center for Integrated Protein Science Munich)

  • Karl-Peter Hopfner

    (Ludwig-Maximilians-Universität München
    Gene Center, Ludwig-Maximilians-Universität München
    Center for Integrated Protein Science Munich)

Abstract

A molecular mechanism for the sensitive detection of long and U-turn DNA by cyclic GMP–AMP synthase (cGAS) both in vitro and in human cells.

Suggested Citation

  • Liudmila Andreeva & Björn Hiller & Dirk Kostrewa & Charlotte Lässig & Carina C. de Oliveira Mann & David Jan Drexler & Andreas Maiser & Moritz Gaidt & Heinrich Leonhardt & Veit Hornung & Karl-Peter Ho, 2017. "cGAS senses long and HMGB/TFAM-bound U-turn DNA by forming protein–DNA ladders," Nature, Nature, vol. 549(7672), pages 394-398, September.
    • Handle: RePEc:nat:nature:v:549:y:2017:i:7672:d:10.1038_nature23890
    DOI: 10.1038/nature23890
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    Citations

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    Cited by:

    1. Tian-Chen Xiong & Ming-Cong Wei & Fang-Xu Li & Miao Shi & Hu Gan & Zhen Tang & Hong-Peng Dong & Tianzi Liuyu & Pu Gao & Bo Zhong & Zhi-Dong Zhang & Dandan Lin, 2022. "The E3 ubiquitin ligase ARIH1 promotes antiviral immunity and autoimmunity by inducing mono-ISGylation and oligomerization of cGAS," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    2. Lina Wang & Siru Li & Kai Wang & Na Wang & Qiaoling Liu & Zhen Sun & Li Wang & Lulu Wang & Quentin Liu & Chengli Song & Caigang Liu & Qingkai Yang, 2022. "DNA mechanical flexibility controls DNA potential to activate cGAS-mediated immune surveillance," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    3. Shuai Wu & Sandra B. Gabelli & Jungsan Sohn, 2024. "The structural basis for 2′−5′/3′−5′-cGAMP synthesis by cGAS," Nature Communications, Nature, vol. 15(1), pages 1-13, December.

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