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Hippocampal LTP and contextual learning require surface diffusion of AMPA receptors

Author

Listed:
  • A. C. Penn

    (University of Bordeaux, Interdisciplinary Institute for Neuroscience
    CNRS, Interdisciplinary Institute for Neuroscience
    Sussex Neuroscience, School of Life Sciences, University of Sussex)

  • C. L. Zhang

    (University of Bordeaux, Interdisciplinary Institute for Neuroscience
    CNRS, Interdisciplinary Institute for Neuroscience)

  • F. Georges

    (University of Bordeaux, Interdisciplinary Institute for Neuroscience
    CNRS, Interdisciplinary Institute for Neuroscience
    University of Bordeaux, Institute of Neurodegenerative Diseases, CNRS UMR 5293)

  • L. Royer

    (University of Bordeaux, Interdisciplinary Institute for Neuroscience
    CNRS, Interdisciplinary Institute for Neuroscience
    Brandeis University)

  • C. Breillat

    (University of Bordeaux, Interdisciplinary Institute for Neuroscience
    CNRS, Interdisciplinary Institute for Neuroscience)

  • E. Hosy

    (University of Bordeaux, Interdisciplinary Institute for Neuroscience
    CNRS, Interdisciplinary Institute for Neuroscience)

  • J. D. Petersen

    (University of Bordeaux, Interdisciplinary Institute for Neuroscience
    CNRS, Interdisciplinary Institute for Neuroscience
    Bordeaux Imaging Center, UMS 3420 CNRS, US4 INSERM, University of Bordeaux)

  • Y. Humeau

    (University of Bordeaux, Interdisciplinary Institute for Neuroscience
    CNRS, Interdisciplinary Institute for Neuroscience)

  • D. Choquet

    (University of Bordeaux, Interdisciplinary Institute for Neuroscience
    CNRS, Interdisciplinary Institute for Neuroscience
    Bordeaux Imaging Center, UMS 3420 CNRS, US4 INSERM, University of Bordeaux)

Abstract

Surface diffusion of AMPA receptors, from extra-synaptic to synaptic sites at the plasma membrane, is essential for full long-term potentiation in hippocampal neurons and for fear conditioning in living mice.

Suggested Citation

  • A. C. Penn & C. L. Zhang & F. Georges & L. Royer & C. Breillat & E. Hosy & J. D. Petersen & Y. Humeau & D. Choquet, 2017. "Hippocampal LTP and contextual learning require surface diffusion of AMPA receptors," Nature, Nature, vol. 549(7672), pages 384-388, September.
    • Handle: RePEc:nat:nature:v:549:y:2017:i:7672:d:10.1038_nature23658
    DOI: 10.1038/nature23658
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    Cited by:

    1. Hajer El Oussini & Chun-Lei Zhang & Urielle François & Cecilia Castelli & Aurélie Lampin-Saint-Amaux & Marilyn Lepleux & Pablo Molle & Legeolas Velez & Cyril Dejean & Frederic Lanore & Cyril Herry & D, 2023. "CA3 hippocampal synaptic plasticity supports ripple physiology during memory consolidation," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    2. Martin Hruska & Rachel E. Cain & Matthew B. Dalva, 2022. "Nanoscale rules governing the organization of glutamate receptors in spine synapses are subunit specific," Nature Communications, Nature, vol. 13(1), pages 1-19, December.

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