IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v14y2023i1d10.1038_s41467-023-42969-x.html
   My bibliography  Save this article

CA3 hippocampal synaptic plasticity supports ripple physiology during memory consolidation

Author

Listed:
  • Hajer El Oussini

    (University of Bordeaux, CNRS, IINS)

  • Chun-Lei Zhang

    (University of Bordeaux, CNRS, IINS
    Sorbonne Université, CNRS, INSERM, Institut de Biologie Paris Seine (IBPS), Neurosciences Paris Seine (NPS), Team Synaptic Plasticity and Neural Networks)

  • Urielle François

    (University of Bordeaux, CNRS, IINS)

  • Cecilia Castelli

    (University of Bordeaux, CNRS, IINS)

  • Aurélie Lampin-Saint-Amaux

    (University of Bordeaux, CNRS, IINS)

  • Marilyn Lepleux

    (University of Bordeaux, CNRS, IINS)

  • Pablo Molle

    (University of Bordeaux, CNRS, IINS)

  • Legeolas Velez

    (University of Bordeaux, CNRS, IINS)

  • Cyril Dejean

    (University of Bordeaux, INSERM, Neurocentre Magendie)

  • Frederic Lanore

    (University of Bordeaux, CNRS, IINS)

  • Cyril Herry

    (University of Bordeaux, INSERM, Neurocentre Magendie)

  • Daniel Choquet

    (University of Bordeaux, CNRS, IINS)

  • Yann Humeau

    (University of Bordeaux, CNRS, IINS)

Abstract

The consolidation of recent memories depends on memory replays, also called ripples, generated within the hippocampus during slow-wave sleep, and whose inactivation leads to memory impairment. For now, the mobilisation, localisation and importance of synaptic plasticity events associated to ripples are largely unknown. To tackle this question, we used cell surface AMPAR immobilisation to block post-synaptic LTP within the hippocampal region of male mice during a spatial memory task, and show that: 1- hippocampal synaptic plasticity is engaged during consolidation, but is dispensable during encoding or retrieval. 2- Plasticity blockade during sleep results in apparent forgetting of the encoded rule. 3- In vivo ripple recordings show a strong effect of AMPAR immobilisation when a rule has been recently encoded. 4- In situ investigation suggests that plasticity at CA3-CA3 recurrent synapses supports ripple generation. We thus propose that post-synaptic AMPAR mobility at CA3 recurrent synapses is necessary for ripple-dependent rule consolidation.

Suggested Citation

  • Hajer El Oussini & Chun-Lei Zhang & Urielle François & Cecilia Castelli & Aurélie Lampin-Saint-Amaux & Marilyn Lepleux & Pablo Molle & Legeolas Velez & Cyril Dejean & Frederic Lanore & Cyril Herry & D, 2023. "CA3 hippocampal synaptic plasticity supports ripple physiology during memory consolidation," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-42969-x
    DOI: 10.1038/s41467-023-42969-x
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-023-42969-x
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-023-42969-x?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. A. C. Penn & C. L. Zhang & F. Georges & L. Royer & C. Breillat & E. Hosy & J. D. Petersen & Y. Humeau & D. Choquet, 2017. "Hippocampal LTP and contextual learning require surface diffusion of AMPA receptors," Nature, Nature, vol. 549(7672), pages 384-388, September.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Martin Hruska & Rachel E. Cain & Matthew B. Dalva, 2022. "Nanoscale rules governing the organization of glutamate receptors in spine synapses are subunit specific," Nature Communications, Nature, vol. 13(1), pages 1-19, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-42969-x. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.