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CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity

Author

Listed:
  • Marian L. Burr

    (Peter MacCallum Cancer Centre
    University of Melbourne
    Cambridge Institute for Medical Research, Cambridge Biomedical Campus)

  • Christina E. Sparbier

    (Peter MacCallum Cancer Centre)

  • Yih-Chih Chan

    (Peter MacCallum Cancer Centre)

  • James C. Williamson

    (Cambridge Institute for Medical Research, Cambridge Biomedical Campus)

  • Katherine Woods

    (School of Cancer Medicine, La Trobe University
    Olivia Newton-John Cancer Research Institute)

  • Paul A. Beavis

    (Peter MacCallum Cancer Centre
    University of Melbourne)

  • Enid Y. N. Lam

    (Peter MacCallum Cancer Centre
    University of Melbourne)

  • Melissa A. Henderson

    (Peter MacCallum Cancer Centre
    University of Melbourne)

  • Charles C. Bell

    (Peter MacCallum Cancer Centre
    University of Melbourne)

  • Sabine Stolzenburg

    (Peter MacCallum Cancer Centre)

  • Omer Gilan

    (Peter MacCallum Cancer Centre
    University of Melbourne)

  • Stuart Bloor

    (Cambridge Institute for Medical Research, Cambridge Biomedical Campus)

  • Tahereh Noori

    (Peter MacCallum Cancer Centre)

  • David W. Morgens

    (Stanford University)

  • Michael C. Bassik

    (Stanford University)

  • Paul J. Neeson

    (Peter MacCallum Cancer Centre
    University of Melbourne)

  • Andreas Behren

    (School of Cancer Medicine, La Trobe University
    Olivia Newton-John Cancer Research Institute)

  • Phillip K. Darcy

    (Peter MacCallum Cancer Centre
    University of Melbourne)

  • Sarah-Jane Dawson

    (Peter MacCallum Cancer Centre
    University of Melbourne
    Centre for Cancer Research, University of Melbourne)

  • Ilia Voskoboinik

    (Peter MacCallum Cancer Centre
    University of Melbourne)

  • Joseph A. Trapani

    (Peter MacCallum Cancer Centre
    University of Melbourne)

  • Jonathan Cebon

    (School of Cancer Medicine, La Trobe University
    Olivia Newton-John Cancer Research Institute)

  • Paul J. Lehner

    (Cambridge Institute for Medical Research, Cambridge Biomedical Campus)

  • Mark A. Dawson

    (Peter MacCallum Cancer Centre
    University of Melbourne
    Centre for Cancer Research, University of Melbourne
    Peter MacCallum Cancer Centre)

Abstract

CMTM6 maintains PD-L1 at the plasma membrane by inhibiting its lysosome-mediated degradation and promoting its recycling.

Suggested Citation

  • Marian L. Burr & Christina E. Sparbier & Yih-Chih Chan & James C. Williamson & Katherine Woods & Paul A. Beavis & Enid Y. N. Lam & Melissa A. Henderson & Charles C. Bell & Sabine Stolzenburg & Omer Gi, 2017. "CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity," Nature, Nature, vol. 549(7670), pages 101-105, September.
    • Handle: RePEc:nat:nature:v:549:y:2017:i:7670:d:10.1038_nature23643
    DOI: 10.1038/nature23643
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    Cited by:

    1. Marcel P. Trefny & Nicole Kirchhammer & Priska Auf der Maur & Marina Natoli & Dominic Schmid & Markus Germann & Laura Fernandez Rodriguez & Petra Herzig & Jonas Lötscher & Maryam Akrami & Jane C. Stin, 2023. "Deletion of SNX9 alleviates CD8 T cell exhaustion for effective cellular cancer immunotherapy," Nature Communications, Nature, vol. 14(1), pages 1-21, December.
    2. Wenfeng Ren & Zilong Xu & Yating Chang & Fei Ju & Hongning Wu & Zhiqi Liang & Min Zhao & Naizhen Wang & Yanhua Lin & Chenhang Xu & Shengming Chen & Yipeng Rao & Chaolong Lin & Jianxin Yang & Pingguo L, 2024. "Pharmaceutical targeting of OTUB2 sensitizes tumors to cytotoxic T cells via degradation of PD-L1," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    3. Lei Guan & Bin Wu & Ting Li & Lynn A. Beer & Gaurav Sharma & Mingyue Li & Chin Nien Lee & Shujing Liu & Changsong Yang & Lili Huang & Dennie T. Frederick & Genevieve M. Boland & Guangcan Shao & Tatyan, 2022. "HRS phosphorylation drives immunosuppressive exosome secretion and restricts CD8+ T-cell infiltration into tumors," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    4. Qing Li & Liren Zhang & Wenhua You & Jiali Xu & Jingjing Dai & Dongxu Hua & Ruizhi Zhang & Feifan Yao & Suiqing Zhou & Wei Huang & Yongjiu Dai & Yu Zhang & Tasiken Baheti & Xiaofeng Qian & Liyong Pu &, 2022. "PRDM1/BLIMP1 induces cancer immune evasion by modulating the USP22-SPI1-PD-L1 axis in hepatocellular carcinoma cells," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    5. Wenjun Xiong & Xueliang Gao & Tiantian Zhang & Baishan Jiang & Ming-Ming Hu & Xia Bu & Yang Gao & Lin-Zhou Zhang & Bo-Lin Xiao & Chuan He & Yishuang Sun & Haiou Li & Jie Shi & Xiangling Xiao & Bolin X, 2022. "USP8 inhibition reshapes an inflamed tumor microenvironment that potentiates the immunotherapy," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    6. Di-Ao Liu & Kai Tao & Bin Wu & Ziyan Yu & Malwina Szczepaniak & Matthew Rames & Changsong Yang & Tatyana Svitkina & Yueyao Zhu & Fengyuan Xu & Xiaolin Nan & Wei Guo, 2023. "A phosphoinositide switch mediates exocyst recruitment to multivesicular endosomes for exosome secretion," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    7. Yidan Xu & Guowen Jia & Tingting Li & Zixuan Zhou & Yitian Luo & Yulin Chao & Juan Bao & Zhaoming Su & Qianhui Qu & Dianfan Li, 2022. "Molecular insights into biogenesis of glycosylphosphatidylinositol anchor proteins," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    8. Bo Jiang & Xiaozhi Zhao & Wei Chen & Wenli Diao & Meng Ding & Haixiang Qin & Binghua Li & Wenmin Cao & Wei Chen & Yao Fu & Kuiqiang He & Jie Gao & Mengxia Chen & Tingsheng Lin & Yongming Deng & Chao Y, 2022. "Lysosomal protein transmembrane 5 promotes lung-specific metastasis by regulating BMPR1A lysosomal degradation," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    9. Lei Xia & Anastasia Komissarova & Arielle Jacover & Yehuda Shovman & Sebastian Arcila-Barrera & Sharona Tornovsky-Babeay & Milsee Mol Jaya Prakashan & Abdelmajeed Nasereddin & Inbar Plaschkes & Yuval , 2023. "Systematic identification of gene combinations to target in innate immune cells to enhance T cell activation," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    10. Baiwen Chen & Jiajia Hu & Xianting Hu & Huifang Chen & Rujuan Bao & Yatao Zhou & Youqiong Ye & Meixiao Zhan & Wei Cai & Huabin Li & Hua-Bing Li, 2022. "DENR controls JAK2 translation to induce PD-L1 expression for tumor immune evasion," Nature Communications, Nature, vol. 13(1), pages 1-14, December.

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