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cGAS surveillance of micronuclei links genome instability to innate immunity

Author

Listed:
  • Karen J. Mackenzie

    (MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, The University of Edinburgh)

  • Paula Carroll

    (MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, The University of Edinburgh)

  • Carol-Anne Martin

    (MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, The University of Edinburgh)

  • Olga Murina

    (MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, The University of Edinburgh)

  • Adeline Fluteau

    (MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, The University of Edinburgh)

  • Daniel J. Simpson

    (MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, The University of Edinburgh)

  • Nelly Olova

    (MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, The University of Edinburgh)

  • Hannah Sutcliffe

    (MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, The University of Edinburgh)

  • Jacqueline K. Rainger

    (MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, The University of Edinburgh)

  • Andrea Leitch

    (MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, The University of Edinburgh)

  • Ruby T. Osborn

    (MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, The University of Edinburgh)

  • Ann P. Wheeler

    (MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, The University of Edinburgh)

  • Marcin Nowotny

    (Laboratory of Protein Structure, International Institute of Molecular and Cell Biology)

  • Nick Gilbert

    (MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, The University of Edinburgh)

  • Tamir Chandra

    (MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, The University of Edinburgh)

  • Martin A. M. Reijns

    (MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, The University of Edinburgh)

  • Andrew P. Jackson

    (MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, The University of Edinburgh)

Abstract

The cytoplasmic DNA sensor cGAS detects DNA in ruptured micronuclei and activates an innate immune response.

Suggested Citation

  • Karen J. Mackenzie & Paula Carroll & Carol-Anne Martin & Olga Murina & Adeline Fluteau & Daniel J. Simpson & Nelly Olova & Hannah Sutcliffe & Jacqueline K. Rainger & Andrea Leitch & Ruby T. Osborn & A, 2017. "cGAS surveillance of micronuclei links genome instability to innate immunity," Nature, Nature, vol. 548(7668), pages 461-465, August.
    • Handle: RePEc:nat:nature:v:548:y:2017:i:7668:d:10.1038_nature23449
    DOI: 10.1038/nature23449
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    Citations

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    Cited by:

    1. Albert Stuart Reece & Gary Kenneth Hulse, 2022. "Cannabis- and Substance-Related Epidemiological Patterns of Chromosomal Congenital Anomalies in Europe: Geospatiotemporal and Causal Inferential Study," IJERPH, MDPI, vol. 19(18), pages 1-51, September.
    2. Qing Hu & Jose Espejo Valle-Inclán & Rashmi Dahiya & Alison Guyer & Alice Mazzagatti & Elizabeth G. Maurais & Justin L. Engel & Huiming Lu & Anthony J. Davis & Isidro Cortés-Ciriano & Peter Ly, 2024. "Non-homologous end joining shapes the genomic rearrangement landscape of chromothripsis from mitotic errors," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    3. Yu-Hsuan Chen & Han-Hsiun Chen & Won-Jing Wang & Hsin-Yi Chen & Wei-Syun Huang & Chien-Han Kao & Sin-Rong Lee & Nai Yang Yeat & Ruei-Liang Yan & Shu-Jou Chan & Kuen-Phon Wu & Ruey-Hwa Chen, 2023. "TRABID inhibition activates cGAS/STING-mediated anti-tumor immunity through mitosis and autophagy dysregulation," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    4. Tanaz Sharifnia & Mathias J. Wawer & Amy Goodale & Yenarae Lee & Mariya Kazachkova & Joshua M. Dempster & Sandrine Muller & Joan Levy & Daniel M. Freed & Josh Sommer & Jérémie Kalfon & Francisca Vazqu, 2023. "Mapping the landscape of genetic dependencies in chordoma," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    5. Maritza Puray-Chavez & Jenna E. Eschbach & Ming Xia & Kyle M. LaPak & Qianzi Zhou & Ria Jasuja & Jiehong Pan & Jian Xu & Zixiang Zhou & Shawn Mohammed & Qibo Wang & Dana Q. Lawson & Sanja Djokic & Gao, 2024. "A basally active cGAS-STING pathway limits SARS-CoV-2 replication in a subset of ACE2 positive airway cell models," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    6. Lina Wang & Siru Li & Kai Wang & Na Wang & Qiaoling Liu & Zhen Sun & Li Wang & Lulu Wang & Quentin Liu & Chengli Song & Caigang Liu & Qingkai Yang, 2022. "DNA mechanical flexibility controls DNA potential to activate cGAS-mediated immune surveillance," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    7. Christopher P. Wardlaw & John H. J. Petrini, 2022. "ISG15 conjugation to proteins on nascent DNA mitigates DNA replication stress," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    8. Ramona N. Moro & Uddipta Biswas & Suhas S. Kharat & Filip D. Duzanic & Prosun Das & Maria Stavrou & Maria C. Raso & Raimundo Freire & Arnab Ray Chaudhuri & Shyam K. Sharan & Lorenza Penengo, 2023. "Interferon restores replication fork stability and cell viability in BRCA-defective cells via ISG15," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    9. Francesca Mateo & Zhengcheng He & Lin Mei & Gorka Ruiz de Garibay & Carmen Herranz & Nadia García & Amanda Lorentzian & Alexandra Baiges & Eline Blommaert & Antonio Gómez & Oriol Mirallas & Anna Garri, 2022. "Modification of BRCA1-associated breast cancer risk by HMMR overexpression," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    10. M. J. Gutbrod & B. Roche & J. I. Steinberg & A. A. Lakhani & K. Chang & A. J. Schorn & R. A. Martienssen, 2022. "Dicer promotes genome stability via the bromodomain transcriptional co-activator BRD4," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    11. Dario Zimmerli & Chiara S. Brambillasca & Francien Talens & Jinhyuk Bhin & Renske Linstra & Lou Romanens & Arkajyoti Bhattacharya & Stacey E. P. Joosten & Ana Moises Silva & Nuno Padrao & Max D. Welle, 2022. "MYC promotes immune-suppression in triple-negative breast cancer via inhibition of interferon signaling," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    12. Tomoko Yamamori Morita & Jie Yu & Yukie Kashima & Ryo Kamata & Gaku Yamamoto & Tatsunori Minamide & Chiaki Mashima & Miyuki Yoshiya & Yuta Sakae & Toyohiro Yamauchi & Yumi Hakozaki & Shun-ichiro Kagey, 2023. "CDC7 inhibition induces replication stress-mediated aneuploid cells with an inflammatory phenotype sensitizing tumors to immune checkpoint blockade," Nature Communications, Nature, vol. 14(1), pages 1-21, December.
    13. Yaping Huang & Changzheng Lu & Hanzhi Wang & Liya Gu & Yang-Xin Fu & Guo-Min Li, 2023. "DNAJA2 deficiency activates cGAS-STING pathway via the induction of aberrant mitosis and chromosome instability," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    14. Hervé Técher & Diyavarshini Gopaul & Jonathan Heuzé & Nail Bouzalmad & Baptiste Leray & Audrey Vernet & Clément Mettling & Jérôme Moreaux & Philippe Pasero & Yea-Lih Lin, 2024. "MRE11 and TREX1 control senescence by coordinating replication stress and interferon signaling," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    15. Daipayan Banerjee & Kurt Langberg & Salar Abbas & Eric Odermatt & Praveen Yerramothu & Martin Volaric & Matthew A. Reidenbach & Kathy J. Krentz & C. Dustin Rubinstein & David L. Brautigan & Tarek Abba, 2021. "A non-canonical, interferon-independent signaling activity of cGAMP triggers DNA damage response signaling," Nature Communications, Nature, vol. 12(1), pages 1-24, December.
    16. Kate M. MacDonald & Shirony Nicholson-Puthenveedu & Maha M. Tageldein & Sarika Khasnis & Cheryl H. Arrowsmith & Shane M. Harding, 2023. "Antecedent chromatin organization determines cGAS recruitment to ruptured micronuclei," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    17. Jimyung Seo & HyunSeok Kim & Kyoung Il Min & Changgon Kim & Yongsoo Kwon & Zhenlong Zheng & Yusung Kim & Hyung-Soon Park & Young Seok Ju & Mi Ryung Roh & Kee Yang Chung & Joon Kim, 2022. "Weight-bearing activity impairs nuclear membrane and genome integrity via YAP activation in plantar melanoma," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    18. Cuige Zhu & Mari Iwase & Ziqian Li & Faliang Wang & Annabel Quinet & Alessandro Vindigni & Jieya Shao, 2022. "Profilin-1 regulates DNA replication forks in a context-dependent fashion by interacting with SNF2H and BOD1L," Nature Communications, Nature, vol. 13(1), pages 1-19, December.

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