IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v548y2017i7668d10.1038_nature23449.html
   My bibliography  Save this article

cGAS surveillance of micronuclei links genome instability to innate immunity

Author

Listed:
  • Karen J. Mackenzie

    (MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, The University of Edinburgh)

  • Paula Carroll

    (MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, The University of Edinburgh)

  • Carol-Anne Martin

    (MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, The University of Edinburgh)

  • Olga Murina

    (MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, The University of Edinburgh)

  • Adeline Fluteau

    (MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, The University of Edinburgh)

  • Daniel J. Simpson

    (MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, The University of Edinburgh)

  • Nelly Olova

    (MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, The University of Edinburgh)

  • Hannah Sutcliffe

    (MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, The University of Edinburgh)

  • Jacqueline K. Rainger

    (MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, The University of Edinburgh)

  • Andrea Leitch

    (MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, The University of Edinburgh)

  • Ruby T. Osborn

    (MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, The University of Edinburgh)

  • Ann P. Wheeler

    (MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, The University of Edinburgh)

  • Marcin Nowotny

    (Laboratory of Protein Structure, International Institute of Molecular and Cell Biology)

  • Nick Gilbert

    (MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, The University of Edinburgh)

  • Tamir Chandra

    (MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, The University of Edinburgh)

  • Martin A. M. Reijns

    (MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, The University of Edinburgh)

  • Andrew P. Jackson

    (MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, The University of Edinburgh)

Abstract

The cytoplasmic DNA sensor cGAS detects DNA in ruptured micronuclei and activates an innate immune response.

Suggested Citation

  • Karen J. Mackenzie & Paula Carroll & Carol-Anne Martin & Olga Murina & Adeline Fluteau & Daniel J. Simpson & Nelly Olova & Hannah Sutcliffe & Jacqueline K. Rainger & Andrea Leitch & Ruby T. Osborn & A, 2017. "cGAS surveillance of micronuclei links genome instability to innate immunity," Nature, Nature, vol. 548(7668), pages 461-465, August.
    • Handle: RePEc:nat:nature:v:548:y:2017:i:7668:d:10.1038_nature23449
    DOI: 10.1038/nature23449
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature23449
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature23449?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Albert Stuart Reece & Gary Kenneth Hulse, 2022. "Cannabis- and Substance-Related Epidemiological Patterns of Chromosomal Congenital Anomalies in Europe: Geospatiotemporal and Causal Inferential Study," IJERPH, MDPI, vol. 19(18), pages 1-51, September.
    2. Qing Hu & Jose Espejo Valle-Inclán & Rashmi Dahiya & Alison Guyer & Alice Mazzagatti & Elizabeth G. Maurais & Justin L. Engel & Huiming Lu & Anthony J. Davis & Isidro Cortés-Ciriano & Peter Ly, 2024. "Non-homologous end joining shapes the genomic rearrangement landscape of chromothripsis from mitotic errors," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    3. Tanaz Sharifnia & Mathias J. Wawer & Amy Goodale & Yenarae Lee & Mariya Kazachkova & Joshua M. Dempster & Sandrine Muller & Joan Levy & Daniel M. Freed & Josh Sommer & Jérémie Kalfon & Francisca Vazqu, 2023. "Mapping the landscape of genetic dependencies in chordoma," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    4. Maritza Puray-Chavez & Jenna E. Eschbach & Ming Xia & Kyle M. LaPak & Qianzi Zhou & Ria Jasuja & Jiehong Pan & Jian Xu & Zixiang Zhou & Shawn Mohammed & Qibo Wang & Dana Q. Lawson & Sanja Djokic & Gao, 2024. "A basally active cGAS-STING pathway limits SARS-CoV-2 replication in a subset of ACE2 positive airway cell models," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    5. Xiujie Liang & Hongbo Liu & Hailong Hu & Eunji Ha & Jianfu Zhou & Amin Abedini & Andrea Sanchez-Navarro & Konstantin A. Klötzer & Katalin Susztak, 2024. "TET2 germline variants promote kidney disease by impairing DNA repair and activating cytosolic nucleotide sensors," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    6. Dario Zimmerli & Chiara S. Brambillasca & Francien Talens & Jinhyuk Bhin & Renske Linstra & Lou Romanens & Arkajyoti Bhattacharya & Stacey E. P. Joosten & Ana Moises Silva & Nuno Padrao & Max D. Welle, 2022. "MYC promotes immune-suppression in triple-negative breast cancer via inhibition of interferon signaling," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    7. Shengrui Feng & Sajid A. Marhon & Dustin J. Sokolowski & Alister D’Costa & Fraser Soares & Parinaz Mehdipour & Charles Ishak & Helen Loo Yau & Ilias Ettayebi & Parasvi S. Patel & Raymond Chen & Jiming, 2024. "Inhibiting EZH2 targets atypical teratoid rhabdoid tumor by triggering viral mimicry via both RNA and DNA sensing pathways," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    8. Tomoko Yamamori Morita & Jie Yu & Yukie Kashima & Ryo Kamata & Gaku Yamamoto & Tatsunori Minamide & Chiaki Mashima & Miyuki Yoshiya & Yuta Sakae & Toyohiro Yamauchi & Yumi Hakozaki & Shun-ichiro Kagey, 2023. "CDC7 inhibition induces replication stress-mediated aneuploid cells with an inflammatory phenotype sensitizing tumors to immune checkpoint blockade," Nature Communications, Nature, vol. 14(1), pages 1-21, December.
    9. Hervé Técher & Diyavarshini Gopaul & Jonathan Heuzé & Nail Bouzalmad & Baptiste Leray & Audrey Vernet & Clément Mettling & Jérôme Moreaux & Philippe Pasero & Yea-Lih Lin, 2024. "MRE11 and TREX1 control senescence by coordinating replication stress and interferon signaling," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    10. Yu-Hsuan Chen & Han-Hsiun Chen & Won-Jing Wang & Hsin-Yi Chen & Wei-Syun Huang & Chien-Han Kao & Sin-Rong Lee & Nai Yang Yeat & Ruei-Liang Yan & Shu-Jou Chan & Kuen-Phon Wu & Ruey-Hwa Chen, 2023. "TRABID inhibition activates cGAS/STING-mediated anti-tumor immunity through mitosis and autophagy dysregulation," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    11. Lina Wang & Siru Li & Kai Wang & Na Wang & Qiaoling Liu & Zhen Sun & Li Wang & Lulu Wang & Quentin Liu & Chengli Song & Caigang Liu & Qingkai Yang, 2022. "DNA mechanical flexibility controls DNA potential to activate cGAS-mediated immune surveillance," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    12. Christopher P. Wardlaw & John H. J. Petrini, 2022. "ISG15 conjugation to proteins on nascent DNA mitigates DNA replication stress," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    13. Ramona N. Moro & Uddipta Biswas & Suhas S. Kharat & Filip D. Duzanic & Prosun Das & Maria Stavrou & Maria C. Raso & Raimundo Freire & Arnab Ray Chaudhuri & Shyam K. Sharan & Lorenza Penengo, 2023. "Interferon restores replication fork stability and cell viability in BRCA-defective cells via ISG15," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    14. Francesca Mateo & Zhengcheng He & Lin Mei & Gorka Ruiz de Garibay & Carmen Herranz & Nadia García & Amanda Lorentzian & Alexandra Baiges & Eline Blommaert & Antonio Gómez & Oriol Mirallas & Anna Garri, 2022. "Modification of BRCA1-associated breast cancer risk by HMMR overexpression," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    15. M. J. Gutbrod & B. Roche & J. I. Steinberg & A. A. Lakhani & K. Chang & A. J. Schorn & R. A. Martienssen, 2022. "Dicer promotes genome stability via the bromodomain transcriptional co-activator BRD4," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    16. Yaping Huang & Changzheng Lu & Hanzhi Wang & Liya Gu & Yang-Xin Fu & Guo-Min Li, 2023. "DNAJA2 deficiency activates cGAS-STING pathway via the induction of aberrant mitosis and chromosome instability," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    17. Daipayan Banerjee & Kurt Langberg & Salar Abbas & Eric Odermatt & Praveen Yerramothu & Martin Volaric & Matthew A. Reidenbach & Kathy J. Krentz & C. Dustin Rubinstein & David L. Brautigan & Tarek Abba, 2021. "A non-canonical, interferon-independent signaling activity of cGAMP triggers DNA damage response signaling," Nature Communications, Nature, vol. 12(1), pages 1-24, December.
    18. Kate M. MacDonald & Shirony Nicholson-Puthenveedu & Maha M. Tageldein & Sarika Khasnis & Cheryl H. Arrowsmith & Shane M. Harding, 2023. "Antecedent chromatin organization determines cGAS recruitment to ruptured micronuclei," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    19. Jimyung Seo & HyunSeok Kim & Kyoung Il Min & Changgon Kim & Yongsoo Kwon & Zhenlong Zheng & Yusung Kim & Hyung-Soon Park & Young Seok Ju & Mi Ryung Roh & Kee Yang Chung & Joon Kim, 2022. "Weight-bearing activity impairs nuclear membrane and genome integrity via YAP activation in plantar melanoma," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    20. Cuige Zhu & Mari Iwase & Ziqian Li & Faliang Wang & Annabel Quinet & Alessandro Vindigni & Jieya Shao, 2022. "Profilin-1 regulates DNA replication forks in a context-dependent fashion by interacting with SNF2H and BOD1L," Nature Communications, Nature, vol. 13(1), pages 1-19, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:548:y:2017:i:7668:d:10.1038_nature23449. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.