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Genome-scale activation screen identifies a lncRNA locus regulating a gene neighbourhood

Author

Listed:
  • Julia Joung

    (MIT
    Broad Institute of MIT and Harvard
    McGovern Institute for Brain Research at MIT
    MIT)

  • Jesse M. Engreitz

    (Broad Institute of MIT and Harvard)

  • Silvana Konermann

    (Broad Institute of MIT and Harvard
    McGovern Institute for Brain Research at MIT
    MIT
    Salk Institute for Biological Studies)

  • Omar O. Abudayyeh

    (Broad Institute of MIT and Harvard
    McGovern Institute for Brain Research at MIT
    MIT
    MIT)

  • Vanessa K. Verdine

    (Broad Institute of MIT and Harvard
    McGovern Institute for Brain Research at MIT)

  • Francois Aguet

    (Broad Institute of MIT and Harvard)

  • Jonathan S. Gootenberg

    (Broad Institute of MIT and Harvard
    McGovern Institute for Brain Research at MIT
    MIT
    Harvard Medical School)

  • Neville E. Sanjana

    (Broad Institute of MIT and Harvard
    McGovern Institute for Brain Research at MIT
    MIT
    New York Genome Center)

  • Jason B. Wright

    (Broad Institute of MIT and Harvard
    McGovern Institute for Brain Research at MIT
    MIT)

  • Charles P. Fulco

    (Broad Institute of MIT and Harvard
    Harvard Medical School)

  • Yuen-Yi Tseng

    (Broad Institute of MIT and Harvard)

  • Charles H. Yoon

    (Brigham and Women’s Hospital)

  • Jesse S. Boehm

    (Broad Institute of MIT and Harvard)

  • Eric S. Lander

    (Broad Institute of MIT and Harvard
    Harvard Medical School
    MIT)

  • Feng Zhang

    (MIT
    Broad Institute of MIT and Harvard
    McGovern Institute for Brain Research at MIT
    MIT)

Abstract

Long noncoding RNAs are investigated using a CRISPR–Cas9 activation screen and shown to confer BRAF inhibitor resistance on melanoma cells through various local mechanisms.

Suggested Citation

  • Julia Joung & Jesse M. Engreitz & Silvana Konermann & Omar O. Abudayyeh & Vanessa K. Verdine & Francois Aguet & Jonathan S. Gootenberg & Neville E. Sanjana & Jason B. Wright & Charles P. Fulco & Yuen-, 2017. "Genome-scale activation screen identifies a lncRNA locus regulating a gene neighbourhood," Nature, Nature, vol. 548(7667), pages 343-346, August.
    • Handle: RePEc:nat:nature:v:548:y:2017:i:7667:d:10.1038_nature23451
    DOI: 10.1038/nature23451
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    Citations

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    Cited by:

    1. Teresa Maria Rosaria Noviello & Anna Maria Giacomo & Francesca Pia Caruso & Alessia Covre & Roberta Mortarini & Giovanni Scala & Maria Claudia Costa & Sandra Coral & Wolf H. Fridman & Catherine Sautès, 2023. "Guadecitabine plus ipilimumab in unresectable melanoma: five-year follow-up and integrated multi-omic analysis in the phase 1b NIBIT-M4 trial," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    2. Heike Chauvistré & Batool Shannan & Sheena M. Daignault-Mill & Robert J. Ju & Daniel Picard & Stefanie Egetemaier & Renáta Váraljai & Christine S. Gibhardt & Antonio Sechi & Farnusch Kaschani & Oliver, 2022. "Persister state-directed transitioning and vulnerability in melanoma," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    3. Anastasia Samarkina & Markus Kirolos Youssef & Paola Ostano & Soumitra Ghosh & Min Ma & Beatrice Tassone & Tatiana Proust & Giovanna Chiorino & Mitchell P. Levesque & Sandro Goruppi & Gian Paolo Dotto, 2023. "Androgen receptor is a determinant of melanoma targeted drug resistance," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    4. Florence M. Chardon & Troy A. McDiarmid & Nicholas F. Page & Riza M. Daza & Beth K. Martin & Silvia Domcke & Samuel G. Regalado & Jean-Benoît Lalanne & Diego Calderon & Xiaoyi Li & Lea M. Starita & St, 2024. "Multiplex, single-cell CRISPRa screening for cell type specific regulatory elements," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    5. Adam E. Hall & Sebastian Öther-Gee Pohl & Patrizia Cammareri & Stuart Aitken & Nicholas T. Younger & Michela Raponi & Caroline V. Billard & Alfonso Bolado Carrancio & Aslihan Bastem & Paz Freile & Fio, 2022. "RNA splicing is a key mediator of tumour cell plasticity and a therapeutic vulnerability in colorectal cancer," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    6. Xiaolong Cheng & Zexu Li & Ruocheng Shan & Zihan Li & Shengnan Wang & Wenchang Zhao & Han Zhang & Lumen Chao & Jian Peng & Teng Fei & Wei Li, 2023. "Modeling CRISPR-Cas13d on-target and off-target effects using machine learning approaches," Nature Communications, Nature, vol. 14(1), pages 1-14, December.

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