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m6A mRNA methylation controls T cell homeostasis by targeting the IL-7/STAT5/SOCS pathways

Author

Listed:
  • Hua-Bing Li

    (Yale University School of Medicine)

  • Jiyu Tong

    (Yale University School of Medicine
    The First Affiliated Hospital, Biomedical Translational Research Institute and Guangdong Province Key Laboratory of Molecular Immunology and Antibody Engineering, Jinan University)

  • Shu Zhu

    (Yale University School of Medicine)

  • Pedro J. Batista

    (Center for Dynamic Regulomes, Stanford University)

  • Erin E. Duffy

    (Yale University
    Chemical Biology Institute, Yale University)

  • Jun Zhao

    (Yale University School of Medicine
    Yale University School of Medicine)

  • Will Bailis

    (Yale University School of Medicine)

  • Guangchao Cao

    (Yale University School of Medicine
    The First Affiliated Hospital, Biomedical Translational Research Institute and Guangdong Province Key Laboratory of Molecular Immunology and Antibody Engineering, Jinan University)

  • Lina Kroehling

    (Yale University School of Medicine)

  • Yuanyuan Chen

    (Yale University School of Medicine
    Institute of Surgical Research, Daping Hospital, the Third Military Medical University)

  • Geng Wang

    (Yale University School of Medicine)

  • James P. Broughton

    (Center for Dynamic Regulomes, Stanford University)

  • Y. Grace Chen

    (Center for Dynamic Regulomes, Stanford University)

  • Yuval Kluger

    (Yale University School of Medicine)

  • Matthew D. Simon

    (Yale University
    Chemical Biology Institute, Yale University)

  • Howard Y. Chang

    (Center for Dynamic Regulomes, Stanford University)

  • Zhinan Yin

    (The First Affiliated Hospital, Biomedical Translational Research Institute and Guangdong Province Key Laboratory of Molecular Immunology and Antibody Engineering, Jinan University)

  • Richard A. Flavell

    (Yale University School of Medicine
    Howard Hughes Medical Institute)

Abstract

The authors assess the role of N6-methyladenosine in T cell development and function, and show that RNA methylation controls T cell homeostasis by regulating IL-7-mediated STAT5 activation.

Suggested Citation

  • Hua-Bing Li & Jiyu Tong & Shu Zhu & Pedro J. Batista & Erin E. Duffy & Jun Zhao & Will Bailis & Guangchao Cao & Lina Kroehling & Yuanyuan Chen & Geng Wang & James P. Broughton & Y. Grace Chen & Yuval , 2017. "m6A mRNA methylation controls T cell homeostasis by targeting the IL-7/STAT5/SOCS pathways," Nature, Nature, vol. 548(7667), pages 338-342, August.
    • Handle: RePEc:nat:nature:v:548:y:2017:i:7667:d:10.1038_nature23450
    DOI: 10.1038/nature23450
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    Cited by:

    1. Yan Xu & Zhuowei Zhou & Xinmei Kang & Lijie Pan & Chang Liu & Xiaoqi Liang & Jiajie Chu & Shuai Dong & Yanli Li & Qiuli Liu & Yuetong Sun & Shanshan Yu & Qi Zhang, 2022. "Mettl3-mediated mRNA m6A modification controls postnatal liver development by modulating the transcription factor Hnf4a," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    2. Cristina Leoni & Marian Bataclan & Taku Ito-Kureha & Vigo Heissmeyer & Silvia Monticelli, 2023. "The mRNA methyltransferase Mettl3 modulates cytokine mRNA stability and limits functional responses in mast cells," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    3. Xiao Han & Lijuan Liu & Saihua Huang & Wenfeng Xiao & Yajing Gao & Weitao Zhou & Caiyan Zhang & Hongmei Zheng & Lan Yang & Xueru Xie & Qiuyan Liang & Zikun Tu & Hongmiao Yu & Jinrong Fu & Libo Wang & , 2023. "RNA m6A methylation modulates airway inflammation in allergic asthma via PTX3-dependent macrophage homeostasis," Nature Communications, Nature, vol. 14(1), pages 1-20, December.

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