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Structural insights into ligand recognition by the lysophosphatidic acid receptor LPA6

Author

Listed:
  • Reiya Taniguchi

    (Graduate School of Science, The University of Tokyo
    Global Research Cluster, RIKEN)

  • Asuka Inoue

    (Laboratory of Molecular and Cellular Biochemistry, Graduate School of Pharmaceutical Sciences, Tohoku University
    Japan Science and Technology Agency (JST), Precursory Research for Embryonic Science and Technology (PRESTO))

  • Misa Sayama

    (Laboratory of Organic and Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo)

  • Akiharu Uwamizu

    (Laboratory of Molecular and Cellular Biochemistry, Graduate School of Pharmaceutical Sciences, Tohoku University)

  • Keitaro Yamashita

    (RIKEN SPring-8 Center)

  • Kunio Hirata

    (Japan Science and Technology Agency (JST), Precursory Research for Embryonic Science and Technology (PRESTO)
    RIKEN SPring-8 Center)

  • Masahito Yoshida

    (Laboratory of Heterocyclic Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku University)

  • Yoshiki Tanaka

    (Graduate School of Biological Sciences, Nara Institute of Science and Technology)

  • Hideaki E. Kato

    (Graduate School of Science, The University of Tokyo
    Global Research Cluster, RIKEN
    Stanford University School of Medicine)

  • Yoshiko Nakada-Nakura

    (Graduate School of Medicine, Kyoto University)

  • Yuko Otani

    (Laboratory of Organic and Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo)

  • Tomohiro Nishizawa

    (Graduate School of Science, The University of Tokyo
    Global Research Cluster, RIKEN
    Japan Science and Technology Agency (JST), Precursory Research for Embryonic Science and Technology (PRESTO))

  • Takayuki Doi

    (Laboratory of Heterocyclic Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku University)

  • Tomohiko Ohwada

    (Laboratory of Organic and Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo)

  • Ryuichiro Ishitani

    (Graduate School of Science, The University of Tokyo
    Global Research Cluster, RIKEN)

  • Junken Aoki

    (Laboratory of Molecular and Cellular Biochemistry, Graduate School of Pharmaceutical Sciences, Tohoku University
    Japan Agency for Medical Research and Development, Core Research for Evolutional Science and Technology (AMED-CREST))

  • Osamu Nureki

    (Graduate School of Science, The University of Tokyo
    Global Research Cluster, RIKEN)

Abstract

Determination of the crystal structure of the zebrafish LPA6 receptor shows that the lipid ligand binds to an unusual ligand-binding pocket in the receptor that is laterally accessible through the membrane.

Suggested Citation

  • Reiya Taniguchi & Asuka Inoue & Misa Sayama & Akiharu Uwamizu & Keitaro Yamashita & Kunio Hirata & Masahito Yoshida & Yoshiki Tanaka & Hideaki E. Kato & Yoshiko Nakada-Nakura & Yuko Otani & Tomohiro N, 2017. "Structural insights into ligand recognition by the lysophosphatidic acid receptor LPA6," Nature, Nature, vol. 548(7667), pages 356-360, August.
    • Handle: RePEc:nat:nature:v:548:y:2017:i:7667:d:10.1038_nature23448
    DOI: 10.1038/nature23448
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    Citations

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    Cited by:

    1. Jian He & Rui Gao & Mei Meng & Miao Yu & Chengrong Liu & Jingquan Li & Yizhi Song & Hui Wang, 2021. "Lysophosphatidic Acid Receptor 6 (LPAR6) Is a Potential Biomarker Associated with Lung Adenocarcinoma," IJERPH, MDPI, vol. 18(21), pages 1-25, October.
    2. Shota Suzuki & Kotaro Tanaka & Kouki Nishikawa & Hiroshi Suzuki & Atsunori Oshima & Yoshinori Fujiyoshi, 2023. "Structural basis of hydroxycarboxylic acid receptor signaling mechanisms through ligand binding," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    3. Hiroaki Akasaka & Tatsuki Tanaka & Fumiya K. Sano & Yuma Matsuzaki & Wataru Shihoya & Osamu Nureki, 2022. "Structure of the active Gi-coupled human lysophosphatidic acid receptor 1 complexed with a potent agonist," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    4. Jiale Liang & Asuka Inoue & Tatsuya Ikuta & Ruixue Xia & Na Wang & Kouki Kawakami & Zhenmei Xu & Yu Qian & Xinyan Zhu & Anqi Zhang & Changyou Guo & Zhiwei Huang & Yuanzheng He, 2023. "Structural basis of lysophosphatidylserine receptor GPR174 ligand recognition and activation," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    5. Tamaki Izume & Ryo Kawahara & Akiharu Uwamizu & Luying Chen & Shun Yaginuma & Jumpei Omi & Hiroki Kawana & Fengjue Hou & Fumiya K. Sano & Tatsuki Tanaka & Kazuhiro Kobayashi & Hiroyuki H. Okamoto & Yo, 2024. "Structural basis for lysophosphatidylserine recognition by GPR34," Nature Communications, Nature, vol. 15(1), pages 1-15, December.

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