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mRNA 3′ uridylation and poly(A) tail length sculpt the mammalian maternal transcriptome

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  • Marcos Morgan

    (MRC Centre for Regenerative Medicine, Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh
    European Molecular Biology Laboratory (EMBL), Mouse Biology Unit)

  • Christian Much

    (MRC Centre for Regenerative Medicine, Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh
    European Molecular Biology Laboratory (EMBL), Mouse Biology Unit)

  • Monica DiGiacomo

    (European Molecular Biology Laboratory (EMBL), Mouse Biology Unit)

  • Chiara Azzi

    (European Molecular Biology Laboratory (EMBL), Mouse Biology Unit)

  • Ivayla Ivanova

    (MRC Centre for Regenerative Medicine, Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh
    European Molecular Biology Laboratory (EMBL), Mouse Biology Unit)

  • Dimitrios M. Vitsios

    (European Molecular Biology Laboratory (EMBL), European Bioinformatics Institute (EBI), Wellcome Genome Campus)

  • Jelena Pistolic

    (European Molecular Biology Laboratory (EMBL), Genomics Core Facility)

  • Paul Collier

    (European Molecular Biology Laboratory (EMBL), Genomics Core Facility)

  • Pedro N. Moreira

    (MRC Centre for Regenerative Medicine, Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh
    European Molecular Biology Laboratory (EMBL), Mouse Biology Unit)

  • Vladimir Benes

    (European Molecular Biology Laboratory (EMBL), Genomics Core Facility)

  • Anton J. Enright

    (European Molecular Biology Laboratory (EMBL), European Bioinformatics Institute (EBI), Wellcome Genome Campus)

  • Dónal O’Carroll

    (MRC Centre for Regenerative Medicine, Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh
    European Molecular Biology Laboratory (EMBL), Mouse Biology Unit)

Abstract

TUT4 and TUT7 mediate 3′ uridylation of mRNA transcripts, preferentially those with short poly(A) tails; in the absence of TUT4 and TUT7, oocytes cannot mature and female mice are infertile.

Suggested Citation

  • Marcos Morgan & Christian Much & Monica DiGiacomo & Chiara Azzi & Ivayla Ivanova & Dimitrios M. Vitsios & Jelena Pistolic & Paul Collier & Pedro N. Moreira & Vladimir Benes & Anton J. Enright & Dónal , 2017. "mRNA 3′ uridylation and poly(A) tail length sculpt the mammalian maternal transcriptome," Nature, Nature, vol. 548(7667), pages 347-351, August.
    • Handle: RePEc:nat:nature:v:548:y:2017:i:7667:d:10.1038_nature23318
    DOI: 10.1038/nature23318
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    Cited by:

    1. Seisuke Yamashita & Kozo Tomita, 2023. "Mechanism of U6 snRNA oligouridylation by human TUT1," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    2. Xue Jiang & Yu Cheng & Yuzhang Zhu & Caoling Xu & Qiaodan Li & Xuemei Xing & Wenqing Li & Jiaqi Zou & Lan Meng & Muhammad Azhar & Yuzhu Cao & Xianhong Tong & Weibing Qin & Xiaoli Zhu & Jianqiang Bao, 2023. "Maternal NAT10 orchestrates oocyte meiotic cell-cycle progression and maturation in mice," Nature Communications, Nature, vol. 14(1), pages 1-23, December.

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