IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v548y2017i7667d10.1038_nature23318.html
   My bibliography  Save this article

mRNA 3′ uridylation and poly(A) tail length sculpt the mammalian maternal transcriptome

Author

Listed:
  • Marcos Morgan

    (MRC Centre for Regenerative Medicine, Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh
    European Molecular Biology Laboratory (EMBL), Mouse Biology Unit)

  • Christian Much

    (MRC Centre for Regenerative Medicine, Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh
    European Molecular Biology Laboratory (EMBL), Mouse Biology Unit)

  • Monica DiGiacomo

    (European Molecular Biology Laboratory (EMBL), Mouse Biology Unit)

  • Chiara Azzi

    (European Molecular Biology Laboratory (EMBL), Mouse Biology Unit)

  • Ivayla Ivanova

    (MRC Centre for Regenerative Medicine, Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh
    European Molecular Biology Laboratory (EMBL), Mouse Biology Unit)

  • Dimitrios M. Vitsios

    (European Molecular Biology Laboratory (EMBL), European Bioinformatics Institute (EBI), Wellcome Genome Campus)

  • Jelena Pistolic

    (European Molecular Biology Laboratory (EMBL), Genomics Core Facility)

  • Paul Collier

    (European Molecular Biology Laboratory (EMBL), Genomics Core Facility)

  • Pedro N. Moreira

    (MRC Centre for Regenerative Medicine, Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh
    European Molecular Biology Laboratory (EMBL), Mouse Biology Unit)

  • Vladimir Benes

    (European Molecular Biology Laboratory (EMBL), Genomics Core Facility)

  • Anton J. Enright

    (European Molecular Biology Laboratory (EMBL), European Bioinformatics Institute (EBI), Wellcome Genome Campus)

  • Dónal O’Carroll

    (MRC Centre for Regenerative Medicine, Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh
    European Molecular Biology Laboratory (EMBL), Mouse Biology Unit)

Abstract

TUT4 and TUT7 mediate 3′ uridylation of mRNA transcripts, preferentially those with short poly(A) tails; in the absence of TUT4 and TUT7, oocytes cannot mature and female mice are infertile.

Suggested Citation

  • Marcos Morgan & Christian Much & Monica DiGiacomo & Chiara Azzi & Ivayla Ivanova & Dimitrios M. Vitsios & Jelena Pistolic & Paul Collier & Pedro N. Moreira & Vladimir Benes & Anton J. Enright & Dónal , 2017. "mRNA 3′ uridylation and poly(A) tail length sculpt the mammalian maternal transcriptome," Nature, Nature, vol. 548(7667), pages 347-351, August.
  • Handle: RePEc:nat:nature:v:548:y:2017:i:7667:d:10.1038_nature23318
    DOI: 10.1038/nature23318
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature23318
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.

    File URL: https://libkey.io/10.1038/nature23318?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Xue Jiang & Yu Cheng & Yuzhang Zhu & Caoling Xu & Qiaodan Li & Xuemei Xing & Wenqing Li & Jiaqi Zou & Lan Meng & Muhammad Azhar & Yuzhu Cao & Xianhong Tong & Weibing Qin & Xiaoli Zhu & Jianqiang Bao, 2023. "Maternal NAT10 orchestrates oocyte meiotic cell-cycle progression and maturation in mice," Nature Communications, Nature, vol. 14(1), pages 1-23, December.
    2. Seisuke Yamashita & Kozo Tomita, 2023. "Mechanism of U6 snRNA oligouridylation by human TUT1," Nature Communications, Nature, vol. 14(1), pages 1-10, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:548:y:2017:i:7667:d:10.1038_nature23318. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.