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Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK

Author

Listed:
  • Chen-Song Zhang

    (State Key Laboratory for Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University)

  • Simon A. Hawley

    (College of Life Sciences, University of Dundee)

  • Yue Zong

    (State Key Laboratory for Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University)

  • Mengqi Li

    (State Key Laboratory for Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University)

  • Zhichao Wang

    (Scientific Research Center for Translational Medicine, Dalian Institute of Chemical Physics, Chinese Academy of Sciences
    Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Alexander Gray

    (College of Life Sciences, University of Dundee)

  • Teng Ma

    (State Key Laboratory for Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University)

  • Jiwen Cui

    (State Key Laboratory for Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University)

  • Jin-Wei Feng

    (State Key Laboratory for Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University)

  • Mingjiang Zhu

    (Key Laboratory of Food Safety Research, Institute for Nutritional Sciences (INS), Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS))

  • Yu-Qing Wu

    (State Key Laboratory for Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University)

  • Terytty Yang Li

    (State Key Laboratory for Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University)

  • Zhiyun Ye

    (State Key Laboratory for Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University)

  • Shu-Yong Lin

    (State Key Laboratory for Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University)

  • Huiyong Yin

    (Key Laboratory of Food Safety Research, Institute for Nutritional Sciences (INS), Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS))

  • Hai-Long Piao

    (Scientific Research Center for Translational Medicine, Dalian Institute of Chemical Physics, Chinese Academy of Sciences)

  • D. Grahame Hardie

    (College of Life Sciences, University of Dundee)

  • Sheng-Cai Lin

    (State Key Laboratory for Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University)

Abstract

Glucose starvation activates AMPK via an AMP/ADP-independent mechanism that involves fructose-1,6-bisphosphate and aldolase.

Suggested Citation

  • Chen-Song Zhang & Simon A. Hawley & Yue Zong & Mengqi Li & Zhichao Wang & Alexander Gray & Teng Ma & Jiwen Cui & Jin-Wei Feng & Mingjiang Zhu & Yu-Qing Wu & Terytty Yang Li & Zhiyun Ye & Shu-Yong Lin , 2017. "Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK," Nature, Nature, vol. 548(7665), pages 112-116, August.
    • Handle: RePEc:nat:nature:v:548:y:2017:i:7665:d:10.1038_nature23275
    DOI: 10.1038/nature23275
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    Citations

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    Cited by:

    1. Javier Moral-Sanz & Sophronia A. Lewis & Sandy MacMillan & Marco Meloni & Heather McClafferty & Benoit Viollet & Marc Foretz & Jorge del-Pozo & A. Mark Evans, 2022. "AMPK deficiency in smooth muscles causes persistent pulmonary hypertension of the new-born and premature death," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    2. Danielle L. Schmitt & Stephanie D. Curtis & Anne C. Lyons & Jin-fan Zhang & Mingyuan Chen & Catherine Y. He & Sohum Mehta & Reuben J. Shaw & Jin Zhang, 2022. "Spatial regulation of AMPK signaling revealed by a sensitive kinase activity reporter," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    3. Yingfeng Tu & Qin Yang & Min Tang & Li Gao & Yuanhao Wang & Jiuqiang Wang & Zhe Liu & Xiaoyu Li & Lejiao Mao & Rui zhen Jia & Yuan Wang & Tie-shan Tang & Pinglong Xu & Yan Liu & Lunzhi Dai & Da Jia, 2024. "TBC1D23 mediates Golgi-specific LKB1 signaling," Nature Communications, Nature, vol. 15(1), pages 1-21, December.
    4. Elizabeth Haythorne & Matthew Lloyd & John Walsby-Tickle & Andrei I. Tarasov & Jonas Sandbrink & Idoia Portillo & Raul Terron Exposito & Gregor Sachse & Malgorzata Cyranka & Maria Rohm & Patrik Rorsma, 2022. "Altered glycolysis triggers impaired mitochondrial metabolism and mTORC1 activation in diabetic β-cells," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    5. Yaqiong Li & Zhipeng Niu & Jichao Yang & Xuke Yang & Yukun Chen & Yingying Li & Xiaohan Liang & Jingwen Zhang & Fuqiang Fan & Ping Wu & Chao Peng & Bang Shen, 2023. "Rapid metabolic reprogramming mediated by the AMP-activated protein kinase during the lytic cycle of Toxoplasma gondii," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    6. Zhenzhen Zi & Zhuzhen Zhang & Qiang Feng & Chiho Kim & Xu-Dong Wang & Philipp E. Scherer & Jinming Gao & Beth Levine & Yonghao Yu, 2022. "Quantitative phosphoproteomic analyses identify STK11IP as a lysosome-specific substrate of mTORC1 that regulates lysosomal acidification," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    7. Yanling Zhang & Yafei Cao & Xia Wu & Zhenghui Chen & Bowen Chen & Anhui Wang & Yanshen Guo & Wei Chen & Ruolan Xue & Zihua Liu & Yuanpei Li & Tian Li & Ruiqin Cheng & Ning Zhou & Jing Li & Yuan Liu & , 2024. "Thermal proteome profiling reveals fructose-1,6-bisphosphate as a phosphate donor to activate phosphoglycerate mutase 1," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    8. Kibum Kim & Hee Chan Yoo & Byung Gyu Kim & Sulhee Kim & Yulseung Sung & Ina Yoon & Ya Chun Yu & Seung Joon Park & Jong Hyun Kim & Kyungjae Myung & Kwang Yeon Hwang & Sunghoon Kim & Jung Min Han, 2022. "O-GlcNAc modification of leucyl-tRNA synthetase 1 integrates leucine and glucose availability to regulate mTORC1 and the metabolic fate of leucine," Nature Communications, Nature, vol. 13(1), pages 1-19, December.

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