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Unique roles for histone H3K9me states in RNAi and heritable silencing of transcription

Author

Listed:
  • Gloria Jih

    (Harvard Medical School
    Howard Hughes Medical Institute, Harvard Medical School)

  • Nahid Iglesias

    (Harvard Medical School
    Howard Hughes Medical Institute, Harvard Medical School)

  • Mark A. Currie

    (Harvard Medical School
    Howard Hughes Medical Institute, Harvard Medical School)

  • Natarajan V. Bhanu

    (Epigenetics Program, Perelman School of Medicine, University of Pennsylvania)

  • Joao A. Paulo

    (Harvard Medical School)

  • Steven P. Gygi

    (Harvard Medical School)

  • Benjamin A. Garcia

    (Epigenetics Program, Perelman School of Medicine, University of Pennsylvania)

  • Danesh Moazed

    (Harvard Medical School
    Howard Hughes Medical Institute, Harvard Medical School)

Abstract

Heterochromatin formation involves histone H3 methylation, with H3K9me2 defining a distinct heterochromatin state that is transcriptionally permissive and can couple with RNAi, and the transition to non-permissive H3K9me3 required for the epigenetic heritability of heterochromatin.

Suggested Citation

  • Gloria Jih & Nahid Iglesias & Mark A. Currie & Natarajan V. Bhanu & Joao A. Paulo & Steven P. Gygi & Benjamin A. Garcia & Danesh Moazed, 2017. "Unique roles for histone H3K9me states in RNAi and heritable silencing of transcription," Nature, Nature, vol. 547(7664), pages 463-467, July.
    • Handle: RePEc:nat:nature:v:547:y:2017:i:7664:d:10.1038_nature23267
    DOI: 10.1038/nature23267
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    Cited by:

    1. Hyun-Soo Kim & Benjamin Roche & Sonali Bhattacharjee & Leila Todeschini & An-Yun Chang & Christopher Hammell & André Verdel & Robert A. Martienssen, 2024. "Clr4SUV39H1 ubiquitination and non-coding RNA mediate transcriptional silencing of heterochromatin via Swi6 phase separation," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    2. Fernando Rodriguez & Irina A. Yushenova & Daniel DiCorpo & Irina R. Arkhipova, 2022. "Bacterial N4-methylcytosine as an epigenetic mark in eukaryotic DNA," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    3. Caojie Liu & Qiuchan Xiong & Qiwen Li & Weimin Lin & Shuang Jiang & Danting Zhang & Yuan Wang & Xiaobo Duan & Ping Gong & Ning Kang, 2022. "CHD7 regulates bone-fat balance by suppressing PPAR-γ signaling," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    4. Kate M. MacDonald & Shirony Nicholson-Puthenveedu & Maha M. Tageldein & Sarika Khasnis & Cheryl H. Arrowsmith & Shane M. Harding, 2023. "Antecedent chromatin organization determines cGAS recruitment to ruptured micronuclei," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

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