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Transcription elongation factors represent in vivo cancer dependencies in glioblastoma

Author

Listed:
  • Tyler E. Miller

    (Lerner Research Institute, Cleveland Clinic
    Cleveland Clinic Lerner College of Medicine, Case Western Reserve University
    Case Western Reserve University School of Medicine
    Case Western Reserve University School of Medicine)

  • Brian B. Liau

    (Harvard Medical School
    Epigenomics Program, Broad Institute
    Massachusetts General Hospital)

  • Lisa C. Wallace

    (Lerner Research Institute, Cleveland Clinic)

  • Andrew R. Morton

    (Lerner Research Institute, Cleveland Clinic
    Case Western Reserve University School of Medicine)

  • Qi Xie

    (Lerner Research Institute, Cleveland Clinic)

  • Deobrat Dixit

    (Lerner Research Institute, Cleveland Clinic)

  • Daniel C. Factor

    (Case Western Reserve University School of Medicine)

  • Leo J. Y. Kim

    (Lerner Research Institute, Cleveland Clinic
    Cleveland Clinic Lerner College of Medicine, Case Western Reserve University
    Case Western Reserve University School of Medicine)

  • James J. Morrow

    (Case Western Reserve University School of Medicine
    Case Western Reserve University School of Medicine)

  • Qiulian Wu

    (Lerner Research Institute, Cleveland Clinic)

  • Stephen C. Mack

    (Lerner Research Institute, Cleveland Clinic
    Cleveland Clinic Lerner College of Medicine, Case Western Reserve University)

  • Christopher G. Hubert

    (Lerner Research Institute, Cleveland Clinic
    Cleveland Clinic Lerner College of Medicine, Case Western Reserve University)

  • Shawn M. Gillespie

    (Harvard Medical School
    Epigenomics Program, Broad Institute
    Massachusetts General Hospital)

  • William A. Flavahan

    (Lerner Research Institute, Cleveland Clinic
    Cleveland Clinic Lerner College of Medicine, Case Western Reserve University)

  • Thomas Hoffmann

    (Research Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC))

  • Rohit Thummalapalli

    (Harvard Medical School
    Epigenomics Program, Broad Institute
    Massachusetts General Hospital)

  • Michael T. Hemann

    (The Koch Institute for Integrative Cancer Research at MIT, Massachusetts Institute of Technology)

  • Patrick J. Paddison

    (Fred Hutchinson Cancer Research Center)

  • Craig M. Horbinski

    (Feinberg School of Medicine, Northwestern University
    Feinberg School of Medicine, Northwestern University)

  • Johannes Zuber

    (Research Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC))

  • Peter C. Scacheri

    (Case Western Reserve University School of Medicine)

  • Bradley E. Bernstein

    (Harvard Medical School
    Epigenomics Program, Broad Institute
    Massachusetts General Hospital)

  • Paul J. Tesar

    (Case Western Reserve University School of Medicine)

  • Jeremy N. Rich

    (Lerner Research Institute, Cleveland Clinic
    Cleveland Clinic Lerner College of Medicine, Case Western Reserve University
    University of California at San Diego)

Abstract

An in vivo RNA interference screening strategy in glioblastoma enabled the identification of a host of epigenetic targets required for glioblastoma cell survival that were not identified by parallel standard screening in cell culture, including the transcription pause–release factor JMJD6, and could be a powerful tool to uncover new therapeutic targets in cancer.

Suggested Citation

  • Tyler E. Miller & Brian B. Liau & Lisa C. Wallace & Andrew R. Morton & Qi Xie & Deobrat Dixit & Daniel C. Factor & Leo J. Y. Kim & James J. Morrow & Qiulian Wu & Stephen C. Mack & Christopher G. Huber, 2017. "Transcription elongation factors represent in vivo cancer dependencies in glioblastoma," Nature, Nature, vol. 547(7663), pages 355-359, July.
    • Handle: RePEc:nat:nature:v:547:y:2017:i:7663:d:10.1038_nature23000
    DOI: 10.1038/nature23000
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    Cited by:

    1. Faye M. Walker & Lays Martin Sobral & Etienne Danis & Bridget Sanford & Sahiti Donthula & Ilango Balakrishnan & Dong Wang & Angela Pierce & Sana D. Karam & Soudabeh Kargar & Natalie J. Serkova & Nicho, 2024. "Rapid P-TEFb-dependent transcriptional reorganization underpins the glioma adaptive response to radiotherapy," Nature Communications, Nature, vol. 15(1), pages 1-21, December.
    2. Jieqiong Zhang & Zhenhua Hu & Hwa Hwa Chung & Yun Tian & Kah Weng Lau & Zheng Ser & Yan Ting Lim & Radoslaw M. Sobota & Hwei Fen Leong & Benjamin Jieming Chen & Clarisse Jingyi Yeo & Shawn Ying Xuan T, 2023. "Dependency of NELF-E-SLUG-KAT2B epigenetic axis in breast cancer carcinogenesis," Nature Communications, Nature, vol. 14(1), pages 1-21, December.

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