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T cells from patients with Parkinson’s disease recognize α-synuclein peptides

Author

Listed:
  • David Sulzer

    (Columbia University, New York State Psychiatric Institute
    Columbia University
    Columbia University)

  • Roy N. Alcalay

    (Columbia University)

  • Francesca Garretti

    (Columbia University, New York State Psychiatric Institute)

  • Lucien Cote

    (Columbia University)

  • Ellen Kanter

    (Columbia University, New York State Psychiatric Institute)

  • Julian Agin-Liebes

    (Columbia University, New York State Psychiatric Institute)

  • Christopher Liong

    (Columbia University)

  • Curtis McMurtrey

    (University of Oklahoma)

  • William H. Hildebrand

    (University of Oklahoma)

  • Xiaobo Mao

    (Neuroregeneration and Stem Cell Program, Johns Hopkins University School of Medicine
    Adrienne Helis Malvin Medical Research Foundation, New Orleans)

  • Valina L. Dawson

    (Neuroregeneration and Stem Cell Program, Johns Hopkins University School of Medicine
    Adrienne Helis Malvin Medical Research Foundation, New Orleans
    Johns Hopkins University School of Medicine
    Johns Hopkins University School of Medicine)

  • Ted M. Dawson

    (Neuroregeneration and Stem Cell Program, Johns Hopkins University School of Medicine
    Adrienne Helis Malvin Medical Research Foundation, New Orleans
    Johns Hopkins University School of Medicine
    Johns Hopkins University School of Medicine)

  • Carla Oseroff

    (La Jolla Institute for Allergy and Immunology)

  • John Pham

    (La Jolla Institute for Allergy and Immunology)

  • John Sidney

    (La Jolla Institute for Allergy and Immunology)

  • Myles B. Dillon

    (La Jolla Institute for Allergy and Immunology)

  • Chelsea Carpenter

    (La Jolla Institute for Allergy and Immunology)

  • Daniela Weiskopf

    (La Jolla Institute for Allergy and Immunology)

  • Elizabeth Phillips

    (Columbia University, New York State Psychiatric Institute
    Columbia University
    Institute for Immunology and Infectious Diseases, Murdoch University)

  • Simon Mallal

    (Columbia University, New York State Psychiatric Institute
    Columbia University
    Institute for Immunology and Infectious Diseases, Murdoch University)

  • Bjoern Peters

    (La Jolla Institute for Allergy and Immunology)

  • April Frazier

    (La Jolla Institute for Allergy and Immunology)

  • Cecilia S. Lindestam Arlehamn

    (La Jolla Institute for Allergy and Immunology)

  • Alessandro Sette

    (La Jolla Institute for Allergy and Immunology)

Abstract

Epitopes derived from two regions of α-synuclein elicit immune responses in patients with Parkinson’s disease, involving IL-5-secreting CD4+ T cells, as well as IFNγ-secreting CD8+ cytotoxic T cells.

Suggested Citation

  • David Sulzer & Roy N. Alcalay & Francesca Garretti & Lucien Cote & Ellen Kanter & Julian Agin-Liebes & Christopher Liong & Curtis McMurtrey & William H. Hildebrand & Xiaobo Mao & Valina L. Dawson & Te, 2017. "T cells from patients with Parkinson’s disease recognize α-synuclein peptides," Nature, Nature, vol. 546(7660), pages 656-661, June.
    • Handle: RePEc:nat:nature:v:546:y:2017:i:7660:d:10.1038_nature22815
    DOI: 10.1038/nature22815
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    Cited by:

    1. Simone Bido & Sharon Muggeo & Luca Massimino & Matteo Jacopo Marzi & Serena Gea Giannelli & Elena Melacini & Melania Nannoni & Diana Gambarè & Edoardo Bellini & Gabriele Ordazzo & Greta Rossi & Camill, 2021. "Microglia-specific overexpression of α-synuclein leads to severe dopaminergic neurodegeneration by phagocytic exhaustion and oxidative toxicity," Nature Communications, Nature, vol. 12(1), pages 1-15, December.
    2. Christophe M. Capelle & Séverine Ciré & Fanny Hedin & Maxime Hansen & Lukas Pavelka & Kamil Grzyb & Dimitrios Kyriakis & Oliver Hunewald & Maria Konstantinou & Dominique Revets & Vera Tslaf & Tainá M., 2023. "Early-to-mid stage idiopathic Parkinson’s disease shows enhanced cytotoxicity and differentiation in CD8 T-cells in females," Nature Communications, Nature, vol. 14(1), pages 1-21, December.
    3. A. M. Schonhoff & D. A. Figge & G. P. Williams & A. Jurkuvenaite & N. J. Gallups & G. M. Childers & J. M. Webster & D. G. Standaert & J. E. Goldman & A. S. Harms, 2023. "Border-associated macrophages mediate the neuroinflammatory response in an alpha-synuclein model of Parkinson disease," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    4. Jiao Jiao Liu & Xi He & Jie Liu & Jing Shan Shi, 2020. "Sexual Steroids and their Receptors Affect Microglia-Mediated Neuroinflammation in Neurodegenerative Diseases," Biomedical Journal of Scientific & Technical Research, Biomedical Research Network+, LLC, vol. 25(2), pages 18886-18896, January.

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