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Selective depletion of uropathogenic E. coli from the gut by a FimH antagonist

Author

Listed:
  • Caitlin N. Spaulding

    (Washington University in St Louis
    Center for Women’s Infectious Disease Research (CWIDR), Washington University in St Louis)

  • Roger D. Klein

    (Washington University in St Louis
    Center for Women’s Infectious Disease Research (CWIDR), Washington University in St Louis)

  • Ségolène Ruer

    (Structural and Molecular Microbiology, VIB Center for Structural Biology
    Structural Biology Brussels, Vrije Universiteit Brussel)

  • Andrew L. Kau

    (Center for Women’s Infectious Disease Research (CWIDR), Washington University in St Louis
    Washington University in St Louis)

  • Henry L. Schreiber

    (Washington University in St Louis
    Center for Women’s Infectious Disease Research (CWIDR), Washington University in St Louis
    The Broad Institute of MIT and Harvard)

  • Zachary T. Cusumano

    (Washington University in St Louis
    Center for Women’s Infectious Disease Research (CWIDR), Washington University in St Louis)

  • Karen W. Dodson

    (Washington University in St Louis
    Center for Women’s Infectious Disease Research (CWIDR), Washington University in St Louis)

  • Jerome S. Pinkner

    (Washington University in St Louis
    Center for Women’s Infectious Disease Research (CWIDR), Washington University in St Louis)

  • Daved H. Fremont

    (Washington University in St Louis
    Washington University in St Louis
    Washington University in St Louis)

  • James W. Janetka

    (Center for Women’s Infectious Disease Research (CWIDR), Washington University in St Louis
    Washington University in St Louis)

  • Han Remaut

    (Structural and Molecular Microbiology, VIB Center for Structural Biology
    Structural Biology Brussels, Vrije Universiteit Brussel)

  • Jeffrey I. Gordon

    (Center for Genome Sciences and Systems Biology, Washington University in St Louis
    Center for Gut Microbiome and Nutrition Research, Washington University in St Louis)

  • Scott J. Hultgren

    (Washington University in St Louis
    Center for Women’s Infectious Disease Research (CWIDR), Washington University in St Louis)

Abstract

Both F17-like and type 1 pili promote intestinal colonization in mouse colonic crypts, and the high-affinity mannoside M4284 reduces intestinal colonization of uropathogenic Escherichia coli while simultaneously treating urinary tract infections without disrupting the composition of the gut microbiota.

Suggested Citation

  • Caitlin N. Spaulding & Roger D. Klein & Ségolène Ruer & Andrew L. Kau & Henry L. Schreiber & Zachary T. Cusumano & Karen W. Dodson & Jerome S. Pinkner & Daved H. Fremont & James W. Janetka & Han Remau, 2017. "Selective depletion of uropathogenic E. coli from the gut by a FimH antagonist," Nature, Nature, vol. 546(7659), pages 528-532, June.
    • Handle: RePEc:nat:nature:v:546:y:2017:i:7659:d:10.1038_nature22972
    DOI: 10.1038/nature22972
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    Cited by:

    1. Paul A Roberts & Ryan M Huebinger & Emma Keen & Anne-Marie Krachler & Sara Jabbari, 2018. "Predictive modelling of a novel anti-adhesion therapy to combat bacterial colonisation of burn wounds," PLOS Computational Biology, Public Library of Science, vol. 14(5), pages 1-28, May.
    2. Serena Petracchini & Daniel Hamaoui & Anne Doye & Atef Asnacios & Florian Fage & Elisa Vitiello & Martial Balland & Sebastien Janel & Frank Lafont & Mukund Gupta & Benoit Ladoux & Jerôme Gilleron & Te, 2022. "Optineurin links Hace1-dependent Rac ubiquitylation to integrin-mediated mechanotransduction to control bacterial invasion and cell division," Nature Communications, Nature, vol. 13(1), pages 1-22, December.
    3. April Schweinhart & Janine Austin Clayton, 2018. "Reversing the Trends toward Shorter Lives and Poorer Health for U.S. Women: A Call for Innovative Interdisciplinary Research," IJERPH, MDPI, vol. 15(9), pages 1-14, August.
    4. Mark G. Young & Timothy J. Straub & Colin J. Worby & Hayden C. Metsky & Andreas Gnirke & Ryan A. Bronson & Lucas R. van Dijk & Christopher A. Desjardins & Christian Matranga & James Qu & Jesús Bazan V, 2024. "Distinct Escherichia coli transcriptional profiles in the guts of recurrent UTI sufferers revealed by pangenome hybrid selection," Nature Communications, Nature, vol. 15(1), pages 1-15, December.

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