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Identification of preoptic sleep neurons using retrograde labelling and gene profiling

Author

Listed:
  • Shinjae Chung

    (Helen Wills Neuroscience Institute, Howard Hughes Medical Institute, University of California)

  • Franz Weber

    (Helen Wills Neuroscience Institute, Howard Hughes Medical Institute, University of California)

  • Peng Zhong

    (Helen Wills Neuroscience Institute, Howard Hughes Medical Institute, University of California)

  • Chan Lek Tan

    (University of California, San Francisco)

  • Thuc Nghi Nguyen

    (Allen Institute for Brain Science)

  • Kevin T. Beier

    (Howard Hughes Medical Institute, Stanford University)

  • Nikolai Hörmann

    (Helen Wills Neuroscience Institute, Howard Hughes Medical Institute, University of California)

  • Wei-Cheng Chang

    (Helen Wills Neuroscience Institute, Howard Hughes Medical Institute, University of California)

  • Zhe Zhang

    (Helen Wills Neuroscience Institute, Howard Hughes Medical Institute, University of California)

  • Johnny Phong Do

    (Helen Wills Neuroscience Institute, Howard Hughes Medical Institute, University of California)

  • Shenqin Yao

    (Allen Institute for Brain Science)

  • Michael J. Krashes

    (Diabetes, Endocrinology and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health
    National Institute on Drug Abuse, National Institutes of Health)

  • Bosiljka Tasic

    (Allen Institute for Brain Science)

  • Ali Cetin

    (Allen Institute for Brain Science)

  • Hongkui Zeng

    (Allen Institute for Brain Science)

  • Zachary A. Knight

    (University of California, San Francisco)

  • Liqun Luo

    (Howard Hughes Medical Institute, Stanford University)

  • Yang Dan

    (Helen Wills Neuroscience Institute, Howard Hughes Medical Institute, University of California)

Abstract

Identification of sleep-active and sleep-promoting neurons in the preoptic area of the hypothalamus using neural projection tracing tools to target this population among a group of intermingled neurons, all with various functions.

Suggested Citation

  • Shinjae Chung & Franz Weber & Peng Zhong & Chan Lek Tan & Thuc Nghi Nguyen & Kevin T. Beier & Nikolai Hörmann & Wei-Cheng Chang & Zhe Zhang & Johnny Phong Do & Shenqin Yao & Michael J. Krashes & Bosil, 2017. "Identification of preoptic sleep neurons using retrograde labelling and gene profiling," Nature, Nature, vol. 545(7655), pages 477-481, May.
    • Handle: RePEc:nat:nature:v:545:y:2017:i:7655:d:10.1038_nature22350
    DOI: 10.1038/nature22350
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    Citations

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    Cited by:

    1. Roberto Luca & Stefano Nardone & Kevin P. Grace & Anne Venner & Michela Cristofolini & Sathyajit S. Bandaru & Lauren T. Sohn & Dong Kong & Takatoshi Mochizuki & Bianca Viberti & Lin Zhu & Antonino Zit, 2022. "Orexin neurons inhibit sleep to promote arousal," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    2. Can Tao & Guang-Wei Zhang & Wen-Jian Sun & Junxiang J. Huang & Li I. Zhang & Huizhong Whit Tao, 2024. "Excitation-inhibition imbalance in medial preoptic area circuits underlies chronic stress-induced depression-like states," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    3. Ruina Wang & Lei Xiao & Jianbo Pan & Guangsen Bao & Yunmei Zhu & Di Zhu & Jun Wang & Chengfeng Pei & Qinfeng Ma & Xian Fu & Ziruoyu Wang & Mengdi Zhu & Guoxiang Wang & Ling Gong & Qiuping Tong & Min J, 2023. "Natural product P57 induces hypothermia through targeting pyridoxal kinase," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    4. Shuancheng Ren & Cai Zhang & Faguo Yue & Jinxiang Tang & Wei Zhang & Yue Zheng & Yuanyuan Fang & Na Wang & Zhenbo Song & Zehui Zhang & Xiaolong Zhang & Han Qin & Yaling Wang & Jianxia Xia & Chenggang , 2024. "A midbrain GABAergic circuit constrains wakefulness in a mouse model of stress," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    5. Sasa Teng & Fenghua Zhen & Li Wang & Jose Canovas Schalchli & Jane Simko & Xinyue Chen & Hao Jin & Christopher D. Makinson & Yueqing Peng, 2022. "Control of non-REM sleep by ventrolateral medulla glutamatergic neurons projecting to the preoptic area," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

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