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Floor-plate-derived netrin-1 is dispensable for commissural axon guidance

Author

Listed:
  • Chloé Dominici

    (Sorbonne Universités, UPMC Paris 06, INSERM, CNRS, Institut de la Vision)

  • Juan Antonio Moreno-Bravo

    (Sorbonne Universités, UPMC Paris 06, INSERM, CNRS, Institut de la Vision)

  • Sergi Roig Puiggros

    (Sorbonne Universités, UPMC Paris 06, INSERM, CNRS, Institut de la Vision
    Apoptosis, Cancer and Development Laboratory, Equipe labellisée ‘La Ligue’, LabEx DEVweCAN, Centre de Recherche en Cancérologie de Lyon, INSERM U1052-CNRS UMR5286, Université de Lyon)

  • Quentin Rappeneau

    (Sorbonne Universités, UPMC Paris 06, INSERM, CNRS, Institut de la Vision)

  • Nicolas Rama

    (Apoptosis, Cancer and Development Laboratory, Equipe labellisée ‘La Ligue’, LabEx DEVweCAN, Centre de Recherche en Cancérologie de Lyon, INSERM U1052-CNRS UMR5286, Université de Lyon)

  • Pauline Vieugue

    (Apoptosis, Cancer and Development Laboratory, Equipe labellisée ‘La Ligue’, LabEx DEVweCAN, Centre de Recherche en Cancérologie de Lyon, INSERM U1052-CNRS UMR5286, Université de Lyon)

  • Agns Bernet

    (Apoptosis, Cancer and Development Laboratory, Equipe labellisée ‘La Ligue’, LabEx DEVweCAN, Centre de Recherche en Cancérologie de Lyon, INSERM U1052-CNRS UMR5286, Université de Lyon)

  • Patrick Mehlen

    (Apoptosis, Cancer and Development Laboratory, Equipe labellisée ‘La Ligue’, LabEx DEVweCAN, Centre de Recherche en Cancérologie de Lyon, INSERM U1052-CNRS UMR5286, Université de Lyon)

  • Alain Chédotal

    (Sorbonne Universités, UPMC Paris 06, INSERM, CNRS, Institut de la Vision)

Abstract

Preventing netrin secretion from floor-plate cells at the midline does not disrupt axonal guidance; commissural axons develop normally and the data suggest that netrin may influence axons locally by promoting growth cone adhesion.

Suggested Citation

  • Chloé Dominici & Juan Antonio Moreno-Bravo & Sergi Roig Puiggros & Quentin Rappeneau & Nicolas Rama & Pauline Vieugue & Agns Bernet & Patrick Mehlen & Alain Chédotal, 2017. "Floor-plate-derived netrin-1 is dispensable for commissural axon guidance," Nature, Nature, vol. 545(7654), pages 350-354, May.
    • Handle: RePEc:nat:nature:v:545:y:2017:i:7654:d:10.1038_nature22331
    DOI: 10.1038/nature22331
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    Cited by:

    1. F. Lapraz & C. Boutres & C. Fixary-Schuster & B. R. Queiroz & P. Y. Plaçais & D. Cerezo & F. Besse & T. Préat & S. Noselli, 2023. "Asymmetric activity of NetrinB controls laterality of the Drosophila brain," Nature Communications, Nature, vol. 14(1), pages 1-13, December.

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