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Intratumoural heterogeneity generated by Notch signalling promotes small-cell lung cancer

Author

Listed:
  • Jing Shan Lim

    (Stanford University School of Medicine
    Stanford University School of Medicine)

  • Alvaro Ibaseta

    (Stanford University School of Medicine
    Stanford University School of Medicine)

  • Marcus M. Fischer

    (OncoMed Pharmaceuticals, Inc.)

  • Belinda Cancilla

    (OncoMed Pharmaceuticals, Inc.)

  • Gilbert O’Young

    (OncoMed Pharmaceuticals, Inc.)

  • Sandra Cristea

    (Stanford University School of Medicine
    Stanford University School of Medicine)

  • Vincent C. Luca

    (Stanford University School of Medicine
    Stanford University School of Medicine
    Howard Hughes Medical Institute, Stanford University School of Medicine)

  • Dian Yang

    (Stanford University School of Medicine
    Stanford University School of Medicine)

  • Nadine S. Jahchan

    (Stanford University School of Medicine
    Stanford University School of Medicine)

  • Cécile Hamard

    (Sorbonne Universités, UPMC Univ Paris 06, GRC n°04
    AP-HP, Hôpital Tenon, Service de Pneumologie)

  • Martine Antoine

    (Sorbonne Universités, UPMC Univ Paris 06, GRC n°04
    AP-HP, Hôpital Tenon, Service de Pneumologie)

  • Marie Wislez

    (Sorbonne Universités, UPMC Univ Paris 06, GRC n°04
    AP-HP, Hôpital Tenon, Service de Pneumologie)

  • Christina Kong

    (Stanford University School of Medicine)

  • Jennifer Cain

    (OncoMed Pharmaceuticals, Inc.)

  • Yu-Wang Liu

    (OncoMed Pharmaceuticals, Inc.)

  • Ann M. Kapoun

    (OncoMed Pharmaceuticals, Inc.)

  • K. Christopher Garcia

    (Stanford University School of Medicine
    Stanford University School of Medicine
    Howard Hughes Medical Institute, Stanford University School of Medicine)

  • Timothy Hoey

    (OncoMed Pharmaceuticals, Inc.)

  • Christopher L. Murriel

    (OncoMed Pharmaceuticals, Inc.)

  • Julien Sage

    (Stanford University School of Medicine
    Stanford University School of Medicine)

Abstract

In a mouse model of small-cell lung cancer and in human tumours, activation of the Notch pathway can lead to a cell fate switch of neuroendocrine cells to less proliferative non-neuroendocrine cells, generating intratumoural heterogeneity.

Suggested Citation

  • Jing Shan Lim & Alvaro Ibaseta & Marcus M. Fischer & Belinda Cancilla & Gilbert O’Young & Sandra Cristea & Vincent C. Luca & Dian Yang & Nadine S. Jahchan & Cécile Hamard & Martine Antoine & Marie Wis, 2017. "Intratumoural heterogeneity generated by Notch signalling promotes small-cell lung cancer," Nature, Nature, vol. 545(7654), pages 360-364, May.
    • Handle: RePEc:nat:nature:v:545:y:2017:i:7654:d:10.1038_nature22323
    DOI: 10.1038/nature22323
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    Cited by:

    1. Maximilian W. Schenk & Sam Humphrey & A. S. Md Mukarram Hossain & Mitchell Revill & Sarah Pearsall & Alice Lallo & Stewart Brown & Samuel Bratt & Melanie Galvin & Tine Descamps & Cong Zhou & Simon P. , 2021. "Soluble guanylate cyclase signalling mediates etoposide resistance in progressing small cell lung cancer," Nature Communications, Nature, vol. 12(1), pages 1-15, December.
    2. Hsiao-Yun Chen & Yavuz T. Durmaz & Yixiang Li & Amin H. Sabet & Amir Vajdi & Thomas Denize & Emily Walton & Yasmin Nabil Laimon & John G. Doench & Navin R. Mahadevan & Julie-Aurore Losman & David A. B, 2022. "Regulation of neuroendocrine plasticity by the RNA-binding protein ZFP36L1," Nature Communications, Nature, vol. 13(1), pages 1-22, December.
    3. Yan Ting Shue & Alexandros P. Drainas & Nancy Yanzhe Li & Sarah M. Pearsall & Derrick Morgan & Nasa Sinnott-Armstrong & Susan Q. Hipkins & Garry L. Coles & Jing Shan Lim & Anthony E. Oro & Kathryn L. , 2022. "A conserved YAP/Notch/REST network controls the neuroendocrine cell fate in the lungs," Nature Communications, Nature, vol. 13(1), pages 1-18, December.

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