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Non-equivalence of Wnt and R-spondin ligands during Lgr5+ intestinal stem-cell self-renewal

Author

Listed:
  • Kelley S. Yan

    (Stanford University School of Medicine
    Columbia Center for Human Development, Columbia University Medical Center)

  • Claudia Y. Janda

    (Howard Hughes Medical Institute, Stanford University School of Medicine)

  • Junlei Chang

    (Stanford University School of Medicine)

  • Grace X. Y. Zheng

    (10x Genomics, Inc.)

  • Kathryn A. Larkin

    (Stanford University School of Medicine)

  • Vincent C. Luca

    (Howard Hughes Medical Institute, Stanford University School of Medicine)

  • Luis A. Chia

    (Stanford University School of Medicine)

  • Amanda T. Mah

    (Stanford University School of Medicine)

  • Arnold Han

    (Stanford University School of Medicine
    Columbia Center for Translational Immunology, Columbia University Medical Center)

  • Jessica M. Terry

    (10x Genomics, Inc.)

  • Akifumi Ootani

    (Stanford University School of Medicine)

  • Kelly Roelf

    (Stanford University School of Medicine)

  • Mark Lee

    (Stanford University School of Medicine)

  • Jenny Yuan

    (Stanford University School of Medicine)

  • Xiao Li

    (Stanford University School of Medicine)

  • Christopher R. Bolen

    (Stanford University School of Medicine)

  • Julie Wilhelmy

    (Stanford University School of Medicine)

  • Paige S. Davies

    (Oregon Health & Science University, Developmental and Cancer Biology)

  • Hiroo Ueno

    (Institute for Stem Cell Biology, Stanford University School of Medicine)

  • Richard J. von Furstenberg

    (University of North Carolina at Chapel Hill)

  • Phillip Belgrader

    (10x Genomics, Inc.)

  • Solongo B. Ziraldo

    (10x Genomics, Inc.)

  • Heather Ordonez

    (10x Genomics, Inc.)

  • Susan J. Henning

    (University of North Carolina at Chapel Hill)

  • Melissa H. Wong

    (Oregon Health & Science University, Developmental and Cancer Biology)

  • Michael P. Snyder

    (Stanford University School of Medicine)

  • Irving L. Weissman

    (Institute for Stem Cell Biology, Stanford University School of Medicine)

  • Aaron J. Hsueh

    (Stanford University School of Medicine)

  • Tarjei S. Mikkelsen

    (10x Genomics, Inc.)

  • K. Christopher Garcia

    (Howard Hughes Medical Institute, Stanford University School of Medicine)

  • Calvin J. Kuo

    (Stanford University School of Medicine)

Abstract

R-spondin and Wnt ligand families act non-redundantly and cooperatively within the same molecular pathway in the intestinal stem-cell niche to maintain stem-cell competency and drive stem-cell expansion.

Suggested Citation

  • Kelley S. Yan & Claudia Y. Janda & Junlei Chang & Grace X. Y. Zheng & Kathryn A. Larkin & Vincent C. Luca & Luis A. Chia & Amanda T. Mah & Arnold Han & Jessica M. Terry & Akifumi Ootani & Kelly Roelf , 2017. "Non-equivalence of Wnt and R-spondin ligands during Lgr5+ intestinal stem-cell self-renewal," Nature, Nature, vol. 545(7653), pages 238-242, May.
    • Handle: RePEc:nat:nature:v:545:y:2017:i:7653:d:10.1038_nature22313
    DOI: 10.1038/nature22313
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    Cited by:

    1. Christina M. Termini & Amara Pang & Tiancheng Fang & Martina Roos & Vivian Y. Chang & Yurun Zhang & Nicollette J. Setiawan & Lia Signaevskaia & Michelle Li & Mindy M. Kim & Orel Tabibi & Paulina K. Li, 2021. "Neuropilin 1 regulates bone marrow vascular regeneration and hematopoietic reconstitution," Nature Communications, Nature, vol. 12(1), pages 1-17, December.
    2. Jie Ding & Sung-Jin Lee & Lukas Vlahos & Kanako Yuki & Cara C. Rada & Vincent Unen & Meghah Vuppalapaty & Hui Chen & Asmiti Sura & Aaron K. McCormick & Madeline Tomaske & Samira Alwahabi & Huy Nguyen , 2023. "Therapeutic blood-brain barrier modulation and stroke treatment by a bioengineered FZD4-selective WNT surrogate in mice," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

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