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Cohesin is positioned in mammalian genomes by transcription, CTCF and Wapl

Author

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  • Georg A. Busslinger

    (Research Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC)
    †Present addresses: Hubrecht Institute, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands (G.A.B.); Gregor Mendel Institute of Molecular Plant Biology, Dr. Bohr-Gasse 3, A-1030 Vienna, Austria (E.A.); The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK (A.T.).)

  • Roman R. Stocsits

    (Research Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC))

  • Petra van der Lelij

    (Research Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC))

  • Elin Axelsson

    (Research Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC)
    †Present addresses: Hubrecht Institute, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands (G.A.B.); Gregor Mendel Institute of Molecular Plant Biology, Dr. Bohr-Gasse 3, A-1030 Vienna, Austria (E.A.); The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK (A.T.).)

  • Antonio Tedeschi

    (Research Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC)
    †Present addresses: Hubrecht Institute, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands (G.A.B.); Gregor Mendel Institute of Molecular Plant Biology, Dr. Bohr-Gasse 3, A-1030 Vienna, Austria (E.A.); The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK (A.T.).)

  • Niels Galjart

    (Erasmus Medical Center)

  • Jan-Michael Peters

    (Research Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC))

Abstract

The distribution of cohesin in the mouse genome depends on CTCF, transcription and the cohesin release factor Wapl.

Suggested Citation

  • Georg A. Busslinger & Roman R. Stocsits & Petra van der Lelij & Elin Axelsson & Antonio Tedeschi & Niels Galjart & Jan-Michael Peters, 2017. "Cohesin is positioned in mammalian genomes by transcription, CTCF and Wapl," Nature, Nature, vol. 544(7651), pages 503-507, April.
    • Handle: RePEc:nat:nature:v:544:y:2017:i:7651:d:10.1038_nature22063
    DOI: 10.1038/nature22063
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    Citations

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    Cited by:

    1. Ayantika Sen Gupta & Chris Seidel & Dai Tsuchiya & Sean McKinney & Zulin Yu & Sarah E. Smith & Jay R. Unruh & Jennifer L. Gerton, 2023. "Defining a core configuration for human centromeres during mitosis," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    2. Ryuichiro Nakato & Toyonori Sakata & Jiankang Wang & Luis Augusto Eijy Nagai & Yuya Nagaoka & Gina Miku Oba & Masashige Bando & Katsuhiko Shirahige, 2023. "Context-dependent perturbations in chromatin folding and the transcriptome by cohesin and related factors," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    3. Silvia Peripolli & Leticia Meneguello & Chiara Perrod & Tanya Singh & Harshil Patel & Sazia T. Rahman & Koshiro Kiso & Peter Thorpe & Vincenzo Calvanese & Cosetta Bertoli & Robertus A. M. de Bruin, 2024. "Oncogenic c-Myc induces replication stress by increasing cohesins chromatin occupancy in a CTCF-dependent manner," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    4. Daniel Bsteh & Hagar F. Moussa & Georg Michlits & Ramesh Yelagandula & Jingkui Wang & Ulrich Elling & Oliver Bell, 2023. "Loss of cohesin regulator PDS5A reveals repressive role of Polycomb loops," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    5. Hannah L. Harris & Huiya Gu & Moshe Olshansky & Ailun Wang & Irene Farabella & Yossi Eliaz & Achyuth Kalluchi & Akshay Krishna & Mozes Jacobs & Gesine Cauer & Melanie Pham & Suhas S. P. Rao & Olga Dud, 2023. "Chromatin alternates between A and B compartments at kilobase scale for subgenic organization," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    6. Hossein Salari & Geneviève Fourel & Daniel Jost, 2024. "Transcription regulates the spatio-temporal dynamics of genes through micro-compartmentalization," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    7. Aayush Kant & Zixian Guo & Vinayak Vinayak & Maria Victoria Neguembor & Wing Shun Li & Vasundhara Agrawal & Emily Pujadas & Luay Almassalha & Vadim Backman & Melike Lakadamyali & Maria Pia Cosma & Viv, 2024. "Active transcription and epigenetic reactions synergistically regulate meso-scale genomic organization," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    8. Evelyn Kabirova & Anastasiya Ryzhkova & Varvara Lukyanchikova & Anna Khabarova & Alexey Korablev & Tatyana Shnaider & Miroslav Nuriddinov & Polina Belokopytova & Alexander Smirnov & Nikita V. Khotskin, 2024. "TAD border deletion at the Kit locus causes tissue-specific ectopic activation of a neighboring gene," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    9. Jiankang Wang & Masashige Bando & Katsuhiko Shirahige & Ryuichiro Nakato, 2022. "Large-scale multi-omics analysis suggests specific roles for intragenic cohesin in transcriptional regulation," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    10. Dácil Alonso-Gil & Ana Cuadrado & Daniel Giménez-Llorente & Miriam Rodríguez-Corsino & Ana Losada, 2023. "Different NIPBL requirements of cohesin-STAG1 and cohesin-STAG2," Nature Communications, Nature, vol. 14(1), pages 1-11, December.

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