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Super-multiplex vibrational imaging

Author

Listed:
  • Lu Wei

    (Columbia University)

  • Zhixing Chen

    (Columbia University)

  • Lixue Shi

    (Columbia University)

  • Rong Long

    (Columbia University)

  • Andrew V. Anzalone

    (Columbia University)

  • Luyuan Zhang

    (Columbia University)

  • Fanghao Hu

    (Columbia University)

  • Rafael Yuste

    (NeuroTechnology Center, Columbia University
    Columbia University
    Kavli Institute for Brain Science, Columbia University)

  • Virginia W. Cornish

    (Columbia University
    NeuroTechnology Center, Columbia University)

  • Wei Min

    (Columbia University
    NeuroTechnology Center, Columbia University
    Kavli Institute for Brain Science, Columbia University)

Abstract

Stimulated Raman scattering under electronic pre-resonance conditions, combined with a new palette of probes, enables super-multiplex imaging of molecular targets in living cells with very high vibrational selectivity and sensitivity.

Suggested Citation

  • Lu Wei & Zhixing Chen & Lixue Shi & Rong Long & Andrew V. Anzalone & Luyuan Zhang & Fanghao Hu & Rafael Yuste & Virginia W. Cornish & Wei Min, 2017. "Super-multiplex vibrational imaging," Nature, Nature, vol. 544(7651), pages 465-470, April.
    • Handle: RePEc:nat:nature:v:544:y:2017:i:7651:d:10.1038_nature22051
    DOI: 10.1038/nature22051
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    Cited by:

    1. Yiyi Zhang & Sidan Tian & Liping Huang & Yanan Li & Yuan Lu & Hongyu Li & Guiping Chen & Fanling Meng & Gang L. Liu & Xiangliang Yang & Jiasheng Tu & Chunmeng Sun & Liang Luo, 2022. "Reactive oxygen species-responsive and Raman-traceable hydrogel combining photodynamic and immune therapy for postsurgical cancer treatment," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    2. Sandro Heuke & Hervé Rigneault, 2023. "Coherent Stokes Raman scattering microscopy (CSRS)," Nature Communications, Nature, vol. 14(1), pages 1-8, December.
    3. Yueli Yang & Xueyang Bai & Fanghao Hu, 2024. "Photoswitchable polyynes for multiplexed stimulated Raman scattering microscopy with reversible light control," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    4. Yingfeng Tao & Xiaoliu Zhou & Leqiang Sun & Da Lin & Huaiyuan Cai & Xi Chen & Wei Zhou & Bing Yang & Zhe Hu & Jing Yu & Jing Zhang & Xiaoqing Yang & Fang Yang & Bang Shen & Wenbao Qi & Zhenfang Fu & J, 2023. "Highly efficient and robust π-FISH rainbow for multiplexed in situ detection of diverse biomolecules," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    5. Raja Chouket & Agnès Pellissier-Tanon & Aliénor Lahlou & Ruikang Zhang & Diana Kim & Marie-Aude Plamont & Mingshu Zhang & Xi Zhang & Pingyong Xu & Nicolas Desprat & Dominique Bourgeois & Agathe Espagn, 2022. "Extra kinetic dimensions for label discrimination," Nature Communications, Nature, vol. 13(1), pages 1-8, December.
    6. Xiujuan Gao & Xinyuan Huang & Zhongyun Chen & Liu Yang & Yifu Zhou & Zhenxuan Hou & Jie Yang & Shuhong Qi & Zheng Liu & Zhihong Zhang & Qian Liu & Qingming Luo & Ling Fu, 2024. "Supercontinuum-tailoring multicolor imaging reveals spatiotemporal dynamics of heterogeneous tumor evolution," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    7. Xiaomeng Han & Xiaotang Lu & Peter H. Li & Shuohong Wang & Richard Schalek & Yaron Meirovitch & Zudi Lin & Jason Adhinarta & Karl D. Murray & Leah M. MacNiven & Daniel R. Berger & Yuelong Wu & Tao Fan, 2024. "Multiplexed volumetric CLEM enabled by scFvs provides insights into the cytology of cerebellar cortex," Nature Communications, Nature, vol. 15(1), pages 1-18, December.

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