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Mutual regulation of tumour vessel normalization and immunostimulatory reprogramming

Author

Listed:
  • Lin Tian

    (Lester and Sue Smith Breast Center, Baylor College of Medicine, One Baylor Plaza
    Dan L. Duncan Cancer Center, Baylor College of Medicine, One Baylor Plaza
    Baylor College of Medicine, One Baylor Plaza)

  • Amit Goldstein

    (Lester and Sue Smith Breast Center, Baylor College of Medicine, One Baylor Plaza
    Dan L. Duncan Cancer Center, Baylor College of Medicine, One Baylor Plaza
    Baylor College of Medicine, One Baylor Plaza)

  • Hai Wang

    (Lester and Sue Smith Breast Center, Baylor College of Medicine, One Baylor Plaza
    Dan L. Duncan Cancer Center, Baylor College of Medicine, One Baylor Plaza
    Baylor College of Medicine, One Baylor Plaza)

  • Hin Ching Lo

    (Lester and Sue Smith Breast Center, Baylor College of Medicine, One Baylor Plaza
    Dan L. Duncan Cancer Center, Baylor College of Medicine, One Baylor Plaza
    Graduate Program in Integrative Molecular and Biomedical Sciences, Baylor College of Medicine, One Baylor Plaza)

  • Ik Sun Kim

    (Lester and Sue Smith Breast Center, Baylor College of Medicine, One Baylor Plaza
    Dan L. Duncan Cancer Center, Baylor College of Medicine, One Baylor Plaza
    Graduate Program in Integrative Molecular and Biomedical Sciences, Baylor College of Medicine, One Baylor Plaza)

  • Thomas Welte

    (Lester and Sue Smith Breast Center, Baylor College of Medicine, One Baylor Plaza
    Dan L. Duncan Cancer Center, Baylor College of Medicine, One Baylor Plaza
    Baylor College of Medicine, One Baylor Plaza)

  • Kuanwei Sheng

    (Graduate Program in Integrative Molecular and Biomedical Sciences, Baylor College of Medicine, One Baylor Plaza
    Baylor College of Medicine, One Baylor Plaza)

  • Lacey E. Dobrolecki

    (Lester and Sue Smith Breast Center, Baylor College of Medicine, One Baylor Plaza)

  • Xiaomei Zhang

    (Lester and Sue Smith Breast Center, Baylor College of Medicine, One Baylor Plaza)

  • Nagireddy Putluri

    (Dan L. Duncan Cancer Center, Baylor College of Medicine, One Baylor Plaza
    Baylor College of Medicine, One Baylor Plaza
    Baylor College of Medicine, One Baylor Plaza)

  • Thuy L. Phung

    (Baylor College of Medicine, One Baylor Plaza)

  • Sendurai A. Mani

    (MD Anderson Cancer Center)

  • Fabio Stossi

    (Dan L. Duncan Cancer Center, Baylor College of Medicine, One Baylor Plaza
    Baylor College of Medicine, One Baylor Plaza)

  • Arun Sreekumar

    (Dan L. Duncan Cancer Center, Baylor College of Medicine, One Baylor Plaza
    Baylor College of Medicine, One Baylor Plaza
    Baylor College of Medicine, One Baylor Plaza)

  • Michael A. Mancini

    (Dan L. Duncan Cancer Center, Baylor College of Medicine, One Baylor Plaza
    Baylor College of Medicine, One Baylor Plaza)

  • William K. Decker

    (Dan L. Duncan Cancer Center, Baylor College of Medicine, One Baylor Plaza
    Baylor College of Medicine, One Baylor Plaza
    Center for Cell and Gene Therapy, Baylor College of Medicine, One Baylor Plaza)

  • Chenghang Zong

    (Dan L. Duncan Cancer Center, Baylor College of Medicine, One Baylor Plaza
    Graduate Program in Integrative Molecular and Biomedical Sciences, Baylor College of Medicine, One Baylor Plaza
    Baylor College of Medicine, One Baylor Plaza
    McNair Medical Institute, Baylor College of Medicine, One Baylor Plaza)

  • Michael T. Lewis

    (Lester and Sue Smith Breast Center, Baylor College of Medicine, One Baylor Plaza
    Dan L. Duncan Cancer Center, Baylor College of Medicine, One Baylor Plaza
    Baylor College of Medicine, One Baylor Plaza)

  • Xiang H.-F. Zhang

    (Lester and Sue Smith Breast Center, Baylor College of Medicine, One Baylor Plaza
    Dan L. Duncan Cancer Center, Baylor College of Medicine, One Baylor Plaza
    Baylor College of Medicine, One Baylor Plaza
    McNair Medical Institute, Baylor College of Medicine, One Baylor Plaza)

Abstract

The cross-talk between immune cells and blood vessel endothelial cells promotes pericyte coverage and decreases hypoxia in mouse tumour models, and correlative evidence suggests that these processes influence cancer prognosis in humans.

Suggested Citation

  • Lin Tian & Amit Goldstein & Hai Wang & Hin Ching Lo & Ik Sun Kim & Thomas Welte & Kuanwei Sheng & Lacey E. Dobrolecki & Xiaomei Zhang & Nagireddy Putluri & Thuy L. Phung & Sendurai A. Mani & Fabio Sto, 2017. "Mutual regulation of tumour vessel normalization and immunostimulatory reprogramming," Nature, Nature, vol. 544(7649), pages 250-254, April.
    • Handle: RePEc:nat:nature:v:544:y:2017:i:7649:d:10.1038_nature21724
    DOI: 10.1038/nature21724
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    Cited by:

    1. Wu-tong Ju & Rong-hui Xia & Dong-wang Zhu & Sheng-jin Dou & Guo-pei Zhu & Min-jun Dong & Li-zhen Wang & Qi Sun & Tong-chao Zhao & Zhi-hang Zhou & Si-yuan Liang & Ying-ying Huang & Yong Tang & Si-cheng, 2022. "A pilot study of neoadjuvant combination of anti-PD-1 camrelizumab and VEGFR2 inhibitor apatinib for locally advanced resectable oral squamous cell carcinoma," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    2. Hongwei Lv & Qianni Zong & Cian Chen & Guishuai Lv & Wei Xiang & Fuxue Xing & Guoqing Jiang & Bing Yan & Xiaoyan Sun & Yue Ma & Liang Wang & Zixin Wu & Xiuliang Cui & Hongyang Wang & Wen Yang, 2024. "TET2-mediated tumor cGAS triggers endothelial STING activation to regulate vasculature remodeling and anti-tumor immunity in liver cancer," Nature Communications, Nature, vol. 15(1), pages 1-21, December.
    3. Huan Chen & Ting Li & Zhiyong Liu & Shuwan Tang & Jintao Tong & Yingfang Tao & Zinan Zhao & Nan Li & Chun Mao & Jian Shen & Mimi Wan, 2023. "A nitric-oxide driven chemotactic nanomotor for enhanced immunotherapy of glioblastoma," Nature Communications, Nature, vol. 14(1), pages 1-21, December.

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