IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v13y2022i1d10.1038_s41467-022-33080-8.html
   My bibliography  Save this article

A pilot study of neoadjuvant combination of anti-PD-1 camrelizumab and VEGFR2 inhibitor apatinib for locally advanced resectable oral squamous cell carcinoma

Author

Listed:
  • Wu-tong Ju

    (Shanghai Jiao Tong University School of Medicine)

  • Rong-hui Xia

    (Shanghai Jiao Tong University School of Medicine)

  • Dong-wang Zhu

    (Shanghai Jiao Tong University School of Medicine)

  • Sheng-jin Dou

    (Shanghai Jiao Tong University School of Medicine)

  • Guo-pei Zhu

    (Shanghai Jiao Tong University School of Medicine)

  • Min-jun Dong

    (Shanghai Jiao Tong University School of Medicine)

  • Li-zhen Wang

    (Shanghai Jiao Tong University School of Medicine)

  • Qi Sun

    (Shanghai Jiao Tong University School of Medicine)

  • Tong-chao Zhao

    (Shanghai Jiao Tong University School of Medicine)

  • Zhi-hang Zhou

    (Shanghai Jiao Tong University School of Medicine)

  • Si-yuan Liang

    (Shanghai Jiao Tong University School of Medicine)

  • Ying-ying Huang

    (Shanghai Jiao Tong University School of Medicine)

  • Yong Tang

    (Shanghai Jiao Tong University School of Medicine)

  • Si-cheng Wu

    (Shanghai Jiao Tong University School of Medicine)

  • Jing Xia

    (The Medical Department, 3D Medicines Inc.)

  • Shi-qing Chen

    (The Medical Department, 3D Medicines Inc.)

  • Yue-zong Bai

    (The Medical Department, 3D Medicines Inc.)

  • Jiang Li

    (Shanghai Jiao Tong University School of Medicine)

  • Qi Zhu

    (Shanghai Jiao Tong University School of Medicine)

  • Lai-ping Zhong

    (Shanghai Jiao Tong University School of Medicine
    National Center for Stomatology
    National Clinical Research Center for Oral Diseases
    Shanghai Key Laboratory of Stomatology)

Abstract

Novel neoadjuvant therapy regimens are warranted for oral squamous cell carcinoma (OSCC). In this phase I trial (NCT04393506), 20 patients with locally advanced resectable OSCC receive three cycles of camrelizumab (200 mg, q2w) and apatinib (250 mg, once daily) before surgery. The primary endpoints are safety and major pathological response (MPR, defined as ≤10% residual viable tumour cells). Secondary endpoints include 2-year survival rate and local recurrence rate (not reported due to inadequate follow-up). Exploratory endpoints are the relationships between PD-L1 combined positive score (CPS, defined as the number of PD-L1-stained cells divided by the total number of viable tumour cells, multiplied by 100) and other immunological and genomic biomarkers and response. Neoadjuvant treatment is well-tolerated, and the MPR rate is 40% (8/20), meeting the primary endpoint. All five patients with CPS ˃10 achieve MPR. Post-hoc analysis show 18-month locoregional recurrence and survival rates of 10.5% (95% CI: 0%–24.3%) and 95% (95% CI: 85.4%–100.0%), respectively. Patients achieving MPR show more CD4+ T-cell infiltration than those without MPR (P = 0.02), and decreased CD31 and ɑ-SMA expression levels are observed after neoadjuvant therapy. In conclusion, neoadjuvant camrelizumab and apatinib is safe and yields a promising MPR rate for OSCC.

Suggested Citation

  • Wu-tong Ju & Rong-hui Xia & Dong-wang Zhu & Sheng-jin Dou & Guo-pei Zhu & Min-jun Dong & Li-zhen Wang & Qi Sun & Tong-chao Zhao & Zhi-hang Zhou & Si-yuan Liang & Ying-ying Huang & Yong Tang & Si-cheng, 2022. "A pilot study of neoadjuvant combination of anti-PD-1 camrelizumab and VEGFR2 inhibitor apatinib for locally advanced resectable oral squamous cell carcinoma," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
  • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-33080-8
    DOI: 10.1038/s41467-022-33080-8
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-022-33080-8
    File Function: Abstract
    Download Restriction: no

    File URL: https://libkey.io/10.1038/s41467-022-33080-8?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Joris L. Vos & Joris B. W. Elbers & Oscar Krijgsman & Joleen J. H. Traets & Xiaohang Qiao & Anne M. Leun & Yoni Lubeck & Iris M. Seignette & Laura A. Smit & Stefan M. Willems & Michiel W. M. Brekel & , 2021. "Neoadjuvant immunotherapy with nivolumab and ipilimumab induces major pathological responses in patients with head and neck squamous cell carcinoma," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    2. Lin Tian & Amit Goldstein & Hai Wang & Hin Ching Lo & Ik Sun Kim & Thomas Welte & Kuanwei Sheng & Lacey E. Dobrolecki & Xiaomei Zhang & Nagireddy Putluri & Thuy L. Phung & Sendurai A. Mani & Fabio Sto, 2017. "Mutual regulation of tumour vessel normalization and immunostimulatory reprogramming," Nature, Nature, vol. 544(7649), pages 250-254, April.
    3. Rebekka Duhen & Carmen Ballesteros-Merino & Alexandra K. Frye & Eric Tran & Venkatesh Rajamanickam & Shu-Ching Chang & Yoshinobu Koguchi & Carlo B. Bifulco & Brady Bernard & Rom S. Leidner & Brendan D, 2021. "Neoadjuvant anti-OX40 (MEDI6469) therapy in patients with head and neck squamous cell carcinoma activates and expands antigen-specific tumor-infiltrating T cells," Nature Communications, Nature, vol. 12(1), pages 1-14, December.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Li Yuan & Guo-Dong Jia & Xiao-Fei Lv & Si-Yi Xie & Shan-Shan Guo & Da-Feng Lin & Li-Ting Liu & Dong-Hua Luo & Yi-Fu Li & Shen-Wen Deng & Ling Guo & Mu-Sheng Zeng & Xiu-Yu Cai & Sai-Lan Liu & Xue-Song , 2023. "Camrelizumab combined with apatinib in patients with first-line platinum-resistant or PD-1 inhibitor resistant recurrent/metastatic nasopharyngeal carcinoma: a single-arm, phase 2 trial," Nature Communications, Nature, vol. 14(1), pages 1-17, December.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Tara Muijlwijk & Irene H. Nauta & Anabel Lee & Kari J. T. Grünewald & Arjen Brink & Sonja H. Ganzevles & Robert J. Baatenburg de Jong & Lilit Atanesyan & Suvi Savola & Mark A. Wiel & Laura A. N. Pefer, 2024. "Hallmarks of a genomically distinct subclass of head and neck cancer," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    2. Hongwei Lv & Qianni Zong & Cian Chen & Guishuai Lv & Wei Xiang & Fuxue Xing & Guoqing Jiang & Bing Yan & Xiaoyan Sun & Yue Ma & Liang Wang & Zixin Wu & Xiuliang Cui & Hongyang Wang & Wen Yang, 2024. "TET2-mediated tumor cGAS triggers endothelial STING activation to regulate vasculature remodeling and anti-tumor immunity in liver cancer," Nature Communications, Nature, vol. 15(1), pages 1-21, December.
    3. Di Wu & Yong Li & Pengfei Xu & Qi Fang & Fei Cao & Hongsheng Lin & Yin Li & Yong Su & Lixia Lu & Lei Chen & Yizhuo Li & Zheng zhao & Xiaoyu Hong & Guohong Li & Yaru Tian & Jinyun Sun & Honghong Yan & , 2024. "Neoadjuvant chemo-immunotherapy with camrelizumab plus nab-paclitaxel and cisplatin in resectable locally advanced squamous cell carcinoma of the head and neck: a pilot phase II trial," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    4. Huan Chen & Ting Li & Zhiyong Liu & Shuwan Tang & Jintao Tong & Yingfang Tao & Zinan Zhao & Nan Li & Chun Mao & Jian Shen & Mimi Wan, 2023. "A nitric-oxide driven chemotactic nanomotor for enhanced immunotherapy of glioblastoma," Nature Communications, Nature, vol. 14(1), pages 1-21, December.
    5. Alberto Gil-Jimenez & Nick Dijk & Joris L. Vos & Yoni Lubeck & Maurits L. Montfoort & Dennis Peters & Erik Hooijberg & Annegien Broeks & Charlotte L. Zuur & Bas W. G. Rhijn & Daniel J. Vis & Michiel S, 2024. "Spatial relationships in the urothelial and head and neck tumor microenvironment predict response to combination immune checkpoint inhibitors," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    6. Laurel B. Darragh & Jacob Gadwa & Tiffany T. Pham & Benjamin Court & Brooke Neupert & Nicholas A. Olimpo & Khoa Nguyen & Diemmy Nguyen & Michael W. Knitz & Maureen Hoen & Sophia Corbo & Molishree Josh, 2022. "Elective nodal irradiation mitigates local and systemic immunity generated by combination radiation and immunotherapy in head and neck tumors," Nature Communications, Nature, vol. 13(1), pages 1-18, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-33080-8. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.