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RNA m6A methylation regulates the ultraviolet-induced DNA damage response

Author

Listed:
  • Yang Xiang

    (Boston Children’s Hospital
    Harvard Medical School)

  • Benoit Laurent

    (Boston Children’s Hospital
    Harvard Medical School)

  • Chih-Hung Hsu

    (Boston Children’s Hospital
    Harvard Medical School)

  • Sigrid Nachtergaele

    (University of Chicago
    Institute for Biophysical Dynamics, University of Chicago
    Howard Hughes Medical Institute, University of Chicago)

  • Zhike Lu

    (University of Chicago
    Institute for Biophysical Dynamics, University of Chicago
    Howard Hughes Medical Institute, University of Chicago)

  • Wanqiang Sheng

    (Boston Children’s Hospital
    Harvard Medical School)

  • Chuanyun Xu

    (Boston Children’s Hospital
    Harvard Medical School)

  • Hao Chen

    (Boston Children’s Hospital
    Harvard Medical School)

  • Jian Ouyang

    (Massachusetts General Hospital Cancer Center, Harvard Medical School
    Massachusetts General Hospital Cancer Center, Harvard Medical School)

  • Siqing Wang

    (Boston Children’s Hospital
    Harvard Medical School
    †Present address: Institutes of Biomedical Sciences, Fudan University, Shanghai, China.)

  • Dominic Ling

    (Boston Children’s Hospital
    Harvard Medical School)

  • Pang-Hung Hsu

    (National Taiwan Ocean University)

  • Lee Zou

    (Massachusetts General Hospital Cancer Center, Harvard Medical School
    Massachusetts General Hospital Cancer Center, Harvard Medical School)

  • Ashwini Jambhekar

    (Boston Children’s Hospital
    Harvard Medical School)

  • Chuan He

    (University of Chicago
    Institute for Biophysical Dynamics, University of Chicago
    Howard Hughes Medical Institute, University of Chicago)

  • Yang Shi

    (Boston Children’s Hospital
    Harvard Medical School)

Abstract

Methylation at the 6 position of adenosine (m6A) in RNA is rapidly and transiently induced at DNA damage sites in response to ultraviolet irradiation.

Suggested Citation

  • Yang Xiang & Benoit Laurent & Chih-Hung Hsu & Sigrid Nachtergaele & Zhike Lu & Wanqiang Sheng & Chuanyun Xu & Hao Chen & Jian Ouyang & Siqing Wang & Dominic Ling & Pang-Hung Hsu & Lee Zou & Ashwini Ja, 2017. "RNA m6A methylation regulates the ultraviolet-induced DNA damage response," Nature, Nature, vol. 543(7646), pages 573-576, March.
    • Handle: RePEc:nat:nature:v:543:y:2017:i:7646:d:10.1038_nature21671
    DOI: 10.1038/nature21671
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    Cited by:

    1. Yuanpei Li & Xiaoniu He & Xiao Lu & Zhicheng Gong & Qing Li & Lei Zhang & Ronghui Yang & Chengyi Wu & Jialiang Huang & Jiancheng Ding & Yaohui He & Wen Liu & Ceshi Chen & Bin Cao & Dawang Zhou & Yufen, 2022. "METTL3 acetylation impedes cancer metastasis via fine-tuning its nuclear and cytosolic functions," Nature Communications, Nature, vol. 13(1), pages 1-23, December.
    2. Xiang Zhang & Huilong Yin & Xiaofang Zhang & Xunliang Jiang & Yongkang Liu & Haolin Zhang & Yingran Peng & Da Li & Yanping Yu & Jinbao Zhang & Shuli Cheng & Angang Yang & Rui Zhang, 2022. "N6-methyladenosine modification governs liver glycogenesis by stabilizing the glycogen synthase 2 mRNA," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    3. Alexandra E. Perlegos & Emily J. Shields & Hui Shen & Kathy Fange Liu & Nancy M. Bonini, 2022. "Mettl3-dependent m6A modification attenuates the brain stress response in Drosophila," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    4. Anthony Khong & Tyler Matheny & Thao Ngoc Huynh & Vincent Babl & Roy Parker, 2022. "Limited effects of m6A modification on mRNA partitioning into stress granules," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    5. Hongxia Chen & Xi Zhao & Wei Yang & Qi Zhang & Rongjiao Hao & Siao Jiang & Huihui Han & Zuyin Yu & Shuang Xing & Changjiang Feng & Qianqian Wang & Hao Lu & Yuanfeng Li & Cheng Quan & Yiming Lu & Gangq, 2023. "RNA N6-methyladenosine modification-based biomarkers for absorbed ionizing radiation dose estimation," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

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