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Survival of tissue-resident memory T cells requires exogenous lipid uptake and metabolism

Author

Listed:
  • Youdong Pan

    (Brigham and Women’s Hospital, Boston, Harvard Medical School)

  • Tian Tian

    (Brigham and Women’s Hospital, Boston, Harvard Medical School)

  • Chang Ook Park

    (Brigham and Women’s Hospital, Boston, Harvard Medical School)

  • Serena Y. Lofftus

    (Brigham and Women’s Hospital, Boston, Harvard Medical School)

  • Shenglin Mei

    (Center for Functional Epigenetics, Dana-Farber Cancer Institute)

  • Xing Liu

    (Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Harvard Medical School)

  • Chi Luo

    (Dana Farber Cancer Institute, Harvard Medical School)

  • John T. O’Malley

    (Brigham and Women’s Hospital, Boston, Harvard Medical School)

  • Ahmed Gehad

    (Brigham and Women’s Hospital, Boston, Harvard Medical School)

  • Jessica E. Teague

    (Brigham and Women’s Hospital, Boston, Harvard Medical School)

  • Sherrie J. Divito

    (Brigham and Women’s Hospital, Boston, Harvard Medical School)

  • Robert Fuhlbrigge

    (Brigham and Women’s Hospital, Boston, Harvard Medical School)

  • Pere Puigserver

    (Dana Farber Cancer Institute, Harvard Medical School)

  • James G. Krueger

    (Rockefeller University)

  • Gökhan S. Hotamisligil

    (Harvard T.H. Chan School of Public Health)

  • Rachael A. Clark

    (Brigham and Women’s Hospital, Boston, Harvard Medical School
    Dana-Farber/Brigham and Women’s Cancer Center)

  • Thomas S. Kupper

    (Brigham and Women’s Hospital, Boston, Harvard Medical School
    Dana-Farber/Brigham and Women’s Cancer Center)

Abstract

FABP4 and FABP5 are important for the maintenance, longevity and function of CD8+ tissue-resident memory T cells, which use oxidative metabolism of exogenous free fatty acids to persist in tissues and to mediate protective immunity.

Suggested Citation

  • Youdong Pan & Tian Tian & Chang Ook Park & Serena Y. Lofftus & Shenglin Mei & Xing Liu & Chi Luo & John T. O’Malley & Ahmed Gehad & Jessica E. Teague & Sherrie J. Divito & Robert Fuhlbrigge & Pere Pui, 2017. "Survival of tissue-resident memory T cells requires exogenous lipid uptake and metabolism," Nature, Nature, vol. 543(7644), pages 252-256, March.
    • Handle: RePEc:nat:nature:v:543:y:2017:i:7644:d:10.1038_nature21379
    DOI: 10.1038/nature21379
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    Citations

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    Cited by:

    1. Nicole L. Bertschi & Oliver Steck & Fabian Luther & Cecilia Bazzini & Leonhard Meyenn & Stefanie Schärli & Angela Vallone & Andrea Felser & Irene Keller & Olivier Friedli & Stefan Freigang & Nadja Beg, 2023. "PPAR-γ regulates the effector function of human T helper 9 cells by promoting glycolysis," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    2. Jake Lin & Elaheh Moradi & Karoliina Salenius & Suvi Lehtipuro & Tomi Häkkinen & Jutta E. Laiho & Sami Oikarinen & Sofia Randelin & Hemang M. Parikh & Jeffrey P. Krischer & Jorma Toppari & Åke Lernmar, 2023. "Distinct transcriptomic profiles in children prior to the appearance of type 1 diabetes-linked islet autoantibodies and following enterovirus infection," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    3. Yuxian Guo & Yaru Liu & Shihao Zhao & Wangting Xu & Yiqing Li & Pengwei Zhao & Di Wang & Hongqiang Cheng & Yuehai Ke & Xue Zhang, 2021. "Oxidative stress-induced FABP5 S-glutathionylation protects against acute lung injury by suppressing inflammation in macrophages," Nature Communications, Nature, vol. 12(1), pages 1-18, December.
    4. Matteo Villa & David E. Sanin & Petya Apostolova & Mauro Corrado & Agnieszka M. Kabat & Carmine Cristinzio & Annamaria Regina & Gustavo E. Carrizo & Nisha Rana & Michal A. Stanczak & Francesc Baixauli, 2024. "Prostaglandin E2 controls the metabolic adaptation of T cells to the intestinal microenvironment," Nature Communications, Nature, vol. 15(1), pages 1-19, December.

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