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mTORC1 and muscle regeneration are regulated by the LINC00961-encoded SPAR polypeptide

Author

Listed:
  • Akinobu Matsumoto

    (Cancer Research Institute, Beth Israel Deaconess Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Alessandra Pasut

    (Cancer Research Institute, Beth Israel Deaconess Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Masaki Matsumoto

    (Medical Institute of Bioregulation, Kyushu University)

  • Riu Yamashita

    (Tohoku Medical Megabank Organization (ToMMo), Tohoku University)

  • Jacqueline Fung

    (Cancer Research Institute, Beth Israel Deaconess Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Emanuele Monteleone

    (Cancer Research Institute, Beth Israel Deaconess Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School
    University of Turin)

  • Alan Saghatelian

    (The Clayton Foundation Laboratories for Peptide Biology, Helmsley Center for Genomic Medicine, Salk Institute for Biological Studies)

  • Keiichi I. Nakayama

    (Medical Institute of Bioregulation, Kyushu University)

  • John G. Clohessy

    (Cancer Research Institute, Beth Israel Deaconess Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Pier Paolo Pandolfi

    (Cancer Research Institute, Beth Israel Deaconess Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School)

Abstract

The polypeptide SPAR is encoded by a long non-coding RNA, localizes to the late endosome and lysosome, and regulates muscle regeneration by inhibiting mTORC1.

Suggested Citation

  • Akinobu Matsumoto & Alessandra Pasut & Masaki Matsumoto & Riu Yamashita & Jacqueline Fung & Emanuele Monteleone & Alan Saghatelian & Keiichi I. Nakayama & John G. Clohessy & Pier Paolo Pandolfi, 2017. "mTORC1 and muscle regeneration are regulated by the LINC00961-encoded SPAR polypeptide," Nature, Nature, vol. 541(7636), pages 228-232, January.
    • Handle: RePEc:nat:nature:v:541:y:2017:i:7636:d:10.1038_nature21034
    DOI: 10.1038/nature21034
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    Cited by:

    1. Shintaro Mise & Akinobu Matsumoto & Keisuke Shimada & Toshiaki Hosaka & Masatomo Takahashi & Kazuya Ichihara & Hideyuki Shimizu & Chisa Shiraishi & Daisuke Saito & Mikita Suyama & Tomoharu Yasuda & To, 2022. "Kastor and Polluks polypeptides encoded by a single gene locus cooperatively regulate VDAC and spermatogenesis," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    2. Haipeng Fu & Tingyu Wang & Xiaohui Kong & Kun Yan & Yang Yang & Jingyi Cao & Yafei Yuan & Nan Wang & Kehkooi Kee & Zhi John Lu & Qiaoran Xi, 2022. "A Nodal enhanced micropeptide NEMEP regulates glucose uptake during mesendoderm differentiation of embryonic stem cells," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    3. Caroline E. Brun & Marie-Claude Sincennes & Alexander Y. T. Lin & Derek Hall & William Jarassier & Peter Feige & Fabien Le Grand & Michael A. Rudnicki, 2022. "GLI3 regulates muscle stem cell entry into GAlert and self-renewal," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    4. Olga Boix & Marion Martinez & Santiago Vidal & Marta Giménez-Alejandre & Lluís Palenzuela & Laura Lorenzo-Sanz & Laura Quevedo & Olivier Moscoso & Jorge Ruiz-Orera & Pilar Ximénez-Embún & Nikaoly Ciri, 2022. "pTINCR microprotein promotes epithelial differentiation and suppresses tumor growth through CDC42 SUMOylation and activation," Nature Communications, Nature, vol. 13(1), pages 1-22, December.

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