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Hypoxia induces heart regeneration in adult mice

Author

Listed:
  • Yuji Nakada

    (University of Texas Southwestern Medical Center)

  • Diana C. Canseco

    (University of Texas Southwestern Medical Center)

  • SuWannee Thet

    (University of Texas Southwestern Medical Center)

  • Salim Abdisalaam

    (University of Texas Southwestern Medical Center)

  • Aroumougame Asaithamby

    (University of Texas Southwestern Medical Center)

  • Celio X. Santos

    (King’s College London BHF Centre of Research Excellence, Faculty of Medicine, James Black Centre)

  • Ajay M. Shah

    (King’s College London BHF Centre of Research Excellence, Faculty of Medicine, James Black Centre)

  • Hua Zhang

    (McAllister Heart Institute, the University of North Carolina)

  • James E. Faber

    (McAllister Heart Institute, the University of North Carolina)

  • Michael T. Kinter

    (Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation)

  • Luke I. Szweda

    (Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation)

  • Chao Xing

    (McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center)

  • Zeping Hu

    (Children’s Medical Center Research Institute at UT Southwestern Medical Center)

  • Ralph J. Deberardinis

    (Children’s Medical Center Research Institute at UT Southwestern Medical Center)

  • Gabriele Schiattarella

    (University of Texas Southwestern Medical Center)

  • Joseph A. Hill

    (University of Texas Southwestern Medical Center)

  • Orhan Oz

    (University of Texas Southwestern Medical Center)

  • Zhigang Lu

    (University of Texas Southwestern Medical Center)

  • Cheng Cheng Zhang

    (University of Texas Southwestern Medical Center)

  • Wataru Kimura

    (University of Texas Southwestern Medical Center
    Life Science Center, Tsukuba Advanced Research Alliance, University of Tsukuba, 1-1-1 Tennoudai)

  • Hesham A. Sadek

    (University of Texas Southwestern Medical Center
    Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center)

Abstract

A pathway triggered by chronic severe hypoxia boosts regeneration of injured hearts in adult mice.

Suggested Citation

  • Yuji Nakada & Diana C. Canseco & SuWannee Thet & Salim Abdisalaam & Aroumougame Asaithamby & Celio X. Santos & Ajay M. Shah & Hua Zhang & James E. Faber & Michael T. Kinter & Luke I. Szweda & Chao Xin, 2017. "Hypoxia induces heart regeneration in adult mice," Nature, Nature, vol. 541(7636), pages 222-227, January.
    • Handle: RePEc:nat:nature:v:541:y:2017:i:7636:d:10.1038_nature20173
    DOI: 10.1038/nature20173
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    Citations

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    Cited by:

    1. Slobodan Vukicevic & Andrea Colliva & Vera Kufner & Valentina Martinelli & Silvia Moimas & Simone Vodret & Viktorija Rumenovic & Milan Milosevic & Boris Brkljacic & Diana Delic-Brkljacic & Ricardo Cor, 2022. "Bone morphogenetic protein 1.3 inhibition decreases scar formation and supports cardiomyocyte survival after myocardial infarction," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    2. Donghong Zhang & Jinfeng Ning & Tharmarajan Ramprasath & Changjiang Yu & Xiaoxu Zheng & Ping Song & Zhonglin Xie & Ming-Hui Zou, 2022. "Kynurenine promotes neonatal heart regeneration by stimulating cardiomyocyte proliferation and cardiac angiogenesis," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    3. Wenya Ma & Yanan Tian & Leping Shi & Jing Liang & Qimeng Ouyang & Jianglong Li & Hongyang Chen & Hongyue Sun & Haoyu Ji & Xu Liu & Wei Huang & Xinlu Gao & Xiaoyan Jin & Xiuxiu Wang & Yining Liu & Yang, 2024. "N-Acetyltransferase 10 represses Uqcr11 and Uqcrb independently of ac4C modification to promote heart regeneration," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    4. Athanasios Drigas & Eleni Mitsea, 2022. "Breathing: a Powerfull Tool for Physical & Neuropsychological Regulation. The role of Mobile Apps," Technium Social Sciences Journal, Technium Science, vol. 28(1), pages 135-158, February.

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