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Integrin-YAP/TAZ-JNK cascade mediates atheroprotective effect of unidirectional shear flow

Author

Listed:
  • Li Wang

    (Institute of Vascular Medicine, Shenzhen Research Institute and Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong
    School of Biomedical Sciences, Chinese University of Hong Kong)

  • Jiang-Yun Luo

    (Institute of Vascular Medicine, Shenzhen Research Institute and Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong
    School of Biomedical Sciences, Chinese University of Hong Kong)

  • Bochuan Li

    (Collaborative Innovation Center of Tianjin for Medical Epigenetics, Tianjin Medical University
    Tianjin Medical University)

  • Xiao Yu Tian

    (Institute of Vascular Medicine, Shenzhen Research Institute and Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong
    School of Biomedical Sciences, Chinese University of Hong Kong)

  • Li-Jing Chen

    (Institute of Cellular and System Medicine, National Health Research Institutes)

  • Yuhong Huang

    (Institute of Vascular Medicine, Shenzhen Research Institute and Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong
    School of Biomedical Sciences, Chinese University of Hong Kong)

  • Jian Liu

    (Institute of Vascular Medicine, Shenzhen Research Institute and Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong)

  • Dan Deng

    (Institute of Vascular Medicine, Shenzhen Research Institute and Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong)

  • Chi Wai Lau

    (Institute of Vascular Medicine, Shenzhen Research Institute and Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong)

  • Song Wan

    (Chinese University of Hong Kong)

  • Ding Ai

    (Collaborative Innovation Center of Tianjin for Medical Epigenetics, Tianjin Medical University
    Tianjin Medical University)

  • King-Lun Kingston Mak

    (School of Biomedical Sciences, Chinese University of Hong Kong)

  • Ka Kui Tong

    (School of Life Sciences, Chinese University of Hong Kong)

  • Kin Ming Kwan

    (School of Life Sciences, Chinese University of Hong Kong)

  • Nanping Wang

    (Advanced Institute for Medical Sciences, Dalian Medical University)

  • Jeng-Jiann Chiu

    (Institute of Cellular and System Medicine, National Health Research Institutes)

  • Yi Zhu

    (Collaborative Innovation Center of Tianjin for Medical Epigenetics, Tianjin Medical University
    Tianjin Medical University)

  • Yu Huang

    (Institute of Vascular Medicine, Shenzhen Research Institute and Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong
    School of Biomedical Sciences, Chinese University of Hong Kong)

Abstract

YAP and TAZ, effectors of the Hippo pathway, sense mechanical forces generated by blood flow and play a role in atherosclerosis pathogenesis.

Suggested Citation

  • Li Wang & Jiang-Yun Luo & Bochuan Li & Xiao Yu Tian & Li-Jing Chen & Yuhong Huang & Jian Liu & Dan Deng & Chi Wai Lau & Song Wan & Ding Ai & King-Lun Kingston Mak & Ka Kui Tong & Kin Ming Kwan & Nanpi, 2016. "Integrin-YAP/TAZ-JNK cascade mediates atheroprotective effect of unidirectional shear flow," Nature, Nature, vol. 540(7634), pages 579-582, December.
    • Handle: RePEc:nat:nature:v:540:y:2016:i:7634:d:10.1038_nature20602
    DOI: 10.1038/nature20602
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    Citations

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    Cited by:

    1. Robin Caire & Estelle Audoux & Mireille Thomas & Elisa Dalix & Aurélien Peyron & Killian Rodriguez & Nicola Pordone & Johann Guillemot & Yann Dickerscheit & Hubert Marotte & François Vandenesch & Fréd, 2022. "YAP promotes cell-autonomous immune responses to tackle intracellular Staphylococcus aureus in vitro," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    2. Aurore Claude-Taupin & Pierre Isnard & Alessia Bagattin & Nicolas Kuperwasser & Federica Roccio & Biagina Ruscica & Nicolas Goudin & Meriem Garfa-Traoré & Alice Regnier & Lisa Turinsky & Martine Burti, 2023. "The AMPK-Sirtuin 1-YAP axis is regulated by fluid flow intensity and controls autophagy flux in kidney epithelial cells," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    3. Jiayu Liu & Chuanrong Zhao & Xue Xiao & Aohan Li & Yueqi Liu & Jianan Zhao & Linwei Fan & Zhenhui Liang & Wei Pang & Weijuan Yao & Wei Li & Jing Zhou, 2023. "Endothelial discoidin domain receptor 1 senses flow to modulate YAP activation," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    4. Yi Lei & Qiangyun Liu & Binggui Chen & Fangfang Wu & Yiming Li & Xue Dong & Nina Ma & Ziru Wu & Yanfang Zhu & Lu Wang & Yuxin Fu & Yuming Liu & Yinting Song & Mei Du & Heng Zhang & Jidong Zhu & Timoth, 2024. "Protein O-GlcNAcylation coupled to Hippo signaling drives vascular dysfunction in diabetic retinopathy," Nature Communications, Nature, vol. 15(1), pages 1-23, December.
    5. Rui Li & Jingchen Shao & Young-June Jin & Haruya Kawase & Yu Ting Ong & Kerstin Troidl & Qi Quan & Lei Wang & Remy Bonnavion & Astrid Wietelmann & Francoise Helmbacher & Michael Potente & Johannes Gra, 2023. "Endothelial FAT1 inhibits angiogenesis by controlling YAP/TAZ protein degradation via E3 ligase MIB2," Nature Communications, Nature, vol. 14(1), pages 1-17, December.

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