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NLRC3 is an inhibitory sensor of PI3K–mTOR pathways in cancer

Author

Listed:
  • Rajendra Karki

    (St. Jude Children’s Research Hospital)

  • Si Ming Man

    (St. Jude Children’s Research Hospital)

  • R. K. Subbarao Malireddi

    (St. Jude Children’s Research Hospital)

  • Sannula Kesavardhana

    (St. Jude Children’s Research Hospital)

  • Qifan Zhu

    (St. Jude Children’s Research Hospital
    Integrated Biomedical Sciences Program, University of Tennessee Health Science Center)

  • Amanda R. Burton

    (St. Jude Children’s Research Hospital)

  • Bhesh Raj Sharma

    (St. Jude Children’s Research Hospital)

  • Xiaopeng Qi

    (St. Jude Children’s Research Hospital)

  • Stephane Pelletier

    (St. Jude Children’s Research Hospital
    Embryonic Stem Cell Laboratory, St. Jude Children’s Research Hospital)

  • Peter Vogel

    (Animal Resources Center and the Veterinary Pathology Core, St. Jude Children’s Research Hospital)

  • Philip Rosenstiel

    (Institute of Clinical Molecular Biology, Christian-Albrechts-University Kiel)

  • Thirumala-Devi Kanneganti

    (St. Jude Children’s Research Hospital)

Abstract

Mice deficient in the protein NLRC3 are highly prone to colitis and tumour development in the colon as NLRC3 suppresses the activation of mTOR signalling pathways that help drive tumorigenesis.

Suggested Citation

  • Rajendra Karki & Si Ming Man & R. K. Subbarao Malireddi & Sannula Kesavardhana & Qifan Zhu & Amanda R. Burton & Bhesh Raj Sharma & Xiaopeng Qi & Stephane Pelletier & Peter Vogel & Philip Rosenstiel & , 2016. "NLRC3 is an inhibitory sensor of PI3K–mTOR pathways in cancer," Nature, Nature, vol. 540(7634), pages 583-587, December.
    • Handle: RePEc:nat:nature:v:540:y:2016:i:7634:d:10.1038_nature20597
    DOI: 10.1038/nature20597
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    Cited by:

    1. Joo-Hui Han & Rajendra Karki & R. K. Subbarao Malireddi & Raghvendra Mall & Roman Sarkar & Bhesh Raj Sharma & Jonathon Klein & Harmut Berns & Harshan Pisharath & Shondra M. Pruett-Miller & Sung-Jin Ba, 2024. "NINJ1 mediates inflammatory cell death, PANoptosis, and lethality during infection conditions and heat stress," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    2. Laurence D. W. Luu & Abhimanu Pandey & Sudarshan Paramsothy & Chinh Ngo & Natalia Castaño-Rodríguez & Cheng Liu & Michael A. Kamm & Thomas J. Borody & Si Ming Man & Nadeem O. Kaakoush, 2024. "Profiling the colonic mucosal response to fecal microbiota transplantation identifies a role for GBP5 in colitis in humans and mice," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    3. Shuyang Cai & Honghu Li & Ruxiu Tie & Wei Shan & Qian Luo & Shufen Wang & Cong Feng & Huiqiao Chen & Meng Zhang & Yulin Xu & Xia Li & Ming Chen & Jiahui Lu & Pengxu Qian & He Huang, 2024. "Nlrc3 signaling is indispensable for hematopoietic stem cell emergence via Notch signaling in vertebrates," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

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