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Profiling the colonic mucosal response to fecal microbiota transplantation identifies a role for GBP5 in colitis in humans and mice

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  • Laurence D. W. Luu

    (UNSW
    UNSW)

  • Abhimanu Pandey

    (The Australian National University)

  • Sudarshan Paramsothy

    (The University of Sydney
    Concord Repatriation General Hospital)

  • Chinh Ngo

    (The Australian National University)

  • Natalia Castaño-Rodríguez

    (UNSW)

  • Cheng Liu

    (QIMR Berghofer Medical Research Institute
    University of Queensland
    Mater Hospital Brisbane)

  • Michael A. Kamm

    (St Vincent’s Hospital
    University of Melbourne)

  • Thomas J. Borody

    (Centre for Digestive Diseases)

  • Si Ming Man

    (The Australian National University)

  • Nadeem O. Kaakoush

    (UNSW)

Abstract

Host molecular responses to fecal microbiota transplantation (FMT) in ulcerative colitis are not well understood. Here, we profile the human colonic mucosal transcriptome prior to and following FMT or placebo to identify molecules regulated during disease remission. FMT alters the transcriptome above the effect of placebo (n = 75 vs 3 genes, q

Suggested Citation

  • Laurence D. W. Luu & Abhimanu Pandey & Sudarshan Paramsothy & Chinh Ngo & Natalia Castaño-Rodríguez & Cheng Liu & Michael A. Kamm & Thomas J. Borody & Si Ming Man & Nadeem O. Kaakoush, 2024. "Profiling the colonic mucosal response to fecal microbiota transplantation identifies a role for GBP5 in colitis in humans and mice," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-46983-5
    DOI: 10.1038/s41467-024-46983-5
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    References listed on IDEAS

    as
    1. Eric R. Littmann & Jung-Jin Lee & Joshua E. Denny & Zahidul Alam & Jeffrey R. Maslanka & Isma Zarin & Rina Matsuda & Rebecca A. Carter & Bože Susac & Miriam S. Saffern & Bryton Fett & Lisa M. Mattei &, 2021. "Host immunity modulates the efficacy of microbiota transplantation for treatment of Clostridioides difficile infection," Nature Communications, Nature, vol. 12(1), pages 1-15, December.
    2. Rajendra Karki & Si Ming Man & R. K. Subbarao Malireddi & Sannula Kesavardhana & Qifan Zhu & Amanda R. Burton & Bhesh Raj Sharma & Xiaopeng Qi & Stephane Pelletier & Peter Vogel & Philip Rosenstiel & , 2016. "NLRC3 is an inhibitory sensor of PI3K–mTOR pathways in cancer," Nature, Nature, vol. 540(7634), pages 583-587, December.
    3. Shouya Feng & Daniel Enosi Tuipulotu & Abhimanu Pandey & Weidong Jing & Cheng Shen & Chinh Ngo & Melkamu B. Tessema & Fei-Ju Li & Daniel Fox & Anukriti Mathur & Anyang Zhao & Runli Wang & Klaus Pfeffe, 2022. "Pathogen-selective killing by guanylate-binding proteins as a molecular mechanism leading to inflammasome signaling," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    4. Alyse L. Frisbee & Mahmoud M. Saleh & Mary K. Young & Jhansi L. Leslie & Morgan E. Simpson & Mayuresh M. Abhyankar & Carrie A. Cowardin & Jennie Z. Ma & Patcharin Pramoonjago & Stephen D. Turner & Ali, 2019. "IL-33 drives group 2 innate lymphoid cell-mediated protection during Clostridium difficile infection," Nature Communications, Nature, vol. 10(1), pages 1-13, December.
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